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Diss Factsheets
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EC number: 270-790-1 | CAS number: 68478-10-4 A complex combination of hydrocarbons obtained by the distillation of debenzenized light steam-cracked naphtha. It consists predominantly of cyclic olefinic and aromatic hydrocarbons having carbon numbers predominantly in the range of C8 through C16 and boiling in the range of approximately 130°C to 300°C (226°F to 572°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Non human information
In the key study, sensitisation potential of dicyclopentadiene 75% was investigated in female guinea pigs in a modified (9 -induction) Buehler test, according to OECD guideline 406. Guinea pigs were dermally exposed to 0.5 mL undiluted dicyclopentadiene 75% for each of 9 induction phases (Safepharm, 1989e). Scattered mild redness was commonly seen at the induction sites during the induction phase. Other adverse skin reactions were fissuring, dry, thickened, straw-coloured skin (possible hyperkeratinisation), loss of skin suppleness, superficial cracking of the skin and small superficial scattered scabs. These reactions sometimes precluded evaluation of erythema. Following challenge with 0.2 mL undiluted dicyclopentadiene 75%, no skin responses were noted in test or control animals at 24 or 48 hours after challenge. Dicyclopentadiene 75% was therefore considered to be a non-sensitiser to guinea pig skin.
In the supporting study (Litton Bionetics, 1976a), 8 guinea pigs were induced with 10 intracutaneous injections (3/week) of 0.1% dicyclopentadiene (0.05 – 0.1mL). No skin reactions were observed. Two weeks after the last dose, the animals were challenged by injection with 0.05mL of 0.1% dicyclopentadiene and skin reactions graded using the Draize scheme. Mild erythema was seen 24-48 h after administration of this challenge and this was evaluated as a negative response.
Human information
No relevant information
Migrated from Short description of key information:
Dicyclopentadiene is considered not to be a skin sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Non human information
There are no specific animal studies to assess respiratory sensitisation but a wide range of inhalation studies in a number of animal species have shown no evidence of respiratory sensitisation potential.
Human information
Very little information has been reported on the irritation effects of dicyclopentadiene in humans. However, in a study in volunteers to determine the human sensory response to dicyclopentadiene vapour and to determine the odour threshold (Kinkead et al, 1971) there was no evidence of respiratory sensitisation.
Migrated from Short description of key information:
There are no specific animal studies to assess respiratory sensitisation but there is no evidence of respiratory sensitisation from the existing animal and human studies with dicyclopentadiene.
Justification for classification or non-classification
Dicyclopentadiene was shown to be non-sensitising in a guideline skin sensitisation study in animals and therefore requires no classification under CLP.
Since there is no evidence for respiratory sensitisation in a range of inhalation studies in various animal species or in the limited documented human exposures, dicyclopentadiene is considered not to warrant classification under CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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