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EC number: 601-601-6 | CAS number: 119345-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 48-hour EC50 for Daphnia magna was 1.64 mg/L Dowfax 2A1 (based on active ingredient).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.64 mg/L
Additional information
Three acute toxicity tests with invertebrates were assessed for this endpoint. Two acute toxicity tests with Dowfax 2A1 were conducted with Daphnia magna, and one acute toxicity test was conducted with Ceriodaphnia dubia. Only one of the studies conducted with Daphnia magna were considered reliable. The Dow Chemical Company study conducted with Daphnia magna in 1978 contained very little experimental detail, and therefore the reliability of the study could not be ascertained (Klimish score = 4). The other acute toxicity test with Daphnia magna conducted by the Dow Chemical Company in 1988 was rated as reliable (Klimish score = 2). In this study, the 48-hour LC50 value for D. magna was reported as 1.64 mg/L (based on active ingredient of Dowfax 2EP, a.k.a Dowfax 2A1). Additionally, an acute toxicity endpoint for Dowfax 2EP (a.k.a. Dowfax 2A1) was included in a 7-day chronic study with Ceriodaphnia dubia conducted by The Dow Chemical Company in 1990. This study was deemed reliable (Klimish score = 2), and the 48 hour LC50 for C. dubia was reported as 5.3 mg/L Dowfax 2EP (a.k.a. Dowfax 2A1). Since these toxicity tests were conducted with two different invertebrate species, the lower of the two values (1.64 mg/L based on active ingredient) was selected as the key parameter for this endpoint.
An additional, supporting study was included for this endpoint. In this study effluent spiked with Dowfax 2A1 elicited toxicity to Daphnia magna, whereas non-spiked effluent (negative control) and effluent containing biodegradation products from activated sludge treatment of Dowfax 2A1 did not elicit toxicity to daphnia.
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