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EC number: 236-031-3 | CAS number: 13106-76-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin sensitization
From the British medical journal 15 November 1975, patch test was performed on 50 patient using Al-test strips to the pads of which were applied the metal allergens. Ammonium molybdate was placed on back and held in place with hypoallergic tape. Patch was kept for 3 days and again the test site was examined on seventh day. No sensitivity was observed for ammonium molybdate, therefore ammonium molybdate (13106-76-8) was determined to be non-sensitizing to human after exposure.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal.
- Justification for type of information:
- Data is from peer reviewed journal.
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To observed the effect of ammonium molybdate which was used in patch test to 50 patient using Al-test strips.
- GLP compliance:
- not specified
- Type of study:
- patch test
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): ammonium molybdate(VI)
- Molecular formula: MoO4.2H4N
- Molecular weight: 196.0132 g/mol
- Smiles notation: [Mo](=O)(=O)([O-])[O-].[NH4+].[NH4+]
- InChl: 1S/Mo.2H3N.4O/h;2*1H3;;;;/q;;;;;2*-1/p+2
- Substance type: Inorganic
- Physical state: Solid - Species:
- other: Human
- Strain:
- other: not applicable
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available
- Route:
- epicutaneous, open
- Vehicle:
- not specified
- Concentration / amount:
- 1%
- Day(s)/duration:
- 3 days
- No. of animals per dose:
- 50 patient
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 1
- Exposure period: 3 days
- Test groups: 50 patient
- Site: on the back and held in place with hypoallergic tape
- Frequency of applications: 1
- Duration: 3 days
- Concentrations: 1% - Challenge controls:
- No data available
- Positive control substance(s):
- not specified
- Reading:
- other: induction
- Group:
- test chemical
- Dose level:
- 1% of ammonium molybdate
- Total no. in group:
- 50
- Clinical observations:
- No reaction was observed
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- other: Not sensitizing
- Conclusions:
- The ammonium molybdate (13106-76-8) was determined to be non-sensitizing to human after exposure.
- Executive summary:
Patch test was performed on 50 patient using Al-test strips to the pads of which were applied the metal allergens. Ammonium molybdate was placed on back and held in place with hypoallergic tape. Patch was kept for 3 days and again the test site was examined on seventh day.
No sensitivity was observed for ammonium molybdate, therefore ammonium molybdate (13106-76-8) was considered to be non-sensitizing to human after exposure.
Reference
score used for observation
· + erythema
· ++ vesicular rash confined to area of patch
- +++- extensive eczematous reaction beyond area of patch
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In different studies, ammonium molybdate (13106-76-8) has been investigated for potential of skin sensitization to a greater or lesser extent. The studies are based on in vivo experiments in human for target chemical ammonium molybdate (13106-76-8).
From the British medical journal 15 November 1975, patch test was performed on 50 patient using Al-test strips to the pads of which were applied the metal allergens. Ammonium molybdate was placed on back and held in place with hypoallergic tape. Patch was kept for 3 days and again the test site was examined on seventh day. No sensitivity was observed for ammonium molybdate, therefore ammonium molybdate (13106-76-8) was determined to be non-sensitizing to human after exposure.
Supported to the above key study skin sensitization test was performed in humans from MAK Collection for Occupational Health and Safety, 2012. The ammonium molybdate was applied to 63 patients during dental prostheses. Concentration of chemical was 1% after treatment it was observed that the ammonium molybdate (13106-76-8) was determined to be not sensitizing to human.
From the same reference, ammonium molybdate was applied to 50 patients for joint prostheses. Concentration of chemical was 1% after treatment it was observed that the ammonium molybdate (13106-76-8) was found to be not sensitizing to human.
Ammonium molybdate was applied to 128 patients for hip prostheses from the above same reference. Concentration of chemical was 1% of ammonium molybdate and after treatment it was observed that the ammonium molybdate (13106-76-8) was determined to be sensitizing to human.
Thus based on key and supporting data, it can be considered that ammonium molybdate (13106-76-8) was not a skin sensitizer supported by the majority of the above studies. Thus comparing the above annotations with the criteria of CLP regulation, ammonium molybdate (13106-76-8) can be considered as not classified for skin sensitization.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on key and supporting data, it can be considered that ammonium molybdate (13106-76-8) was not a skin sensitizer supported by the majority of the above studies. Thus comparing the above annotations with the criteria of CLP regulation, ammonium molybdate (13106-76-8) can be considered as not classified for skin sensitization.
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