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Diss Factsheets
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EC number: 500-097-4 | CAS number: 37353-75-6 1 - 4.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- other: Assessment of the relevance of long-term toxicity testing on aquatic invertebrates
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Assessment of the relevance of long-term toxicity testing on aquatic invertebrates
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Assessment of the relevance of long-term toxicity testing on aquatic invertebrates
- GLP compliance:
- no
- Remarks on result:
- other: Assessment of the relevance of long-term toxicity testing on aquatic invertebrates
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- An assessment was performed on the relevance of performing long-term toxicity testing on aquatic invertebrates for the registered substance. As a result of this assessment and in accordance with Annex IX of REACH, it is concluded that no long-term toxicity testing on aquatic invertebrates is required.
- Executive summary:
In accordance with Annexes IX, Column 2, of REACH, long-term toxicity testing shall be proposed by the registrant if the CSA conducted in accordance to Annex I indicates the need to investigate further the effects on aquatic organisms. The choice of the appropriate test(s) depends on the results of the CSA.
An assessment of the environmental exposure to BPA PO and its hazardous properties was conducted as part of the CSA performed in accordance with Annex I of REACH. As part of this assessment seven exposure scenarios were considered.
The Risk Characterisation Ratios (RCRs) were calculated using the PNEC derived from the results of short-term toxicity testing performed on freshwater species. These results were obtained applying the most conservative assessment factor (1,000 for freshwater species and 10,000 for marine species) because of the lack of long-term studies. Despite the use of the greatest assessment factor available the RCRs are below 1.
The substance carries a classification of Aquatic Chronic 2; H411 based on the EC50 of aquatic invertebrates (48h EC50 = 2.3 mg/L) and the lack of ready biodegradability in accordance with Regulation (EC) No.1272/2008 on the Classification, Labelling and Packaging of Substances and Mixtures. However, this classification takes into account the inherent properties of the substance as such, whereas a RCR takes also into account public and environmental exposure to the chemical, in part determined by usage. Therefore, a risk based approach is considered more appropriate to determine if the hazardous properties of the substance to the aquatic environment will require further testing (UK Royal Society of Chemistry (2007), Hansson et al. (2011) and Lofstedt (2013)). Based on the calculated RCRs BPA PO is not expected to pose a significant risk to the aquatic environment and therefore no further long-term toxicity testing to aquatic species is required.
The CSA shows no concern related to the long-term toxicity of BPA PO to the aquatic environment that can justify additional testing to be performed on aquatic species.
It can therefore be concluded that the CSA does not indicate the need to investigate further the effects on aquatic invertebrates.
Reference
Description of key information
An assessment of the environmental exposure to BPA PO and its hazardous properties was conducted as part of the CSA performed in accordance with Annex I of REACH. Seven exposure scenarios were considered.
The Risk Characterisation Ratios (RCRs) were calculated for all exposure scenarios using the PNEC derived from the results of short-term toxicity testing performed on freshwater species and are below 1. A risk based approach is considered appropriate to determine if the hazardous properties of the substance to the aquatic environment will require further testing. Based on the calculated RCRs BPA PO is not expected to pose a significant risk to the aquatic environment and therefore no further long-term toxicity testing to aquatic species is required.
The CSA shows no concern related to the long-term toxicity of BPA PO to the aquatic environment that can justify additional testing to be performed on aquatic species.
It can therefore be concluded that the CSA does not indicate the need to investigate further the effects on aquatic invertebrates.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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