Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-733-6 | CAS number: 110-05-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21-Apr-2010 to 23-Sep-2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of Certificate: November 12, 2008
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Before and after incubation at 50 °C, 100 µL aliquots of the test solutions at each pH value were taken through a septum in order to avoid the contact with air and diluted in 10.5 mL of dimethyl sulfoxide in a headspace vial. The samples were analyzed by measuring the MS signal of di-tert-butyl peroxide (CAS# 110-05-4) after GC separation of the injected sample solution.
- Buffers:
- - Buffer Solution pH 4.0
- Buffer Solution pH 7.0
- Buffer Solution pH 9.0
The buffer solutions were autoclaved prior to first use.
Preparation of Buffer Solution pH 7.0 for Sample Preparation
387.6 mL of buffer pH 7.0 were diluted up to 1 L with water and adjusted to pH 7.0 with phosphoric acid. - Estimation method (if used):
- Not used.
- Duration:
- 120 h
- pH:
- 4
- Initial conc. measured:
- 34.77 mg/L
- Duration:
- 120 h
- pH:
- 7
- Initial conc. measured:
- 34.25 mg/L
- Duration:
- 120 h
- pH:
- 9
- Initial conc. measured:
- 77.92 mg/L
- Number of replicates:
- At least duplicate sample solutions were incubated.
- Positive controls:
- not specified
- Negative controls:
- not specified
- Statistical methods:
- Not specified.
- Transformation products:
- not specified
- % Recovery:
- 100.2
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 110
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 92.6
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Type:
- other: after 5 days at 50 °C, <10% were degraded, therefore the half-life time is >1 year
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Type:
- other: after 5 days at 50 °C, <10% were degraded, therefore the half-life time is >1 year
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Type:
- other: after 5 days at 50 °C, <10% were degraded, therefore the half-life time is >1 year
- Other kinetic parameters:
- None.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The degradation of di-tert-butyl peroxide (CAS# 110-05-4) was less than 10% after 5 days at 50 °C and pH 4, 7 and 9. di-tert-butyl peroxide (CAS# 110-05-4) was considered to be hydrolytically stable, and no further testing was necessary.
- Executive summary:
The purpose of this study was to determine the hydrolysis behavior of di-tert-butyl peroxide (CAS# 110-05-4) in aqueous buffered solutions adjusted to pH 4.0, pH 7.0 and pH 9.0.
Hydrolysis is one of the most common reactions controlling abiotic degradation in the environment. This reaction is particularly relevant for substances with low biodegradability.
The hydrolysis determination of di-tert-butyl peroxide (CAS# 110-05-4) at different pH values was based on the OECD Guideline No. 111, “Hydrolysis as a Function of pH"; adoptedApril 13, 2004and the Council Regulation (EC) 440/2008 C.7.
The hydrolysis determination of di-tert-butyl peroxide (CAS# 110-05-4) at different pH values was based on the OECD Guideline No. 111, “Hydrolysis as a Function of pH”; adoptedApril 13, 2004.
The results of the tests at pH 4.0, pH 7.0 and pH 9.0 showed no significant degradation of di-tert-butyl peroxide (CAS# 110-05-4) at 50 °C. The degradation of di-tert-butyl peroxide (CAS# 110-05-4) was less than 10% after 5 days. These results are summarized in the table below.
pH
Hydrolysis after 5 days, 50 °C
[%]4.0
< 10
7.0
< 10
9.0
< 10
According to the OECD Guideline No. 111 it can be concluded, that the estimated half-life time is higher than one year under representative environmental conditions (25 °C). Therefore, di-tert-butyl peroxide (CAS# 110-05-4) is considered to be hydrolytically stable, and no further testing was necessary.
Reference
The results of the individual measurements are summarized in the attached table. The tabulated values represent rounded results obtained by calculation used the exact raw data.
A typical chromatogram of a standard solution is given in the attached Figure 1. Typical chromatograms of the test solutions after an incubation time of 5 days are given in the attached Figure 2 to Figure 4. The calibration curve of di-tert-butyl peroxide (CAS# 110-05-4) is shown in attached Figure 5. The calibration data are given in Table 2. The r2fit was 0.9993 (optimum 1.0000). This reflects the suitability of the GC-MS system within the range of 0.034 µg/mL to 1.100 µg/mL of test item.
The results of the tests at pH 4.0, pH 7.0 and pH 9.0 showed no significant degradation of di-tert-butyl peroxide (CAS# 110-05-4) at 50 °C.
Table 1 Results of the Preliminary Test of di-tert-butyl peroxide (CAS# 110-05-4)
|
Initial concen-tration measured |
Mean Concen-tration |
Concen-tration measured after 2.4 h incubation |
Mean Concen-tration |
Recovery |
Concen-tration measured after 5 days incubation |
Mean Concen-tration |
Recovery |
|
[µg/mL] |
[µg/mL] |
[µg/mL] |
[µg/mL] |
[%] |
[µg/mL] |
[µg/mL] |
[%] |
pH 4.0 |
|
34.77 |
|
36.78 |
105.7 |
38.77 |
34.84 |
100.2 |
|
|
42.44 |
||||||
27.88 |
|
25.52 |
||||||
34.85 |
36.80 |
24.81 |
||||||
38.47 |
36.71 |
49.54 |
||||||
37.9 |
|
48.18 |
||||||
|
|
26.15 |
||||||
|
|
23.31 |
||||||
pH 7.0 |
|
34.25 |
|
32.13 |
93.81 |
41.56 |
37.66 |
110.0 |
33.54 |
|
28.70 |
||||||
34.94 |
32.90 |
37.80 |
||||||
34.28 |
31.36 |
44.25 |
||||||
|
|
34.21 |
||||||
|
|
39.42 |
||||||
pH 9.0 |
|
77.92 |
|
81.64 |
104.8 |
99.50 |
72.15 |
92.6 |
|
|
92.88 |
||||||
76.20 |
81.63 |
92.03 |
||||||
79.64 |
81.66 |
27.63 |
||||||
|
|
71.56 |
||||||
|
|
49.31 |
Description of key information
Half-life of the substance at 25°C was predictd as greater than 1 year at pH = 4, pH = 7 and pH = 9.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
Hydrolysis of the substance was assessed following a reliable GLP study according to the OECD 111 guidelines (Elsner, 2010). In buffer solutions at pH = 4.0, pH = 7.0 and pH = 9.0 covering the extremes and typical environmental pHs, the substance at an initial concentration of 0.1 mg/L was monitored at 2.4h and 120h by GC-MS at 50°C in a preliminary test. Less than 10% of the substance was degraded after 120h. Following the guidelines, the study was terminated since no abiotic degradation was observed at this stage of the test. It was finally concluded that the half-life of the substance at 25°C was over 1 year at pH = 4, pH = 7 and pH = 9.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)