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Diss Factsheets
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EC number: 203-450-8 | CAS number: 106-99-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: sediment simulation testing
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is readily biodegradable
- Endpoint:
- biodegradation in water: simulation testing on ultimate degradation in surface water
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Episuite and the BioHCWin model are well documented and commonly used QSARs for predicting the biodegradation potential of chemicals. Substances within LOA fall within the applicability domain of these models and they have been recommended by ECHA in the Information Requirement Guidelines.
- Qualifier:
- according to guideline
- Guideline:
- other: ECHA Information Requirements R.6
- Principles of method if other than guideline:
- BioHCwin v1.01 in EPISuite 4.1 (2013). The BioHCwin program was developed specifically for the biodegradation half-life prediction of petroleum hydrocarbons. Primary biodegradation half-lives for individual petroleum hydrocarbons are estimated using multiple linear regression against distinct molecular fragments, using a similar approach to several other biodegradation models such as those within the Biodegradation Probability Program (Biowin).
- Compartment:
- water
- DT50:
- 2.8 d
- Type:
- not specified
- Remarks on result:
- other: BioHCWin prediction
- Transformation products:
- not measured
- Conclusions:
- The results of the BioHCwin predictions for 1,3-butadiene indicate that it will degrade rapidly, with an estimated half life of 2.8 days.
- Executive summary:
As 1,3 -butadiene is a gas at standard temperature and pressure conducting a standard ready biodegradability test is technically difficult and based on exposure estimates the test may not be relevant. Therefore, the use of a QSAR to predict the biodegradability of 1,3 -butadiene is an appropriate technique to use a part of a weight of evidence approach. The use of BioHCwin is appropriate for 1,3-butadiene as this compound falls within the applicability domain of the model. The results indicate that 1,3 -butadiene is expected to biodegrade rapidly, with an estimated half-life of 2.8 days.
Referenceopen allclose all
Description of key information
As 1,3 -butadiene is a gas at standard temperature and pressure conducting a standard ready biodegradability test is technically difficult and based on exposure estimates the test may not be relevant. Therefore, the use of a QSAR to predict the biodegradability of 1,3 -butadiene is an appropriate technique to use a part of a weight of evidence approach. The use of BioHCwin is appropriate for 1,3-butadiene as this compound falls within the applicability domain of the model. The results indicate that 1,3 -butadiene is expected to biodegrade rapidly, with an estimated half-life of 2.8 days.
Biodegradation in sediment tests do not need to be conducted, since 1,3-butadiene is readily biodegradable in water.
Key value for chemical safety assessment
- Half-life in freshwater:
- 2.8 d
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.