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Diss Factsheets
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EC number: 265-222-4 | CAS number: 64754-95-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.1 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 1 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.01 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- no hazard identified
Sediment (freshwater)
- Hazard assessment conclusion:
- no hazard identified
Sediment (marine water)
- Hazard assessment conclusion:
- no hazard identified
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no exposure of soil expected
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
The PNECs were derived using freshwater experimental ecotoxicity results for lithium myristate, lithium 12-hydroxystearate and lithium myristate (Harlan 2013), which are considered reliable studies for these endpoints and scored as either Klimisch 1 or 2 (Klimisch et al 1997).
The aquatic PNECs have been derived using results from studies on the acute toxicity to Daphnia and fish and algal growth inhibition for lithium myristate, lithium 12-hydroxystearate and lithium behenate. These proprietary studies were conducted as water accommodated fractions at a GLP-compliant laboratory following OECD guidelines in standard water with a hardness of approximately 150 mg/L CaCO3. The studies showed no effects at up to 100 mg/L. Algal studies report both acute and chronic endpoints, therefore the algal growth inhibition studies provide chronic data for this trophic level, with the lowest NOErLR = 100 mg/L. However, REACH guidance requires either fish or daphnid chronic data be used in conjunction with algae chronic results to calculate PNECs using a less restrictive assessment factor. Therefore, aquatic PNECs have been derived based on acute toxicity results. The results from the acute aquatic studies and the appropriate assessment factors were used to derive conservative PNEC values for freshwater, marine water and intermittent freshwater release.
The substances show no toxicity at their limit of solubility, have vapour pressures of less than 10 E-10 Pa and a low potential for bioaccumulation or adsorption, and are readily biodegradable and not applied directly to soil. Therefore, the STP, sediment, soil, secondary poisoning and air PNECs were not derived due to a lack of potential exposure or a lack of identified hazard.
References
Klimisch HJ, Andreae M, Tillmann U (1997) A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data. Regulatory toxicology and pharmacology, vol. 25, pp. 1 -5
Conclusion on classification
None of the substances in the lithium salts of monocarboxylic acids C14-C22 category showed acute toxicity to aquatic organisms at up to 100 mg/L WAF and therefore they do not meet the criteria for classification as acutely toxic to the aquatic environment under the DSD or the CLP.
Chronic aquatic toxicity data for lithium salts of monocarboxylic acids C14-C22 are only available for algae. These data would not result in a chronic classification under the 2ndATP to the CLP. All of the substances in the category are considered to be readily biodegradable, with a low potential for bioaccumulation. As the substances do not show acute toxicity at up to 100 mg/L, none of the substances in the lithium salts of monocarboxylic acids C14-C22 category meet the criteria for chronic toxicity to aquatic organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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