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EC number: 825-403-6 | CAS number: 2060541-51-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24-26 November 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Good quality study under GLP, however no chemical analyses and no certificate of analysis. Description of the test substance is limit but consider sufficient.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- No Chemical analysis
- Principles of method if other than guideline:
- no chemical analyses
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Details on sampling:
- no chemical analyses
- Details on test solutions:
- Direct dispersion in water. 200 mg of test material was dissolved in aged and dechlorinated tap water and the volume adjusted to 2 litres to give a 100 mg/L stock solution from which dilutions were made to give the test series.
tested concentrations: 1.0, 1.8, 3.2, 5.6, 10, 18, .32, 56 and 100 mg/L test substance - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Laboratory culture originating from a strain supplied by the Institut National de Recherche Chimique Appliquée (I.R.CH.A), France Gravid adults were isolated 24 hours prior to intiation of the test. Young daphnids produced overnight were used for testing.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- no
- Hardness:
- Approximately 50 mg/L as CaCO3
- Test temperature:
- 20-21 ºC
- pH:
- 7.7-7.8
- Dissolved oxygen:
- 7.9-8.4 mgO2/L
- Nominal and measured concentrations:
- nominal concentrations: 1.0, 1.8, 3.2, 5.6, 10, 18, .32, 56 and 100 mg/L test substance
- Details on test conditions:
- The test material was suspected to adsorb to glassware and so saturation of the adsorption sites was achieved by soaking the test vessels overnight pr.ior to the start of the test with the test solutions. At 0 hours the test vessels were emptied, rinsed with the solution to be tested and then refilled with the fresh. solution.
Test vessels were Glass jars each containing 200 mL test solution and covered to reduce evaporation. 9 test concentrations plus 1 control each in duplicate were tested with 20 animals per concentration. - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 14 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL (12-16 mg/L)
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 35 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95%CL (31-39 mg/L)
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 18 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- no reference substance
- Reported statistics and error estimates:
- 48 h EC50= 35 mg/L 95%CL (31-39 mg/L) test substance
- Validity criteria fulfilled:
- yes
- Conclusions:
- Good quality study, however no chemical analyses therefore concentrations nominal. furtheremore the is no certifcate of analysis and description of test substance is limited but considered sufficient.
- Executive summary:
STUDY SPONSOR: Berol Nobel AB
PROJECT NUMBER: 116/128
TEST MATERIAL: Ampholak 7CX
TEST SPECIES: Daphnia mama Straus tested in the 1st instar.
TEST TYPE: Acute toxicity. 48h EC50 (immobilisation)
TEST CONDITIONS: Static test conditions according to OECD Guideline No. 202,. referenced as Method C.2 of Commission Directive 84/449/EEC (which constitutes Annex V of.Council Directive 67/548/EEC).
RESULTS
These results are based on nominal test concentrations:
24h EC50= 55 mg/L 95% CL 48 - 63 mg/L
48h EC50= 35 mg/L 95% CL 31 - 39 mg/L
"No Observed Effect Concentration" (NOEC) at 24 h = 18 mg/l (7.2 mg a i / l )
"No Observed Effect Concentratio'n" (NOEC) at 48 h = 18 mg/l (7.2 mg a i / l )
ai = active ingredient
Reference
Concentration (mg/L) |
Cumulative immobilized Daphnia (initial population : 10 per concentration) |
|||||||
24 hours |
48 hours |
|||||||
R1 |
R2 |
Total |
% |
R1 |
R2 |
Total |
% |
|
Control |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1.0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1.8 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3.2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
5.6 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
10 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
18 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
32 |
1 |
0 |
1 |
5 |
4 |
3 |
7 |
35 |
56 |
5 |
5 |
10 |
50 |
10 |
10 |
20 |
100 |
100 |
10 |
10 |
20 |
100 |
10 |
10 |
20 |
100 |
Description of key information
One acute daphnia study with Sodium cocoamphopolycarboxy glycinate is available from Sewell & Wetton (1992). The study lacks like other studies from this period, the quantification of the test substance during the test. When this study was performed no suitable sensitive analytical method was available for the quantification of this test substance. The study from Sewell & Wetton resulted in a 48h EC50 for daphnia of 14 mg a.i./L based on nominal test concentrations.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 14 mg/L
Additional information
One acute daphnia study with Sodium cocoamphopolycarboxy glycinate is available from Sewell & Wetton (1992). The study lacks like other studies from this period, the quantification of the test substance during the test.
When this study was performed no suitable sensitive analytical method was available for the quantification of this type of test substances. The substance is however very soluble (575 g/L) and is therefore expected to be completely bioavailable during the acute fish and daphnia ecotoxicity tests. During algae tests however a decrease of the dissolved test substance concentration is anticipated due to some sorption of the substance to the large surface area of the algae. Where for the acute fish and daphnia the use of nominal concentrations is considered appropriate a geometric mean should if possible be applied to the algae test results.
The study from Sewell & Wetton resulted in a 48h EC50 for daphnia of 14 mg a.i./L based on nominal test concentrations.
The algae study from Sodium oleylamphopolycarboxy glycinate is read across to Sodium cocoamphopolycarboxy glycinate and for bridging reasons the acute daphnia study with sodium oleylamphopoly carboxy glycinate added to this dossier.
The study from Handley and Wetton (1992) with Sodium oleylamphopolycarboxy glycinate resulted in a 48h EC50 for daphnia magna of 2.4 mg a.i./L based on nominal test concentrations indicating a higher toxicity of the oleyl version of this substance when compared to the coco version.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.