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EC number: 204-018-1 | CAS number: 112-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Skin Irritation
Not irritating to the skin
Ocular Irritation
Not irritating to eyes
Respiratory Irritation
No studies were located to indicate that Icosane is a respiratory irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- from 1998/09/14 to 1998/09/25
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted according to OECD guideline N°404 in compliance with GLP. Substance analytical certificate not available
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Guideline study
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- other: SPF
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Russian from Mollegaard Breeding and Research Centre A/S, Ejby, DK-4623 Lille Skensved.
- Age at study initiation: no data
- Weight at study initiation: 2.1-2.5 kg
- Housing: individually
- Diet (e.g. ad libitum): A pelleted complete rabbit "Altromin 2123" diet ad libitum
- Water (e.g. ad libitum): tap water
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 3°C
- Humidity (%): 55 ± 15%
- Air changes (per hr): 10 times/hour
- Photoperiod (hrs dark / hrs light): 12 h/ 12h
IN-LIFE DATES: no data - Type of coverage:
- semiocclusive
- Preparation of test site:
- other: Electric clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL, undiluted - Duration of treatment / exposure:
- 4 hours
- Observation period:
- Skin reaction assessed at 1, 24, 48 and 72 hours and 7 days after exposure (after the removal of the patch)
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: ca. 2.5 cm X 2.5 cm (left+ right)
- % coverage: no data
- Type of wrap if used: Nobifix (6 cm width) was loosely wound round the trunk
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the test substance was cleaned with lukewarm water and mild soap
- Time after start of exposure: 4 hours
SCORING SYSTEM: in accordance with the OECD guideline 404 - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- See Table I, the test substance is slightly irritating:
- The mean individual erythema scores were 0.2, 0.3 and 0.5 respectively
- The mean individual oedema scores were 0.7, 0.0 and 0.0 respectively - Other effects:
- none
- Interpretation of results:
- other: Not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions, DEV 98-25 is not classified as skin irritant according to the criteria of Annex VI of the Directive 67/548/EEC and CLP Regulation 1272/2008.
- Executive summary:
In a primary dermal irritation study conducted according to OECD guideline N°404, three rabbits were exposed to 0.5 mL of DEV 98-25 at two skin sites on the back.
Test sites were covered with a semi-occlusive dressing for 4 hours. Animals then were observed for 7 days. The skin reactions were assessed at 1, 24, 48 and 72 hours, as well as 7 days after removal of the dressing. The mean score was calculated across 3 scoring times; 24, 48 and 72 hours after patch removal, for each animal separately.
The mean individual scores were 0.2, 0.3 and 0.5 for erythema and 0.7, 0.0 and 0.0 for edema.
Based upon the directive 67/548/EEC and the CLP Regulation 1272/2008, DEV 98 -25 is not considered as irritating to the rabbit skin.
Reference
Table I: Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test
Score at time point / Reversibility |
Erythema |
Edema |
Max. score: 4 |
Max. score: 4 |
|
24 h |
L: 1/1/1 R: 0/1/1 |
L and R: 0/0/0 |
48 h |
L: 0/0/0 R: 0/0/1 |
L: 1/0/0 R: 1/0/0 |
72 h |
L: 0/0/0 R: 0/0/0 |
L: 1/0/0 R: 1/0/0 |
Average 24h, 48h, 72h |
L+R: 0.2 -0.3- 0.5 |
L and R: 0.7-0-0 |
Reversibility* |
C |
C |
Average time (unit) for reversion |
within 72 hours |
within 7 days |
L: left test flank R: right test flank C: completely reversible
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 28 September 1998 to 02 October 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline N°405, GLP but substance analytical certificate not available (Substance identification: code name with information on test substance).
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- age of animals at study initiation was not reported
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- age of animals at study initiation was not reported
- Principles of method if other than guideline:
- Guideline study
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- other: SPF albino rabbits of the stock Mol:Russian
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: M & B, Ejby, DK-4623 Lille Skensved, Denmark
- Age at study initiation: no data
- Weight at study initiation: 2.3 - 2.8 kg
- Housing: kept individually in PPO/HIPS cages (Noryl, floor area = 2576 cm²)
- Diet: pelleted complete rabbit diet "Altromin 2123" from Ch. Petersen ad libitum. Analysis for major nutritive components and relevant possible contaminations in the diet are performed regularly.
- Water: domestic quality drinking water acidified with hydrochloric acid to pH 2.5 ad libitum. Analyses for relevant possible contamination in the water are performed regularly.
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C +/- 3°C
- Humidity (%): 55% +/- 15%
- Air changes (per hr): 10
- Photoperiod :12 hrs dark /12 hrs light
IN-LIFE DATES: From: To: - Vehicle:
- not specified
- Controls:
- other: the right eye of the treated animals was used as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 mL - Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 1, 24, 48, 72 hours after application
- Number of animals or in vitro replicates:
- 3 females
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): with 20 mL 0.9% sodium chloride solution
- Time after start of exposure: 24 hrs
SCORING SYSTEM: grading according to OECD 405 recommendation
TOOL USED TO ASSESS SCORE: fluorescein, UV light - Irritation parameter:
- cornea opacity score
- Basis:
- other: mean individual score for all animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: See Table 1 for details
- Irritation parameter:
- iris score
- Basis:
- other: mean individual score for all animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Remarks on result:
- other: See Table 1 for details
- Irritation parameter:
- chemosis score
- Basis:
- other: mean individual score for all animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: See Table 1 for details
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #1 and #3 - Mean individual score
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: not applicable
- Remarks on result:
- other: See Table 1 for details
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Remarks:
- mean individual score
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 3
- Reversibility:
- other: not applicable
- Remarks on result:
- other: See Table 1 for details
- Irritant / corrosive response data:
- Irritant effects on conjunctiva (redness) were minimal at 1 hour in all animals and were fully reversed at 72h in all animals. There were no effects on the cornea and the iris at any time point. Chemosis was not observed at any time point in all animals.
It can be concluded that DV 98-25 would not be classified as eye irritant. - Other effects:
- No data
- Interpretation of results:
- other: Not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- under the test conditions, DV 98-25 is not classified as eye irritant according to the criteria of Annex VI of the Directive 67/548/EEC and the CLP Regulation 1272/2008.
- Executive summary:
The eye irritant effect of DV 98-25 was investigated according to the OECD Guideline No. 405 (1987) and EEC B.5 method (1992) and in compliance with Good Laboratory Practice.
Three female albino rabbits were exposed to 0.1 mL of the test article in the left eye. The eyes were examined and the changes were graded according to a numerical scale 1, 24, 48 and 72 hours after dosing.
Minimal conjunctival irritation (redness) was observed in the three rabbits 1 hour after dosing. During the rest of the observation period no abnormalities were observed for two animals while redness (score 1) was still observed up to 48 h in the third animal.
DV 98 -25 is not considered as irritating to the eyes according to Annex VI of the Directive 67/548/EEC and CLP Regulation 1272/2008.
Reference
Table 1: DV 98 -25 Acute eye irritation/corrosion study in the rabbit. Scores for ocular lesions.
Rabbit No / |
1 h |
24 hrs |
|
48 hrs |
72 hrs |
Individual mean score* |
||
weight (kg) |
F |
|||||||
3531 / 2.3 |
Cornea opacity, area |
0 |
0 |
0 |
0 |
0 |
|
|
Cornea opacity, degree |
0 |
0 |
0 |
0 |
0 |
0.0 |
||
Iris |
0 |
0 |
|
0 |
0 |
0.0 |
||
Conjunctiva |
Chemosis |
0 |
0 |
|
0 |
0 |
0.0 |
|
Redness |
1 |
0 |
|
0 |
0 |
0.0 |
||
Discharge |
3 |
0 |
|
0 |
0 |
|||
|
||||||||
3533 / 2.3 |
Cornea opacity, area |
0 |
0 |
0 |
0 |
0 |
|
|
Cornea opacity, degree |
0 |
0 |
0 |
0 |
0 |
0.0 |
||
Iris |
0 |
0 |
|
0 |
0 |
0.0 |
||
Conjunctiva |
Chemosis |
0 |
0 |
|
0 |
0 |
0.0 |
|
Redness |
1 |
1 |
|
1 |
0 |
0.7 |
||
Discharge |
3 |
0 |
|
0 |
0 |
|||
|
||||||||
3534 / 2.8 |
Cornea opacity, area |
0 |
0 |
0 |
0 |
0 |
|
|
Cornea opacity, degree |
0 |
0 |
0 |
0 |
0 |
0.0 |
||
Iris |
0 |
0 |
|
0 |
0 |
0.0 |
||
Conjunctiva |
Chemosis |
0 |
0 |
|
0 |
0 |
0.0 |
|
Redness |
1 |
0 |
|
0 |
0 |
0.0 |
||
Discharge |
3 |
0 |
|
0 |
0 |
0.0 |
F: Reading after instillation of oculoguttae fluoresceini.
* Only the scores from the 3 readings (24, 48 and 72 hours) are included in the calculation of the individual mean scores
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There is no skin or eye irritation data available for Icosane. However, data is available for structural analogues, Hydrocarbons, C14-C17, n-alkanes, <2% aromatics; Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics; Hydrocarbons, C16-C20, n-alkanes, isoalkanes, cyclics, <2% aromatics; and Isohexadecane. This data is read across to Icosane based on analogue read across and a discussion and report on the read across strategy is provided as an attachment in IUCLID Section 13.
Skin irritation
Thirteen reliable read across studies were available for structural analogues Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics; Hydrocarbons, C16-C20, n-alkanes, isoalkanes, cyclics, <2% aromatics and isohexadecane. All studies were conducted similarly or according to OECD guideline 404.All studies show no or slight irritation effects on rabbits' skin.
Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics
In a key primary dermal irritation study conducted according to OECD guideline N°404, three rabbits were exposed to 0.5 mL of the test material (Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics) at two skin sites on the back TOTAL Solvants, 1998). Test sites were covered with a semi-occlusive dressing for 4 hours. Animals then were observed for 7 days. The skin reactions were assessed at 1, 24, 48 and 72 hours, as well as 7 days after removal of the dressing. The mean score was calculated across 3 scoring times; 24, 48 and 72 hours after patch removal, for each animal separately. The mean individual scores were 0.2, 0.3 and 0.5 for erythema and 0.7, 0.0 and 0.0 for edema. Based upon the CLP Regulation 1272/2008, Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics is not considered as irritating to the rabbit skin.
Seven supporting read across studies that tested Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics (Carless, 1997a, b, c; Total Solvants 1996a, b; Anchor Drillin Fluids, 1995a, b) demonstrated that the substance is not considered as irritating to the rabbit skin.
Isohexdecane
In a supporting clinical test including 15 human volunteers, isohexadecane was applied undiluted on upper arm in occlusive conditions (patch) for 24 h (Hill Top Research, 1994). Skin reactions were scored 30 min and 24 h after removal of the patch. Mild signs of irritation were observed in only 3 volunteers and only slight signs of irritation in 8 volunteers in worse conditions (24-h exposure, occlusive conditions), leading to the conclusion that isohexadecane is not irritant for human skin.
The skin irritating properties of the substance BP solvent IH/isohexadecane was assessed in White Vienna rabbits (3 animals of both sexes). The test substance was applied on a wipe put in contact with the shaved skin under semi-occlusive dressing for 24 hours. At the end of exposure, skin reactions were recorded both at 24 hours (patch removal) and 48 hours after the end of exposure (i.e. 72 -hour time observation) according to the Draize scale. Complete observation time was 14 days.
Moreover, the behavior, general state and food consumption were also observed. Body weight was measured every day. There was a very slight erythema (score 1) in two rabbits at patch removal (observation time = 24h). At the 72-hour observation, no erythema was observed in all 6 animals. No oedema was noted in any animal at any observation time. No systemic effect was observed following exposure to BP Solvent IH/Isohexadecan. Behavior, general state, fur, food consumption and body weight development were normal (INEOS, 1980). Under these test conditions, the substance BP solvent IH/Isohexadecan is not classified as a skin irritant according to CLP Regulation 1272/2008.
Hydrocarbons, C16-C20, n-alkanes, isoalkanes, cyclics, <2% aromatics
In a supporting primary dermal irritation study conducted as similar to OECD guideline N°404 in compliance with GLP, six young adult female New Zealand White rabbits were dermally exposed to 0.5 mL of the test material (Hydrocarbons, C16-C20, n-alkanes, isoalkanes, cyclics, <2% aromatics). Test sites were covered with a semi-occlusive dressing for 4 hours. The skin reactions were assessed at 45 minutes, 24, 48 and 72 hours after removal of the dressing. The mean score was calculated across 3 scoring times for all animals at 24, 48 and 72 hours after patch removal. The mean scores over 24, 48 and 72 hours were 0.0 for erythema and for oedema. Based upon the CLP Regulation 1272/2008, Hydrocarbons, C16-C20, n-alkanes, isoalkanes, cyclics, <2% aromatics is not considered as irritating to the rabbit skin (ExxonMobil, 1991a).
In another supporting primary dermal irritation study (ExxonMobil, 1991b), according to OECD guideline 404, young adult New Zealand White rabbits (3 males + 3 females) were dermally exposed to 0.5 mL of the test material (Hydrocarbons, C16-C20, n-alkanes, isoalkanes, cyclics, <2% aromatics). Test sites were covered with a semi-occlusive dressing for 4 hours. Dermal responses were evaluated at 45 min, 24, 48, and 72 hours post-dosing according to the Draize method of scoring. Very slight erythema was observed at 45 min in 3 animals, all symptoms reversed by 24 hours. Edema was not noted in any of the animals. The individual mean score for erythema/eschar and oedema for each of the 3 animals was 0. Based upon the CLP Regulation 1272/2008, Hydrocarbons, C16-C20, n-alkanes, isoalkanes, cyclics, <2% aromatics is not considered as irritating to the rabbit skin.
Ocular irritation
Seven reliable read across studies were available for eye irritation, dealing with the toxicity of Hydrocarbons, C14-C17, n-alkanes, <2% aromatics; Hydroarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics; and Isohexadecae. All studies were conducted similarly or according to OECD guideline 405. All studies show no or slight irritation effects on rabbits' eyes.
Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics
In a key study (TOTAL Solvants, 1998), the eye irritant effect of Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics was investigated according to the OECD Guideline No. 405 (1987) and EEC B.5 method (1992) and in compliance with Good Laboratory Practice. Three female albino rabbits were exposed to 0.1 mL of the test article in the left eye. The eyes were examined and the changes were graded according to a numerical scale 1, 24, 48 and 72 hours after dosing. Minimal conjunctival irritation (redness) was observed in the three rabbits 1 hour after dosing. During the rest of the observation period no abnormalities were observed for two animals while redness (score 1) was still observed up to 48 h in the third animal. Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics is not considered as irritating to the eyes according to the CLP Regulation 1272/2008.
Four supporting read across studies that tested Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics (Carless, 1997; Total Solvants 1996; Anchor Drilling Fluids, 1995a, b) demonstrated that the substance is not considered to be an ocular irritant.
Isohexadecane
In a supporting study (INEOS, 1980), the irritant potential of the substance BP Solvent IH/Isohexadecane was assessed by applying 0.1 mL of the test substance in the conjunctival sac of the left eye of 6 male Himalayan rabbits. After application the animals lid were kept closed for 1 second. The right eye was used as control and received 0.1 mL of physiological NaCl solution. The eyes were examined and the changes were graded according to a numerical scale at 15 min, 1, 24, 48 and 72 hours after dosing. No conjunctival chemosis, corneal and iridal lesion were observed throughout the observation period. Slight redness of the conjunctivae was observed in all animals at 1 hour but only in one animal by the 24 hours after instillation. At 48-hour observation period, no redness was observed in any rabbit. Hence, the mean individual score for redness was 0.33-0.0-0.0. BP Solvent IH/Isohexadecane is not classified as eye irritant according to the CLP Regulation 1272/2008.
Hydrocarbons, C14 -C17, n-alkanes, <2% aromatics
The eye irritant effect of Petrepar-147 was investigated according to the OECD Guideline No. 405 (1981). Three albino rabbits were exposed to 0.1 mL of the test article in one eye. The eyes were examined and the changes were graded according to a numerical scale 1, 24, 48 and 78 hrs and on day 4 and 7 after dosing. The eyes were not rinsed after administration of the test substance. No corneal damage or iridal inflammation was observed. Redness and chemosis were observed in all animals, one hour after instillation. Slight redness was still observed in two animals at 24 hours while slight chemosis was only observed in one rabbit. The eyes of all rabbits were normal 48 hours after instillation. The mean individual scores were 0.33/0.33/0.0 for conjunctival redness and 0.33/0.0/0.0 for chemosis (Petroquimica, 1984).
Justification for classification or non-classification
Skin Irritation:
Based on the available read across data, Icosane does not meet the criteria for classification as a skin irritant under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
Eye Irritation:
Based on the available read across data, Icosane does not meet the criteria for classification as an ocular irritant under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
Respiratory Irritation:
There are no studies that warrant classification as a respiratory irritant under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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