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EC number: 236-793-7 | CAS number: 13483-58-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-05-09 to 2016-07-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995-07-27
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- column elution method
- Key result
- Water solubility:
- 10 - 500 µg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 6.3
- Conclusions:
- The water solubility of N,N'-[(methylimino)bis(trimethylene)]bis(stearamide) is reported to be in a range from 10 μg/L to 500 μg/L at 20 °C.
- Executive summary:
Water solubility of N,N'-[(methylimino)bis(trimethylene)]bis(stearamide) was determined according to OECD Guideline 105 (27 July 1995) using the column elution method.
It was not possible to obtain concentration plateaus for the experiments.
Furthermore higher concentrations of the test item were observed in the slower runs and the determined concentrations show some variation within and especially between the runs.
Due to these differences the flask method was tried for the less soluble test item, too.
The determined concentrations range from 30 μg/L to 244.8 μg/L. However, at these low concentrations this has to be regarded as acceptable.
To allow for these uncertainties, the water solubility has to be given as the range from 10 μg/L to 500 μg/L at 20 °C and a pH of 6.3.
Reference
The table below shows that the determination of the water solubility at a flow rate of 12.5 mL/h yielded values of 10μg/L.
At a flow rate of 6.25 mL/h no concentration plateau was reached. The determined concentrations range from 60μg/L to 180μg/L.
Flow rate [mL/h] |
Fraction No. |
Volume of combined fractions [ml] |
Test Item [μg/500 μL]
|
Test Item [μg/L]
|
12.5 |
1 (1-2) |
20 |
0.2 |
10 |
|
2 (3-4) |
20 |
0.2 |
10 |
|
3 (5-6) |
20 |
0.2 |
10 |
|
4 (7-8) |
20 |
0.2 |
10 |
|
5 (9-10) |
20 |
0.2 |
10 |
|
6 (11-12) |
20 |
0.2 |
10 |
|
7 (13-14) |
20 |
0.2 |
10 |
|
8 (15-16) |
20 |
0.2 |
10 |
|
|
|
|
|
6.25 |
1 (1-2) |
20 |
2.8 |
140 |
|
2 (3-4) |
20 |
1.7 |
85 |
|
3 (5-6) |
20 |
1.8 |
90 |
|
4 (7 -8) |
20 |
1.6 |
80 |
|
5 (9-10) |
20 |
3.6 |
180 |
|
6 (11-12) |
20 |
1.5 |
75 |
|
7 (13-14) |
20 |
1.2 |
60 |
|
8 (15-16) |
20 |
1.3 |
65 |
According to OECD 105, the flow rate has to be further decreased if the values in the slower run increase. The results of this slower run are summarised in the table below:
Flow rate [mL/h] |
Fraction No. |
Volume of combined fractions [ml] |
Test Item [μg/500 μL]
|
Test Item [μg/L]
|
6.25 |
1 (1-2) |
20 |
2.6 |
130 |
|
2 (3-4) |
20 |
2.9 |
145 |
|
3 (5-6) |
20 |
2.1 |
105 |
|
4 (7-8) |
20 |
2.2 |
110 |
|
5 (9-10) |
20 |
1.4 |
70 |
|
6 (11-12) |
20 |
1.1 |
55 |
|
7 (13-14) |
20 |
1.1 |
55 |
|
8 (15-16) |
20 |
1.0 |
50 |
|
|
|
|
|
3.125 |
1 (1-2) |
20 |
8.1 |
405 |
|
2 (3-4) |
20 |
5.4 |
270 |
|
3 (5-6) |
20 |
3.5 |
175 |
|
4 (7-8) |
20 |
3.6 |
180 |
|
5 (9-10) |
20 |
2.7 |
135 |
|
6 (11-12) |
20 |
6.5 |
325 |
|
7 (13-14) |
20 |
6.6 |
330 |
|
8 (15-16) |
20 |
10.0 |
500 |
lt was not possible to obtain concentration plateaus for the experiments.
Furthermore higher concentrations of the test item were observed in the slower runs and the determined concentrations show some variation within and especially between the runs.
Due to these differences the flask method was tried for the less soluble test item, too.
The determined concentrations range from 30μg/L to 244.8μg/L. However, at these low concentrations this has to be regarded as acceptable.
To allow for these uncertainties, the water solubility has to be given as the range from 10 μg/L to 500 μg/L.
The water solubility was determined at 20 °C. The pH value of the collected aqueous fractions was 6.3.
Description of key information
The water solubility of N,N'-[(methylimino)bis(trimethylene)]bis(stearamide) is reported to be in a range from 10 μg/L to 500 μg/L at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 500 µg/L
- at the temperature of:
- 20 °C
Additional information
Water solubility of N,N'-[(methylimino)bis(trimethylene)]bis(stearamide) was determined according to OECD Guideline 105 using the column elution method.
It was not possible to obtain concentration plateaus for the experiments. Furthermore higher concentrations of the test item were observed in the slower runs and the determined concentrations show some variation within and especially between the runs.
Due to these differences the flask method was tried for the less soluble test item, too.
The determined concentrations range from 30 μg/L to 244.8 μg/L. However, at these low concentrations this has to be regarded as acceptable.
To allow for these uncertainties, the water solubility has to be given as the range from 10 μg/L to 500 μg/L at 20 °C and a pH of 6.3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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