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Diss Factsheets
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EC number: 614-587-1 | CAS number: 68551-92-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Oral:
- acute toxicity, oral, rat, Wistar, OECD 423, discriminating dose-value (female/male) 2000 mg/kg bw (no treatment related effects) (BASFSE, 2012, 10A0072/12X137)
Dermal:
- acute toxicity, dermal, rat, Wistar, OECD 402, dermal discriminating dose-value (female/male) 5000mg/kg bw (no treatment related effects) (BASFSE, 2012, 11A0072/12X138)
Inhalation:
- No information on acute inhalation available for Fatty acids, C18-unsatd., dimers, ethoxylated
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- GLP and guideline compliant study.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- GLP and guideline compliant study.
Additional information
There are valid study data available assessing the acute oral and dermal toxicity of Fatty acids, C18-unsatd., dimers, ethoxylated. No valid information for Fatty acids, C18-unsatd., dimers, ethoxylated on inhalation toxicity is available.
Oral:
OECD conform studies:
In an acute oral toxicity study according to OECD TG 423, the test substance was administered by oral gavage to two groups of three female Wistar rats 2000 mg/kg bw(BASFSE, 2012, 10A0072/12X137). The test substance was administered undiluted at 2 mL/kg bw. All animals were weighed prior to dosing and at termination. They were observed frequently on the day of dosing and daily for a total of 14 days. All gross and visible toxic or pharmacological effects were recorded. No animals died on account of the treatment nor did they show severe signs of toxicity. The oral discriminating dose value of the test substance in female Wistar rats was estimated to be 2000 mg/kg bw.
Dermal:
OECD conform studies:
In an acute dermal toxicity study according to OECD TG 402, the test substance was administered (single 24-hour dermal application) to five Wistar rats of each sex at 5000 mg/kg bw(BASFSE, 2012, 11A0072/12X138). All animals were weighed prior to dosing and at termination. They were observed frequently on the day of dosing and daily for a total of 14 days. None of these animals died. Clinical signs or dermal symptoms were not observed during the 14 days post-treatment observation period. No effects on mean body weight and body weight gain were noted. Specific macroscopic alterations related to the toxic effect of the test substance were not found. The dermal discriminating dose value of the test substance in Wistar rats was estimated to be 5000 mg/kg bw.
Assessment of acute toxicity:
Oral: The only available animal study points to high acute oral toxicity. The discriminating dose determined is 2000 mg/kg without any substance related effect. Therefore a very low acute oral toxicity is assumed and no classification is derived.
Dermal: The information available for the available acute dermal toxicity study points to very low dermal toxicity. The discriminating dose (without any substance related effect) determined is 5000 mg/kg. Therefore a very low acute dermal toxicity is assumed and no classification is derived.
Inhalation: No acute inhalation study available is available. This study was not proposed or conducted because exposure consideration point to a more likely dermal and oral exposure and according to the REACH Regulation (EC) No 1907/2006, Annex VIII, 8.5 only information on two application routes needs to be provided, with test item administration via the most appropriate route.
Key study assignment:
As there is only one relevant and reliable study available assessing each the oral and the dermal toxicity and both were well performed and documented according to OECD guidelines and under GLP, these study were therefore included as key studies.
No acute inhalation study available
Justification for selection of acute toxicity – oral endpoint
GLP and guideline compliant study.
Justification for selection of acute toxicity – dermal endpoint
GLP and guideline compliant study.
Justification for classification or non-classification
Based on the available results above,no classification and labelling is required according to Regulation No (EC) 1272/2008 (CLP) or Directive 67/548/EEC (DSD) criteria.
Labelling for acute toxicity:
GHS: no classification
DSD: no classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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