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EC number: 200-431-6 | CAS number: 59-50-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: reporting deficiencies, no purity provided
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- no guideline followed
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted in 1987
- Deviations:
- yes
- Remarks:
- environmental conditions and pathology findings not reported, only male rats, acclimatisation period of 3 instead of 5 days
- Principles of method if other than guideline:
- In fact no guideline was reported in the study; the test conduct, however, was in principle similar to the OECD TG 401.
- GLP compliance:
- no
- Test type:
- other: acute oral toxicity
- Limit test:
- no
Test material
- Reference substance name:
- Chlorocresol
- EC Number:
- 200-431-6
- EC Name:
- Chlorocresol
- Cas Number:
- 59-50-7
- Molecular formula:
- C7H7ClO
- IUPAC Name:
- 4-chloro-3-methylphenol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar (Strain Bor: WISW (SPF Cpb))
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Age at study initiation: young adult
- Weight at study initiation: 160 - 180 g
- Housing: 5 animals per cage
- Acclimation period: 3 days
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Remarks:
- PEG 400
- Doses:
- 1000, 1500, 2000, 3150, 3100 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were conducted on the day of treatment and twice each working day and once daily on weekends. Surviving animals were weighed before treatment, after one week and at study termination.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 830 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 470 - <= 2 260
- Mortality:
- 1500 mg/kg bw/day: 4/10 males died (2 - 7 d post-dose)
2000 mg/kg bw/day: 7/10 males died (3 h - 2 d post-dose)
3100 mg/kg bw/day: 8/10 males died (3 h - 2 d post-dose)
5000 mg/kg bw/day: 10/10 males died (1 h post-dose) - Clinical signs:
- other: all animals in all dose groups: increased diuresis, sedation, respiratory disturbance, side position, tremor and tonical cramps
- Gross pathology:
- Not specified.
Any other information on results incl. tables
Table 1: Results of acute oral toxicity testing in male rats
Dose [mg/kg bw] |
Toxicological results* |
Time of death |
Mortality (%) |
1000 |
0/10/10 |
- |
0 |
1500 |
4/10/10 |
2 d - 7 d |
40 |
2000 |
7/10/10 |
3 h - 2 d |
70 |
3100 |
8/10/10 |
3 h - 2 d |
80 |
5000 |
10/10/10 |
1 h |
100 |
* number of dead animals/ number of animals with signs of toxicity/ number of animals used
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- CLP: Acute Oral 4, H302
- Executive summary:
A study for acute oral toxicity in the rat was conducted with the test substance. 10 male Wistar rats per group received 1000, 1500, 2000, 3100 and 5000 mg/kg bw test substance as a solution in Polyethyleneglycol 400 as vehicle by single-dose oral gavage. Observations were made frequently on the day of treatment and twice each working day and once daily on weekends throughout the two-week observation period. Surviving animals were weighed before treatment, after one week and at study termination. Pathological-anatomical examinations were performed on all animals. The clinical signs observed were increased diuresis, sedation, respiratory disturbance, side position, tremor and tonical cramps. All animals died in the highest dose group within 1 h after application. Mortalities of animals at the dose groups 2000 and 3100 mg/kg bw/day (7/10 and 8/10 males died, respectively) occurred between 3 h and 2 d post-dosing. 4/10 animals died at 1500 mg/kg bw at 2 – 7 d after test substance administration. No mortalities occured at 1000 mg/kg bw/day. Clinical signs in all animals at all dose groups included increased diuresis, sedation, respiratory disturbance, side position, tremor and tonical cramps. Under the conditions of this study the LD50 was considered to be 1830 mg/kg bw for male rats. According to Regulation (EC) No 1272/2008 the test material needs to be classified with respect to the oral route with Acute Tox. 4; H302.
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