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EC number: 469-070-1 | CAS number: 17861-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The potential for skin and eye irritation/corrosion was tested in vivo according to OECD guidelines 404 and 405. No adverse effects were observed in the studies.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- 31 July 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 17 July 1992
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Density: 828 g/L at 20°C
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Test animals:
Age on arrival: 9 weeks
Acclimatisation: 5 days
Bodyweight at start of study: 1.709-2.007 kg
Housing: individually housed in stainless steel cages
Diet: standard laboratory diet ad libitum
Water: tap water ad libitum
Environmental conditions:
Temperature: 20 +/-3°C
Humidity: 30-70%
Ventilation: 10 air changes per hour
Lighting: 12 hours light/dark cycle - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.5 mL test material was distributed on a gauze patch measuring 2.5 x 2.5 cm and fixed to the clipped flank of the animal.
- Duration of treatment / exposure:
- 4 h
- Observation period:
- Skin reactions were evaluated one hour after treatment then at 24, 48 and 72 hours after treatment
- Number of animals:
- 3 males
- Details on study design:
- The patch loaded with the test material was fixed to the application site by means of semi occlusive adhesive tape.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results obtained it is concluded that heptamethylethyltrisiloxane is non-irritating to skin under conditions of this study therefore no classification is required
- Executive summary:
The primary skin irritation potential of heptamethylethyltrisiloxane was evaluated in three male New Zealand White rabbits. A dose of 0.5 mL of the test substance was placed on a gauze patch and applied to clipped intact dorsal skin of each rabbit for 4 hours. Skin reactions of erythema and oedema were scored 1, 24, 48 and 72 hours after removal of the patches. Skin irritation reactions were not observed in any animals during the observation period after the removal of patch.
Based on these results, heptamethylethyltrisiloxane is considered to be a non-irritant.
Reference
Skin irritation scores
Animal no. |
Time after removal of test material (hours) |
|||
1 |
24 |
48 |
72 |
|
A-B |
||||
8 (#1) |
0-0 |
0-0 |
0-0 |
0-0 |
10 (#2) |
0-0 |
0-0 |
0-0 |
0-0 |
12 (#3) |
0-0 |
0-0 |
0-0 |
0-0 |
A = erythema (including ischemia, haemorrhages and incrustation)
B = oedema
Mean values for erythema and oedema for each rabbit scored 24, 48 and 72 h after treatment was zero.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 November 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Version / remarks:
- 31 July 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 1987
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Density: 828 g/L at 20°C
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Test animals:
Age on arrival: 9 weeks
Acclimatisation: 5 days
Bodyweights at study start: 1.67-1.931 kg
Housing: individually housed in stainless steel cages
Diet: standard laboratory diet ad libitum
Water: tap water ad libitum
Environmental conditions:
Temperature: 20 +/- 3°C
Humidity: 30-70%
Ventilation: 10 air changes/h
Lighting: 12 h light/dark cycle - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: one eye of each animal was treated, the other eye served as a control
- Amount / concentration applied:
- 0.1mL instilled into the conjuctival sac of one eye of each rabbit. Eyes were unwashed post treatment
- Duration of treatment / exposure:
- 72 h
- Observation period (in vivo):
- The reactions of the eye were evaluated at 1,24,48 and 72 h after instillation
- Number of animals or in vitro replicates:
- 3
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritant / corrosive response data:
- Animal #1 showed conjuctival redness and chemosis, both grade 1 at the 1 h timepoint
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results obtained, it is concluded that heptamethylethyltrisiloxane is slightly irritating to the eye under the conditions of this study, and does not require classification.
- Executive summary:
The primary eye irritation potential of heptamethylethyltrisiloxane was evaluated in three male New Zealand White rabbits. A volume of 0.1 ml of the test substance was applied to one eye of each rabbit.The irritation reactions were observed 1, 24, 48 and 72 hours after application.
In 1 out of 3 rabbits redness (grade 1) and chemosis (grade 1) in the conjunctiva were observed after application. I. Chemosis disappeared 24 hours after application and redness disappeared 48 hours after dosing. .
Based on the results of the study heptamethylethyltrisiloxane is considered to be a slight irritant to the rabbit eye and does not require classification.
Reference
|
Cornea |
Iris |
Conjunctiva redness |
Conjunctiva chemosis |
||||||||
Time/animal |
26 (#1) |
28 (#2) |
30 (#3) |
26 (#1) |
28 (#2) |
30 (#3) |
26 (#1) |
28 (#2) |
30 (#3) |
26 (#1) |
28 (#2) |
30 (#3) |
1 h |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
1 |
0 |
0 |
24 h |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
48 h |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
72 h |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Average score |
0 |
0 |
0 |
0 |
0 |
0 |
0.3 |
0 |
0 |
0 |
0 |
0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
No classification is warranted according to CLP (1272/2008/EC) classification criteria for irritation/corrosion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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