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Diss Factsheets
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EC number: 297-626-1 | CAS number: 93685-78-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Carcinogenicity
Administrative data
Description of key information
On the basis of the available evidence it can be concluded that butylene oligomers are not genotoxic and are unlikely to be carcinogenic
Key value for chemical safety assessment
Justification for classification or non-classification
There is no data to suggest that classification of butylene oligomers is warranted under DSD or CLP.
Additional information
There are no carcinogenicity studies for the butylene oligomers category members.
Butylene oligomers are simple olefins that do not carry alerts for genotoxic activity.
Butylene oligomers have been tested in a number of well recognised assays for genotoxicity and have shown no significant genotoxic activity in vitro and in vivo. In vitro assays comprise six bacterial reverse mutation assays with olefins ranging from C8 to C20/24 and two mammalian chromosome aberration tests with C8. In vivo mutagenicity assays comprise four mammalian erythrocyte micronucleus tests in the mouse or the rat covering three different routes of administration oral, inhalation and intraperitoneal and olefins ranging from C8 to C20/C24. The results are consistent throughout the category and indicate that butylene oligomers are not expected to be genotoxic carcinogens.
Repeat dose toxicity studies with higher olefins spanning the range C8 to C20 indicate that these materials are of low toxicity in rats. There is a consistent finding of male rat kidney effects indicative of alpha-2u-globulin nephropathy with the C8 to C14 higher olefins. Although α2u-Globulin has been associated with chemically induced renal toxicity and neoplasia in the male rat, the nephropathy is a syndrome that occurs exclusively in male rat kidney and is not relevant for humans.
There is no evidence of target organ toxicity or pre-neoplastic changes in repeated dose studies with butylene oligomers which suggest that they are likely to be genotoxic.
Hard GC, Rodgers IS, Baetcke KP, Richards WL, McGaughy RE, and Valcovic LR (1993)Environ Health Perspect.1993 March;99: 313–349.Hazard evaluation of chemicals that cause accumulation of alpha 2u-globulin, hyaline droplet nephropathy, and tubule neoplasia in the kidneys of male rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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