Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 273-729-7 | CAS number: 69012-29-9 By-product from the production of ferronickel from a complex ore. Consists primarily of oxides of aluminum, iron, magnesium and silicon.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
There is some (inconclusive) evidence for bioaccumulation of slags’ components which may affect long-term toxicity of the substance.
Generally, experimental field studies in local environment indicate that the local environment is enriched with a variety of metals and these metals are accumulated by marine organisms. However, different species accumulate different metals to a different extent and assessments of the effects of pollution must be taken into account. A series of oceanographic studies available to the Lead Registrant has not found any evidence that chronic exposure of marine organisms to slags can be harmful to them but only large quantities of the material can cause disruption of the benthic ecosystem, as would happen with practically any element discarded in great volumes (ELKETHE, 2009).
Long-term toxicity studies for fish on slags, ferronickel-manufg. show that there is no toxicity up to the measured concentration (Gonsior, 2011a). To further augment these findings and produce an as much as possible representative PNEC, a read-across approach was chosen to be followed, based on the individual constituents of the substance.
Nickel was found to be the most important critical constituent. Studies on its chronic toxicity to fish showed that this substance produces toxic effects on fish at concentrations much higher than its maximum water solubility from ferronickel slags that is usually observed in solubility or leachability tests. Calcium and Sulfur are the two most soluble elements in ferronickel slags, but their acute toxicity to fish is insignificant. Magnesium and iron are both of low solubility and ecotoxicological activity, therefore they will not affect the resolution.
Key value for chemical safety assessment
Additional information
Slags, ferronickel manufg. has no toxicity and it does not need to be classified as toxic to the aquaticenvironmentbased on available long-term studies on the aquatic toxicity of the slags (performed for potential disposal as waste) which showed no mortality or toxicity up to the measured concentration for fish (Gonsior, 2011). These results show that no classification for aquatic hazards is required for the slags, according to CLP.
There issome(inconclusive) evidence for bioaccumulation of slags’ components which may affect long-term toxicity of the substance. Generally, experimental field studies in local environment indicate that the local environment is enriched with a variety of metals and these metals are accumulated by marine organisms. However, different species accumulate different metals to a different extent and assessments of the effects of pollution must be taken into account.A series of oceanographic studies available to the Lead Registrant has not found any evidence that chronic exposure of marine organisms to slags can be harmful to thembut only large quantities of the material can cause disruption of the benthic ecosystem, as would happen with practically any element discarded in great volumes(ELKETHE, 2009).
The CLP Regulation puts priority on information that is available for the whole substance. Slags, ferronickel manufg. is not considered a mixture and the following approach based on mixture rules is not recommendable. Nickel is the only constituent of the substance that is considered toxic to the aquatic environment (Aquatic Chronic 3 in powder form) but its content in the slags is not high enough to characterise them as toxic as well, according to the mixture rules described in the CLP.
To further augment these findings and produce an as much as possible representative PNEC, a read-across approach was chosen to be followed, to assess the toxicity of the individual constituents of the substance. Several long-term tests with soluble Nickel compounds produced EC10/20 and LOEC/NOEC values that are higher than the maximum solubility of Nickel that is observed in water solubility or leachability tests of ferronickel slags, so no adverse effects are expected because of it.
Iron Oxides
Iron has no known toxic effects to the aquatic environment.Available data do suggest that iron salts are relatively non toxic and this was sufficient for the EU Classification and Labeling Committee to determine that there was no need for classification of iron salts. It was also concluded that iron massive and sparingly soluble forms of iron are highly insoluble and non-hazardous. The solubility of iron species of the slag is insignificant.
Calcium Oxide
CaO effect is mainly its contribution to water pH after its transformation to Ca(OH)2. However, in large dilutions (e.g. in sea or in rivers where constant current exists) this has insignificant effect. Furthermore, Calcium Oxide is bound in the mineral matrix of the slags which reduces significantly its reactivity.This has been verified in the acute oral and inhalation toxicity experiments of CS (see 4.2.1.1 and 4.2.1.2 respectively) as well as in the skin and eye irritation experiments (see 7.3.1 and 7.3.2 respectively). It is concluded that CaO is of negligible toxicity in ferronickel slags.
Chromium (III)
No studies of chronic toxicity of Cr(III) to fish were found. However, this is expected due to the low toxic and genotoxic potential of Cr(III) species. A study on the speciation of Chromium in Ferronickel slags using alkaline digestion and colorimetric analysis (EPA 3060A and EPA 7196A respectively) showed that no hexavalent Chromium species were present up to the limit of detection of the analytical method (20mg/kg) so all Cr in the substance is considered to be in trivalent form.Toxicity to aquatic organisms due to Cr(III) leaching from slags ferronickel manufg is therefore not expected.
Nickel
Nickel was found out to be the constituent with the highest potential for aquatic toxicity. From the species examined, it was also observed that marine species showed higher tolerance to Ni than freshwater species.
Brix et al. (2004) studied the chronic toxicity of Ni to rainbow trout (Oncorhynchus mykiss). Test solutions were prepared by diluting a stock solution of Nickel chloride. The authors found a substantially higher Ni chronic effects threshold for rainbow trout than reported in previous study and a NOEC of 0.466mg Ni/L.
Birge et al. (1984) studied the long term of soluble Ni compounds to embryo and sac fry stages of P.promelas in a flow-through setup for 32 days. A NOEC of 0.057mg Ni/L was derived, based on mortality, terata and length. A LOEC of 0.12mg Ni/L was based on mortality and terata.
Nebeker et al. (1985) derived a NOEC of 35μg Ni/L, based on survival and growth on freshwater fish O.mykiss after a flow-through test on early fish stages, after exposure to dissolved Nickel Chloride.
Dave and Xiu (1991) studied the freshwater fish D.rerio for 8 -day exposure to dissolved Nickel Chloride in a semi-static setup on early fish stages (embryo and sac-fry). A NOEC of 40μg Ni/L was derived, based on hatching time.
Studies on marine species showed much higher NOECs. More specifically, Hunt et al (2002) in a 40-day flow-through test on A.affinis (early life stage: reproduction) derived an EC10 of 4.2mg dissolved Ni/L based on survival. Additionally, Golder Associated Ltd (2007), derived a NOEC of 21.7mg Ni/L based on survival and growth of C.variegatus after an early life stage: reproduction flow-through test.
Rest of constituents
Of the other components, Magnesium has no known toxic effects to the aquatic environment. Aluminium is also supposed to be a benign metal, however it has been found to produce toxic effects in short-term exposure under very specific environmental conditions, due to colloidal formation. In Ferronickel Slag, its low water solubility prevents it from producing adverse effects to the aquatic environment.
From this read-across approach, Nickel was identified to be the constituent most dangerous to the aquatic environment and the only one that has a relevant classification (Aquatic Chronic 3). For that reason, the PNEC aquatic will be based on NOECs from studies on Nickel and more specifically the Nickel PNECs, that are available for use by the Lead Registrant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.