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EC number: 270-790-1 | CAS number: 68478-10-4 A complex combination of hydrocarbons obtained by the distillation of debenzenized light steam-cracked naphtha. It consists predominantly of cyclic olefinic and aromatic hydrocarbons having carbon numbers predominantly in the range of C8 through C16 and boiling in the range of approximately 130°C to 300°C (226°F to 572°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Carcinogenicity
Administrative data
Description of key information
Dicyclopentadiene has been shown to be non-genotoxic both in vitro and in vivo. These observations indicate that dicyclopentadiene is not expected to be a genotoxic
carcinogen.
Dicyclopentadiene has been examined in repeat dose inhalation and oral studies and shown low levels of toxicity. The liver and adrenals showed limited changes on histopathological examination, and the kidneys in male rats showed changes consistent with the accumulation of alpha-2-microglobulin, a male rat specific protein.
It is concluded that there are sufficient data to indicate that dicyclopentadiene does not pose a risk of genotoxic carcinogenicity. There are also data available to understand that the cellular changes arising from repeated administration of dicyclopentadiene to animals are limited and to conclude that dicyclopentadiene is unlikely to be carcinogenic. The changes in the male rat kidney are consistent with a male rat specific mechanism and even if tumours were formed on chronic administration to male rats, these would be considered not relevant to humans.
The conduct of animal carcinogenicity studies is therefore considered to be unwarranted.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- see discussion
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- see discussion
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
No classification is warranted under CLP.
Additional information
There are no lifetime animal studies available on dicyclopentadiene in order to directly investigate for possible carcinogenic activity. However, there is sufficient information available to make an assessment of the likely carcinogenic potential of the material.
Non-testing information relevant for carcinogenicity
Dicyclopentadiene is a relatively straightforward chemical structure. It contains two olefinic centres, but sufficiently distant as to be essentially two isolated mono-ene groups. These are potential centres of chemical functional activity and the only alert for possible genotoxic activity when the structure of dicyclopentadiene is considered against the criteria established by Ashby and Tennant (1988).
Testing data relevant for carcinogenicity
In vitro data
Dicyclopentadiene has been examined for mutagenicity in a range of recognised core assay types. In vitro studies include assays for gene mutation in bacteria (the Salmonella mutation assay) and also for cytogenetic activity. It has shown negative results for mutagenicity in all these assays. The above assays would be considered appropriate for evaluating any activity that might have arisen from the two centres containing double bonds, and this indicates that the initial theoretical alert from consideration of the chemical structure is not expressed in reality. It is concluded that the available data indicate that dicyclopentadiene has no significant genotoxicity.
Animal data
A material containing dicyclopentadiene has been examined for mutagenicity using a bone marrow cytogenetic assay in the mouse and was found not to be mutagenic. Dicyclopentadiene has therefore been examined in the key relevant mutagenicity assays both in vitro and in vivo and found to be non-genotoxic. There is therefore good evidence for dicyclopentadiene being non-carcinogenic in animals with respect to a genotoxic mechanism.
The repeat dose toxicity of dicyclopentadiene was examined in F344 rats and B6C3F1 mice by the inhalation route for 13 weeks, 5 days/week, 6 hours/day, at doses of 0, 5.4, 27.5 and 275mg/m3 (Bushy Run, 1982). No toxicity was reported in the female rats. In the male rats, histopathological examination of the kidneys revealed dose-dependent changes consistent with the accumulation of alpha2u-globulin, a male rat specific protein. The only significant toxicity reported in the mice was deaths that were seen at the top dose group, accompanied by congestion of the lungs and kidney failure.
Dicyclopentadiene has also been examined in SD(Crj:CD) rats in an OECD screening test for combined repeat dose and reproductive/development toxicity. Doses used were 0, 4, 20, 100 mg/kg/day. In males, histopathological examination showed hyaline droplets and basophilic change in the tubular epithelium of the kidneys together with single cell necrosis in the liver. In both male and female animals an increase of fatty droplets was observed in the fascicular zone in the adrenals. No treatment related haematological changes were observed (JETOC, 1998a).
Similar findings of limited or no toxicity were reported in a range of other repeat dose studies, albeit with limited protocol features (e.g. animal numbers) or duration of exposure (e.g. Kinkead et al, 1971).
References
Ashby J and Tennant RW (1988) Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S.NCI/NTP. Mutat Res 204: 17-115.
SIDS (1998)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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