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EC number: 293-187-5 | CAS number: 91052-28-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Sediment toxicity
Administrative data
Link to relevant study record(s)
Description of key information
The chemical safety assessment according to Annex I of Regulation (EC) No. 1907/2006 does not indicate the need to investigate further the toxicity to sediment organisms.
Key value for chemical safety assessment
Additional information
No experimental data evaluating the toxicity to sediment organisms is available for Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri- (CAS No. 91052-28-7). Since the substance is readily biodegradable, exposure of sediment organisms is unlikely. Furthermore, the substance showed no toxicity to fish and aquatic invertebrates up to the limit of water solubility. Low toxicity was reported for algae species, leading to a NOERL = 32 mg/L (nominal, loading rate). Nevertheless, since the effects are above the water solubility of the substance, physical effects due to interference or adsorption of the substance to algae cells cannot be excluded. In addition, available data indicate,that Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri-is not bioaccumulative. Based on the available information, toxicity to sediment organisms is not expected to be of concern.
Intrinsic properties and fate
Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri- is readily biodegradable. According to the Guidance on information requirements and chemical safety assessment, Chapter R.7b, readily biodegradable substances can be expected to undergo rapid and ultimate degradation in most environments, including biological Sewage Treatment Plants (STPs) (ECHA, 2008). Therefore, after passing through conventional STPs, only low concentrations of these substances are likely to be (if at all)released into the environment.
Furthermore, the substance exhibits a log Kow value > 4.65 and is insoluble in water (< 0.05 mg/L). The Guidance on information requirements and chemical safety assessment, Chapter R7.b (ECHA, 2008) states that once insoluble chemicals enter a standard STP, they willbe extensively removed in the primary settling tank and fat trap and thus, only limited amounts will get in contact with activated sludge organisms. Nevertheless, once this contact takes place, these substances are expected to be removed from the water column to a significant degree by adsorption to sewage sludge (Guidance on information requirements and chemical safety assessment, Chapter R.7a, (ECHA, 2008)) and the rest will be extensively biodegraded (due to ready biodegradability). Thus, discharged concentrations of these substances into the aqueous/sediment compartment are likely to be negligible.
Considering this, one can assume that the availability of Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri- in the sediment environment is generally very low, which reduces the probability of exposure of sediment organisms in general.
Aquatic ecotoxicity data
Acute and chronic aquatic toxicity tests performed on fish and aquatic invertebrates showed no adverse effects occurred in the range of the water solubility of the substance(< 0.05 mg/L). Low toxicity was reported for algae species, leading to a NOERL (72 h) = 32 mg/L (nominal, loading rate). Nevertheless, since the effects are above the water solubility of the substance, physical effects due to interference or adsorption of the substance to algae cells cannot be excluded.
The obtained results indicate that Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri-is likely to show no or only low toxicity to sediment organisms as well.
Metabolism/Bioaccumulation
After absorption,Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri-is expected to be enzymatically hydrolyzed by carboxylesterases yielding the corresponding alcoholand fatty acids. QSAR estimations using BCFBAF v3.01 support the expected rapid biotransformation of this substance with BCF/BAF ranging from 0.89-56.7 L/kg.
The metabolism of the hydrolysisproducts: alcohol (i.e. glycerol) and fatty acids is well established and not of concern in terms of bioaccumulation. Glycerides, especially triglycerides, are the predominant lipid class in the diet of both marine and freshwater fish. Once ingested, they will be hydrolized into fatty acids and glycerol by a specific group of carboxylesterase (CaE) enzymes (lipases) as reported in different fish species (Tocher, 2003). Part of the free fatty acids will be re-esterified once more with glycerol and partial acyl glycerols to form triglycerides, which will be stored as long-term energy reserves. Glycerol is naturally present in animal and vegetable fats, rarely found in free state (mostly combined with fatty acids forming triglycerides) (ed. Knothe, van Gerpen and Krahl, 2005). If freely available in aquatic organisms, it will not bioaccumulate in view of its log Kow value of -1.76 (OECD SIDS, 2002). Especially in periods in which the energy demand is high (reproduction, migration, etc.), glycerides are mobilized from the storage sites as source of fatty acids. Fatty acid catabolism is the most important energy source in many species of fish, resulting in the release of acetyl CoA and NADH (through β-oxidation) and eventually, via the tricarboxylic cycle, the production of metabolic energy in the form of ATP. This fatty acid-catabolism pathway is the predominant source of energy related to growth, reproduction and development from egg to adult fish. A similar metabolic pathway is observed in mammals (see section 7.1.1 Basic toxicokinetics).
In conclusion, no potential for bioaccumulation is to be expected forGlycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri-.
Conclusion
Due to its readily biodegradable nature, extensive degradation of this substance in conventional STPs will take place and only low concentrations are expected to be released (if at all) into the environment. Once present in the aquatic compartment, further biodegradation will occur and, due to the high log Kow, low water solubility and high adsorption potential,Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri-will be bioavailable to sediment organisms mainly via feed and contact with suspended organic particles.After uptake by sediment species, extensive and fast biotransformation of the substance by carboxylesterases into fatty acids and glycerol is expected. The supporting BCF/BAF values estimated with the BCFBAFv3.01 program, Arnot-Gobas model including biotransformation, also indicate that this substance will not be bioaccumulative (0.89-56.7 L/kg). Furthermore, based on aquatic toxicity data, the toxicity to aquatic organisms is expected to be low. Therefore,Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri-is unlikely to pose a risk for sediment organisms in general and testing is thus omitted.
A detailed reference list is provided in the technical dossier (see IUCLID, section 13) and within the CSR.
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