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EC number: 239-594-3 | CAS number: 15546-11-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The following key studies were submitted to fulfil the acute toxicity data requirement:
Oral:
In an acute oral toxicity study equivalent to OECD Guideline No. 401, groups of 10 young adult Sprague-Dawley rats/sex were given a single oral dose of the test item Prosper MSL (96 % Methyl-(Z,Z)-8,8-dibutyl-3,6,10-trioxo-2,7,9-trioxa-8-stannatrideca-4,11-dien-13-oat) in vegetable oil at doses of 0 (vehicle control), 100, 200, 400, 800, and 1600 mg/kg bw and observed for 14 days.
Oral LD50 Females: 419 mg/kg bw (95% C.L. 229.78 to 764.46 mg/kg bw)
Oral LD50 Males: 526 mg/kg bw (95% C.L. 319.59 to 866.74 mg/kg bw)
Treatment related clinical signs were lethargy, motor incoordination, altered faeces consistency, nosebleeding and body weight retardation. There were no treatment related necropsy findings in animals found dead within the observation period or sacrificed at study termination.
Methyl-(Z,Z)-8,8-dibutyl-3,6,10-trioxo-2,7,9-trioxa-8-stannatrideca-4,11-dien-13-oat is of moderate toxicity based on the oral LD50 of 526 and 419 mg/kg bw in male and female rats, respectively.
Dermal:
The acute dermal LD50 of the test material is in the range of 5000 mg/kg bw, as within one week of observation 3/5 males and 2/5 females died after application of this dose, whereas none of the animals treated with 2500 mg/kg bw . The whole treated area of the skin became necrotic and started to slough off seven days after the application of the test material. To avoid unnecessary suffering the experiment was therefore terminated after one instead of two weeks. After treatment a heavy weight loss was also observed.
Inhalation: As the substance is known to be corrosive to the skin, it is considered justified to omit further testing in the interest of animal welfare.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 419 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
Oral:
The Manzo, 1991 study is considered to be the key endpoint for acute oral toxicity as the study seems comparable to the OECD 401 guideline study with acceptable restrictions, however there is no data regarding GLP and has therefore been assigned a Klimisch score of 2. This study is the most recent study available and is also gives the lowest LD50 of the studies and so has been used for classification purposes.
The acute lethal dose (LD50) and 95% confidence limits for dibutyltin methyl maleate were reported as:
Males: 526 (319.59 to 866.74) mg/kg bw
Females: 419 (229.78 to 764.46) mg/kg bw
Supporting information is also available from a summary report for oral toxicity (Davies & Lloyd, 1975). This has been assigned a Klimisch rating of 4 as this is a summary report with very limited information on methods, also there are no deatil regarding purity and it predates GLP.
Result: LD50 1.0 ml/kg (equivalent to 1380 mg/kg)
Dermal:
The Sarasin, 1981 study is considered to be the key endpoint for acute dermal toxicity as the study seems comparable to guideline study with acceptable restrictions, however there is no data regarding purity and GLP and has therefore been assigned a Klimisch score of 2.
Inhalation: As the substance is known to be corrosive to the skin, it is considered justified to omit further testing in the interest of animal welfare.
Justification for classification or non-classification
Oral:
According to the criteria set out in Directive 67/548/EEC, the test material is classified with R22; Harmful if swallowed, and as Acute Category 4; H302: Harmful if swallowed, according to Regulation (EC) No 1272/2008.
Dermal:
The key parameter chosen for acute toxicity for the dermal route is greater than the criteria set out in Directive 67/548/EEC and also Regulation (EC) No 1272/2008, therefore classification for acute dermal toxicity is not considered to be necessary.
Inhalation: Further testing for this endpoint is considered uneccessary, as the substance is classified as corrosive.
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