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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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EC number: 278-758-9 | CAS number: 77745-66-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Half-lives range from 4.1 (pH 5) to 20.1 hrs (pH 9) for structurally similar trisodecyl phosphite (TDP) - C10 alkyl phosphite - are provided for tri isotridecyl phosphite - C13 alkyl phosphite. Additional data on other analogs also support the conclusion that this substance rapidly hydrolyzes.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 17 h
- at the temperature of:
- 23 °C
Additional information
It has been well established through a series of modified tests and practical handling experience that this class of alkyl phosphites readily hydrolyses. ECHA actually notes in its REACH Guidance R.11 on PBT assessment that phosphites are a class of substances that are known to hydrolyse in the environment.
Unfortunately, it is actually very hard to test phosphites for their hydrolysis rates in the standard OECD guideline (111) due to the extremely low water solubility of the substances. The registrant sought to place the ECHA requested OECD 111 guideline test on TiTDP with an accredited laboratory but, after much discussion with the laboratory, it was decided that the very low water solubility of TiTDP would render it unsuitable for this test method.
A new comparative study of the hydrolysis of TiTDP and TDP (Carraz 2014) was just conducted to both draw a comparison of the relative rates of hydrolysis between the two phosphites and also to evaluate the rate of hydrolysis in simulated stomach acid (pH=1.2). In this study, it was found that using a co-solvent, 50% acetone in solution, greatly increased the reliability of the results likely because the co-solvent helped make the phosphites available to the aqueous phase allowing hydrolysis to occur. From this study,TiTDP with a t1/2of 0.43 hour hydrolysed more rapidly than TDP with a t1/2of 2.44 hours.
By comparison, the Reimer (2002) hydrolysis test of TDP, using 50% acetonitrile as a co-solvent, gave a half-life of 4.1 hours at pH 5, 17 hours at pH 7 and 20.1 hours at pH 9 at ambient temperature. The shorter half-life at lower pH is to be expected given that the hydrolysis of organophosphites is known to be acid-catalyised.
The results from Carraz (2014) indicate that TiTDP has a similar, perhaps slightly faster, rate of hydrolysis than TDP. As such, these data support the use of the Reimer (2002) results on TDP for TiTDP dossier. The Carraz data also indicate that TiTDP and TDP will behave similarly in the stomach, further supporting the justification for using TDP toxicity data for TiTDP hazard characterization.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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