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Diss Factsheets
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EC number: 209-813-7 | CAS number: 593-85-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 25
- Absorption rate - inhalation (%):
- 100
Additional information
No ADME and dermal absorption studies with guanidine carbonate are available.
However, a series of acute toxicity studies give an indication about the bioavailability after oral and dermal application. In three acute and one repeated dose oral toxicity studies with guanidine carbonate systemic toxicity was seen leading to the conclusion that the test substance is bioavailable after oral application.
After dermal application of 2000 mg test substance/kg bw in a rat acute toxicity study and dermal application in two guinea pig sensitization studies no systemic effects could be observed. The octanol/water partition coefficient of -1.63 (20 °C) indicates the highly hydrophilic property of the substance. Therefore, it is assumed that the dermal absorption of guanidine carbonate is rather low.
Vaporisation is deemed negligible as the vapour pressure will be clearly <10^-10 Pa as guanidine carbonate is a solid ionic crystal. Therefore, inhalation exposure is only possible via aerosols of solid particles or dissolved material.
In the body the salt guanidine carbonate is dissociated to guanidine. Guanidino compounds, including guanidine are considered to be metabolic products of protein catabolism. In the body guanidine is well distributed with the plasma and after injected in the mice intraperitoneally linear increase in brain concentration is found (D`Hooge et al., 1992) indicating that there is no blood brain barrier. Due to the high water solubility and the low partition coefficient accumulation in fatty tissues is unlikely. Guanidine is not further metabolized and excreted unchanged via renal clearance (Sawynok et al., 1972).
Following absorption values were taken into account:
- Inhalation: 100 % (worst case assumption)
- Oral: 50% (this can be considered as a conservative value, based on the comparison between the LD50subcutaneous versus oral in rats for Guanidine, which is at least 3 times lower); currently in the dossier 50% absorption after oral application was described.
- Dermal: 25% (this can be considered as a conservative value, based on the comparison between the LD50oral versus dermal in rats for Guanidine carbonate and Guanidine chloride, which is at least 2 times lower).
References:
D’Hooge R., Pei Y.-Q., Marescau B., De Deyn P.P. (1992); Convulsive action and toxicity of uremic guanidino compounds: behavioral assessment and relation to brain concentration in adult mice. Journal ofNeurological Sciences, 112, 92-105.
Sawynok J., Dawborn J.K. (1972); Plasma concentration and urinary excretion of guanidine derivates in normal subjects and patients with renal failure. Clinical and Experimental Pharmacology and Physiology, 2, 1-15.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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