Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 601-489-9 | CAS number: 1176-81-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Boiling point
Administrative data
Link to relevant study record(s)
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 Aug 2017 - 18 Jan 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- GLP compliance:
- no
- Type of method:
- differential thermal analysis
- Remarks:
- Differential Thermal Analysis (DTA) / Differential Scanning Calorimetry (DSC)
- Remarks on result:
- not determinable
- Between around 180 and 300 °C an endothermic effect could be detected.
- Between approx. 300 – 350 °C and from approx. 350 °C additional endothermic effects were visible.
- A reaction of the test item was indicated by the dark brown melt residue in the crucible after finalization of the test.
- Conclusions:
- No boiling point of Fluocortolon-A-Acetat could be detected. Between around 180 °C and 300 °C an endothermic effect could be detected. Since the endothermic phase could be reproduced in another measurement performed in a closed crucible the endothermic phase resulted from the melting point.
- Executive summary:
A differential thermoanalysis method (DTA/DSC) was used to determine the melting point with test method OECD Guideline 103 'Boiling point' corresponding to AC A.2, "Boiling temperature". The sample was weighed in a crucible made of aluminium, cooled down in a DTA/DSC-system to 20 °C and then heated up to 450 °C (heating rate 5 K/min). In comparison with an inert sample (empty crucible) the temperature difference and the heat effect was recorded. Between around 180 and 300 °C an endothermic effect could be detected. Since the endothermic phase could be reproduced in another measurement performed in a closed crucible the endothermic phase resulted from the melting point. No boiling point could be detected.
Reference
RESULT:
Validity criteria for the measurement of the boiling point:
Target condition according to guideline OECD 103: | Actual condition according to the study: | Validity criteria met: |
The mean of at least two measurements which are in the range of the estimated accuracy (Siwoloboff = +/- 2.0 K) should be reported. | Only one measurement is reported. | No |
The pressure(s) at which the measurements were made shall be reported. The pressure should preferably be close to normal atmospheric pressure. | The atmospheric pressure is stated. | Yes |
Description of key information
A differential thermoanalysis method (DTA/DSC) was used to determine the melting point with test method OECD Guideline 103 'Boiling point' corresponding to AC A.2, "Boiling temperature". Between around 180 and 300 °C an endothermic effect could be detected. Since the endothermic phase could be reproduced in another measurement performed in a closed crucible the endothermic phase resulted from the melting point.No boiling point could be detected.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.