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Diss Factsheets
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EC number: 466-490-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experiment start date - 01 August 2006; Experiment completion date - 11 August 2006; Study completion date - 30 September 2006.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Identity: FAT 40827/A
Batch: T2 5572 BOP 01/06
Purity: determined in this study
Appearance: black sticky powder
Expiration date: 28.02.2011
Storage: at room temperature - Analytical monitoring:
- yes
- Details on sampling:
- - Just before the start of the test:
Duplicate samples from the test medium (without daphnids)
Duplicate samples from the control (without daphnids)
- After 48 hours (stability samples):
Duplicate samples from the test medium
Duplicate samples from the control
The 48-hour stability samples were taken from the actual test. For sampling, the contents of the respective replicates were combined prior to sampling. All samples were deep-frozen (at about -20 °C) immediately after sampling. - Vehicle:
- no
- Details on test solutions:
- The test medium was prepared by dissolving 29.8 mg of test item completely in 300 mL of test water using intense stirring for 15 minutes at room temperature. The test medium was prepared just before introduction of the daphnids (i.e.: start of the test).
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name:
- Strain: Daphnia magna
- Source: University of Sheffield/UK
- Age at study initiation: 6-24 hours old - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 2.5 mmol/L (= 250 mg/L as CaCO3)
- Test temperature:
- 20-22 °C
- pH:
- 7.8 - 7.9
- Dissolved oxygen:
- 8.7 - 8.8
- Nominal and measured concentrations:
- Nominal: 100 mg/L
Measured: 107 mg/L (start), 104 mg/L (end) - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL glass beaker
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: 50 mL
- Aeration: No
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 1
- Biomass loading rate: 10mL/daphnia
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Reconstituted test water
- Alkalinity: 0.8 mmol/L
- Ca/mg ratio: 4 : 1 (based on molarity)
OTHER TEST CONDITIONS
- Photoperiod: 16-hour light to 8-hour dark photoperiod (with a 30 minute transition period)
- Light intensity: Approximately 470 and 640 Lux
TEST CONCENTRATIONS
- Range finding study
- Test concentrations: No data
- Results used to determine the conditions for the definitive study: 100 mg/L - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- No remarkable observations were made concerning the appearance of the test medium.
- Results with reference substance (positive control):
- 48-hour EC50: 0.67 mg/L
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance did not show any mortality towards Daphnia magna up to 100 mg/L. Thus, the substance is considered to be of low toxicity to daphnids.
- Executive summary:
The acute toxicity of the test item FAT 40827/A to Daphnia magna was determined in a 48-hour static test according to the EU Commission Directive 92/69/EEC, Part C.2 (1992) and the OECD Guideline for Testing of Chemicals, No. 202 (2004). A limit test was performed in accordance with the test guidelines to demonstrate that the test item has no toxic effect on the test organisms up to and including the concentration of 100 mg/L. Thus, the only nominal concentration tested was 100 mg/L and a control. The analytically determined concentration of the test item in the test medium at the start and the end of the test was 107 and 104 % of the nominal value, respectively. Thus, the test item was stable during the test period of 48 hours under the test conditions. The reported biological results were based on the nominal concentration of the test item. In the control and at the test item concentration of 100 mg/L, no immobilized test organisms were observed during the test period of 48 hours. Therefore, the 48-hour NOEC (highest concentration tested without toxic effects after the exposure period of 48 hours) and the 48-hour ECO of FAT 40827/A to Daphnia magna were determined to be at least 100 mg/L. These values might even be higher but concentrations above 100 mg/L were not tested, in accordance with the test guidelines. The 48-hour EC50 and the 48-hour EC100 were clearly higher than 100 mg/L. These values could not be quantified due to the absence of toxicity of FAT 40827/A at the test concentration of 100 mg/L.
Reference
Description of key information
The 48-hour EC50 and the 48-hour EC100 were higher than 100 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
The acute toxicity of the test item FAT 40827/A to Daphnia magna was determined in a 48-hour static test according to the EU Commission Directive 92/69/EEC, Part C.2 (1992) and the OECD Guideline for Testing of Chemicals, No. 202 (2004). A limit test was performed in accordance with the test guidelines to demonstrate that the test item has no toxic effect on the test organisms up to and including the concentration of 100 mg/L. Thus, the only nominal concentration tested was 100 mg/L and a control. The analytically determined concentration of the test item in the test medium at the start and the end of the test was 107 and 104 % of the nominal value, respectively. Thus, the test item was stable during the test period of 48 hours under the test conditions. The reported biological results were based on the nominal concentration of the test item. In the control and at the test item concentration of 100 mg/L, no immobilized test organisms were observed during the test period of 48 hours. Therefore, the 48-hour NOEC (highest concentration tested without toxic effects after the exposure period of 48 hours) and the 48-hour ECO of FAT 40827/A to Daphnia magna were determined to be at least 100 mg/L. These values might even be higher but concentrations above 100 mg/L were not tested, in accordance with the test guidelines. The 48-hour EC50 and the 48-hour EC100 were clearly higher than 100 mg/L. These values could not be quantified due to the absence of toxicity of FAT 40827/A at the test concentration of 100 mg/L.
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