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Diss Factsheets
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EC number: 701-308-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Based on read-across from a structural analogue (Modified Small Vinyl Ester) is concluded that Small Vinyl Ester will induce less than 30% immobility in Daphnia at its water solubility limit, which is approximately 0.42 mg/L based on the solubility of main constituent bisGMA.
Key value for chemical safety assessment
Additional information
The read-across analogue Modified Small Vinyl Ester was tested for short-term toxicity in invertebrates according to REACH Annex VII section 9.1.1 (Daphnia sp. acute immobilisation test; EU Method C.2), applying the OECD Guideline 202. The study met the acceptability criteria prescribed by the protocol and was considered valid. Under the conditions of the test, Modified Small Vinyl Ester induced not more than 30% immobility in Daphnia magna at the water solubility limit of Modified Small Vinyl Ester, being approximately 7 mg/L weighted average for the two main constituents, bisGMA (0.42 mg/L) and monomaleic-bisGMA (37.6 mg/L). Hence, the 48h-EC50 for Modified Small Vinyl Ester was above the water solubility limit (7 mg/L). Small Vinyl Ester does not contain monomaleic-bisGMA. The water solubility limit for Small Vinyl Ester is approximately 0.42 mg/L based on bisGMA. It is evaluated that the result and conclusion for Modified Small Vinyl Ester is valid also for Small Vinyl Ester based on the chemical similarity. Using read-across from Modified Small Vinyl Ester to Small Vinyl Ester it is concluded that the acute toxicity of Small Vinyl Ester (48h-EC50) is higher than the water solubility for Small Vinyl Ester (0.42 mg/).
Based on the chemical similarity of Small Vinyl Ester and Modified Small Vinyl Ester, the fact that Modified Small Vinyl Ester, which is more water soluble than Small Vinyl Ester, has low toxicity, corroborates the fact that Small Vinyl Ester has no or little toxicity to Daphnia, as a higher water solubility would result in a higher concentration in water and thus in a higher exposure concentration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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