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Diss Factsheets
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EC number: 215-200-5 | CAS number: 1312-81-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Summary Genotoxicity:
Lanthanum oxide was negative in a standard bacterial gene mutation assay with S. typhimurium TA1535, 1537, 98, 100 and 102 (Sokolowsky 2006) with and without a metabolic activation system. The soluble Lanthanum derivative Lanthanum nitrate hexahydrate was also reported to be negative in a bacterial assay with S. thyphimurium strains TA100, TA1535, TA97 and TA98 (Zeiger et al., 1992), suporting the negative effect of lanthanum ions in this test system Several other mutagenicity studies are available for the lanthanum carbonate. These are considered relevant for lanthanum oxide as well due to the similarly low water solubility of both substances. Lanthanum carbonate was negative in a mammalian gene mutation assay (HPRT-locus) in Chinese Hamster Ovary cells and a bacterial gene mutation assay in TA1535, TA1537, TA1538, TA98, TA100, TA102) and E. coli WP2 uvrA and WP2 uvrA (pkm101) both with and without metabolic activation (Damment et al. 2005). An in vitro cytogenetic assay in Chinese Hamster ovary cells with lanthanum carbonate was equivocal. Apparent positive findings at some concentrations were attributed to cytotoxicity and precipitation of the test substance (Damment et al. 2005).. An in vivo oral mouse bone marrow micronucleus test in CD-1 mice with lanthanum carbonate was negative (non mutagenic) (Damment et al. 2005). Several studies have also been performed with lanthanum chloride. As a the chloride is soluble lanthanum salt these are representative for testing La3+genotoxicity. Lanthanum chloride was negative in a rat bone marrow micronucleus test after intravenous administration and in a rat liver in vivo/ex vivo UDS assay after 28-day repeated intravenous administration (Damment et al. 2005).
From the results of these tests it can be concluded that lanthanum compounds, including lanthanum oxide are not genotoxic and not clastogenic.
Short description of key information:
From available valid in vitro and in vivo data with lanthanum compounds it can be concluded that lanthanum oxide is not genotoxic and not clatogenic.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Due to the negative results in in vitro and in vivo genotoxicity studies with lanthanum compounds no classification for genotoxicity is warranted.
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