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EC number: 209-813-7 | CAS number: 593-85-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No long-term toxicity in the classifiable range of CLP
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.14 mg/L
Additional information
The long-term toxicity of Guanidine mononitrate (CAS 506-93-4) to aquatic invertebrates was investigated in a study (van der Schalie 1985) using reproduction of daphnids (Daphnia magna) comparable to the OPPTS 850.1300 (1996) and OECD TG 211 (1998) protocols. GLP is not stated. The experiment is deemed valid, conclusive and thus suitable for assessment with restrictions.
The test animals were exposed during 21 days under flow through conditions to control and test item concentrations of nominal 60, 33.6, 18.8, 10.5, and 5.9 mg/L (measured 52, 26.2, 16.8, 8.8, 4.2 mg/L) in the first test and 6.19, 3.45, 1.97, 1.08, 0.63 mg/L (measured 6.09, 2.90, 1.66, 1.14, 0.75 mg/L) in the second test respectively. In the first test significant toxic effects were found at all treatments. Therefore a second, definitive test was performed with lower concentrations. The effects were related to the measured concentrations. In test system (Test 2) was maintained at 19.4-20.6 °C, 7.6 to 8.7 mg/L mg dissolved oxygen/L and a pH of 7.8 to 8.2. The hardness of the test media were 165 to181 mg/L CaCO3, which corresponds to more than ca. 99-109 mg carbonate/L. The effect parameters measured were survival, total young per replicate tank, growth reproduction rate, immobilization and the number young per female per replicate day, which was the most sensitive endpoint, different from control at the highest tested level.
Accordingly the 21-d NOEC and LOEC-values, based on reproduction were 2.9 and 6.09 mg test item/L respectively. The NOEC corresponds to 23.7 µmol Guanidinium kation/L or considering equimolar conversion to this species 2.14 mg Guanidine carbonate (CAS 593-85-1)/L.
In conclusion the test item (source chemical) was found not being toxic to aquatic invertebrates up to the relevant levels considered for long-term hazard to the aquatic life in the EU (i.e. 1 mg/L according to CLP, Regulation (EC) No 1272/2008)) and no aquatic hazard classification is required the results of this study. This conclusion can be read-across to the target chemical Guanidine carbonate.
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