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EC number: 209-813-7 | CAS number: 593-85-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No short-term toxicity in the classifiable range of CLP
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 41 mg/L
Additional information
The short-term toxicity of Guanidine carbonate (CAS 593-85-1) to aquatic invertebrates was investigated in a GLP-compliant study (Fenzl 1998) using daphnids (Daphnia magna) according to the EU C.1 (1992) protocol. The experiment is deemed valid, conclusive and thus suitable for assessment without restrictions.
Twenty daphnids (4 replicates of 5 animals) were exposed to nominal test item concentrations of 0, 10, 18, 32, 56 and 100 mg/L. Mean measured concentrations (two replicates) were determined at the two highest concentrations and analytically 96 to 104 % of nominal were verified. Thus the effects were related to the nominal concentrations. Immobilisation and animals trapped at the surface were recorded after 24 and 48 h.
Effects were observed from 32 mg/L on. After 48-h 25 % of the test animals were recorded immobile at this level, 80 % at 56 mg/L and 100 % (all 20 daphnids) at 100 mg/L. Accordingly the acute toxicity of the test item to the freshwater invertebrates gave a 48-h EC 50 of 41 mg/L with 95 % confidence limits of 35 and 48 mg/L. No animals were trapped at the surface.
In conclusion the test item was found not toxic to aquatic invertebrates up to the relevant levels considered for acute hazard to the aquatic life in the EU (i.e. 10 mg/L according to CLP, Regulation (EC) No 1272/2008) and no aquatic hazard classification is required the results of this study.
The study of van der Schalie (1985), used to read-across the long-term effects revealed a 48-h EC50 of the source chemical 70.2 mg Guanidine mononitrate/L, which delivers on the basis of equimolar conversion to the target chemical in 51.8 mg Guanidine carbonate/L. This supports the applicability of the employed approach.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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