Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 227-033-5 | CAS number: 5613-46-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 48-h EC50 is 3.1 mg/L in aquatic invertebrates (D. magna).
Key value for chemical safety assessment
Additional information
A GLP compliant study was performed, according to OECD guideline 202, to estimate the acute toxicity (EC50) of tetramethyl bisphenol A to Water Fleas (Daphnia magna) under static test conditions. Based on a preliminary test and consultation with the study sponsor, nominal concentrations of 0.31, 0.63, 1.3, 2.5, 5.0 and 10 mg/L were selected for the definitive exposure. Daphnids, less than 24 hours old, were impartially selected and distributed to intermediate vessels. Each test concentration contained 4 replicate test vessels with 5 daphnids per vessel for a total of 20 daphnids per exposure concentration.The test was initiated when the daphnids from each intermediate vessel were added to each exposure vessel.The number of immobilized daphnids in each replicate test vessel was recorded at 0, 24 and 48 hours of exposure. Biological observations and observations of the physical characteristics of each replicate test solution were also made and recorded at 0, 24 and 48 hours. The pH, dissolved oxygen concentration and temperature were measured at 0 and 48 hours. Following 24 hours of exposure, immobilization of 5, 0, 0, 0, 25, and 80% was observed among daphnids exposed to the 0.32, 0.48, 1.2, 2.3, 4.9, and 9.2 mg/L treatment levels, respectively. Three daphnids exposed to the 2.3 mg/L treatment level were observed to be lethargic. Several daphnids exposed to the 4.9 mg/L treatment level were observed to be lethargic. Several daphnids exposed to the 4.9 and 9.2 mg/L treatment level were observed to be on the bottom of the test vessel. Following 48 hours of exposure 5, 0, 5, 10, 100 and 100% immobilization was observed among daphnids exposed to the 0.32, 0.48, 1.2, 2.3, 4.9 and 9.2 mg/L treatment levels, respectively. The immobilization (5%) observed in the 0.32 mg/L treatment level, is not considered an adverse response from exposure to the test substance as the next higher concentration (i.e. 0.48 mg/L) was observed to have no effect. No immobilization or adverse effects were observed among daphnids exposed to the 0.48 mg/L treatment level, control or the solvent control. Several daphnids exposed to the 2.3 mg/L treatment level were observed to be lethargic. The calculated 24 and 48 hour EC50 (95% confidence intervals) values were 6.5 mg/mL (4.7-8.9 mg/L) and 3.1 mg/L (2.7 – 3.5 mg/L), respectively. The No-observed-effect concentration (NOEC) was determined to be 0.48 mg/L. The highest concentration producing 0% toxicant related immobilization was 0.48 mg/L and the lowest concentration producing 100% immobilization was 4.9 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)