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EC number: 828-229-9 | CAS number: 7019-19-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Sept-Oct 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- This is a Klimisch 1 rated GLP study conducted on the registered substance
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Lot/Batch 1203/16/100
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- Activated sludge from the municipal wastewater treatment plant Breisgauer Bucht was used as test system. The treatment plant has a capacity of 600 000 inhabitant equivalents and clarifies predominantly domestic wastewater. Sampling date of activated sludge was 25 September 2018. The activated sludge was kept aerated until use at test temperature. The activated sludge was washed twice by settling the sludge, decanting the supernatant and re-suspending the sludge in chlorine-free tap water. Dry solid of the activated sludge was determined as 3.9 g/L by weight measurements before and after drying at 105°C (mean of triplicate measurements).
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- ThOD
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- In total three reactors containing the test item, three reactors containing only inoculum (blank), three reactors containing the reference compound (reference) and one reactor containing reference compound and test item (toxicity control) were set up.
The test flasks were filled and tempered to the incubation temperature for one hour. Afterwards, 1.3 mL of the inoculum were added into each flask except the abiotic control, one sodium hydroxide pellet was added to each rubber quiver inserted in the flasks and the flasks were sealed tightly with the measuring heads and the test was started.
After 28 days the data were read out and the pH in the flasks was measured. - Reference substance:
- acetic acid, sodium salt
- Test performance:
- The oxygen uptake of the inoculum blank was in the range of 20 - 30 mg O2/L and did not exceed 60 mg O2/L in 28 days (presently 23.4 mg O2/L).
The pH value in the test and blank bottles was within the specified range of 6 – 8.5 (presently 7.6). In the reference and toxicity control vessels the pH was above 8.5, however the oxygen consumption in those vessels was greater than 60% within the test duration.
The difference of extremes of replicate values of the test item degradation extents was less than 20% (presently 2.5%).
The biodegradation of the reference item reached the pass level of 60% ThOD by day 8 (presently 71.2%).
The degradation extent in the toxicity control was above 25% in 14 days based on ThOD (presently 35.6% on day 4)
Taking all of the above into account the test is considered valid according to OECD Test Guideline 301 F (July 1992). - Parameter:
- % degradation (O2 consumption)
- Value:
- 48.7
- Sampling time:
- 4 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 65.6
- Sampling time:
- 8 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 72.1
- Sampling time:
- 12 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 74.1
- Sampling time:
- 16 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 75
- Sampling time:
- 20 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 74.2
- Sampling time:
- 24 d
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 76.8
- Sampling time:
- 28 d
- Details on results:
- The biodegradation of the test item was 76.8% within 28 days (mean of three replicates). On day 8 the degradation extent was already above 60% (65.6%, mean of three replicates) and the criterion for ready biodegradation is therefore met.
The degradation in the toxicity control reached a value higher than 25% within 4 days (35.6%). According to the validity criterion of the guideline OECD 301 the test item had no toxic or inhibitory effect to the inoculum. - Results with reference substance:
- The reference compound sodium acetate reached the pass level for ready biodegradability (60% ThOD within a 10-day window) within 8 days (71.2%).
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- On the basis of this test 1 -hydroxyoctan-2 -one is considered to be ready biodegradable meeting the 10d window.
- Executive summary:
An OECD 301F study was carried out in accordance with GLP to investigate the ready biodegradability of the registered substance 1 -hydroxyoctan-2 -one.
The biodegradation of the test item was 76.8% within 28 days (mean of three replicates). On day 8 the degradation extent was already above 60% (65.6%, mean of three replicates) and the criterion for ready biodegradation is therefore met.
The reference compound sodium acetate reached the pass level for ready biodegradability (60% ThOD within a 10-day window) within 8 days (71.2%).
The degradation in the toxicity control reached a value higher than 25% within 4 days (35.6%). According to the validity criterion of the guideline OECD 301 the test item had no toxic or inhibitory effect to the inoculum.
On the basis of this test 1 -hydroxyoctan-2 -one is considered to be ready biodegradable meeting the 10d window.
Reference
Day | %Biodegradation Test Item | Tox Control | %Biodegradation Ref Item | ||||||
Rep 1 | Rep 2 | Rep 3 | Mean | Rep 1 | Rep 2 | Rep 3 | Mean | ||
0 | 0 | 0 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0.0 |
4 | 48.7 | 48.7 | 48.7 | 48.7 | 35.6 | 54.3 | 57.1 | 54.3 | 55.2 |
8 | 64.7 | 64.7 | 67.5 | 65.6 | 48.1 | 70.3 | 73.1 | 70.3 | 71.2 |
12 | 71.2 | 71.2 | 74 | 72.1 | 59.6 | 76.9 | 76.9 | 76.9 | 76.9 |
16 | 73.1 | 73.1 | 76 | 74.1 | 69.2 | 78.8 | 81.3 | 78.8 | 79.6 |
20 | 74.1 | 74.1 | 76.9 | 75.0 | 73.7 | 79.4 | 79.4 | 79.4 | 79.4 |
24 | 75.1 | 72.3 | 75.1 | 74.2 | 75.3 | 80.6 | 77.6 | 77.6 | 78.6 |
28 | 77.6 | 75.1 | 77.6 | 76.8 | 78.3 | 83.6 | 80.6 | 77.6 | 80.6 |
Description of key information
An OECD 301F study was carried out in accordance with GLP to investigate the ready biodegradability of the registered substance 1 -hydroxyoctan-2 -one.
The biodegradation of the test item was 76.8% within 28 days (mean of three replicates). On day 8 the degradation extent was already above 60% (65.6%, mean of three replicates) and the criterion for ready biodegradation is therefore met.
The reference compound sodium acetate reached the pass level for ready biodegradability (60% ThOD within a 10-day window) within 8 days (71.2%).
The degradation in the toxicity control reached a value higher than 25% within 4 days (35.6%). According to the validity criterion of the guideline OECD 301 the test item had no toxic or inhibitory effect to the inoculum.
On the basis of this test 1 -hydroxyoctan-2 -one is considered to be ready biodegradable meeting the 10d window.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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