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Diss Factsheets
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EC number: 200-842-0 | CAS number: 75-12-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline studies with acceptable restrictions. Extented exposure period; short observation period. Extrapolation of the effects to 4-hour exposure conditions is, however, possible.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: BASF; internal guideline
- Principles of method if other than guideline:
- 2 mL of undiluted test substance was applied to the intact skin of two rabbits under occlusive dressing for 20 hours. Skin reactions were scored on days 1, 2, 3, and 5 after application similar to the scores contained in teh OECD guideline No. 404.
- GLP compliance:
- no
- Remarks:
- Pre-guideline, pre-GLP study
Test material
- Reference substance name:
- Formamide
- EC Number:
- 200-842-0
- EC Name:
- Formamide
- Cas Number:
- 75-12-7
- Molecular formula:
- CH3NO
- IUPAC Name:
- formamide
- Details on test material:
- Formamide, degree of purity not reported.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Vehicle:
- other: no vehicle
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 20 hour(s)
- Observation period:
- 5 days
- Number of animals:
- 2
Results and discussion
In vivo
Results
- Remarks on result:
- other: Formamide (shaved back skin of 2 rabbits, 20 h under an occlusive dressing). Result: marked erythema at 24 h and slight erythema at 24 and 48 h after initiation of treatment. Erythema was absent on day 5, and scaling was seen at the treated sites.
Any other information on results incl. tables
The ear showed no irritation at any reading.
Reactions of the back skin were as
follows:
- 1, 5, and 15 minute exposures: no skin reactions
- 20 hour exposure:
slight to moderate erythema
in one rabbit, and very slight (questionable) erythema in
the other rabbit. At the 8-day reading, slight scaling was
observed in both rabbits at the treated site.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
Formamide, applied to the shaved back skin of 2 rabbits for 20 hours under an occlusive dressing, caused marked erythema at 24 hours and slight erythema at 24 and 48 hours after initiation of treatment. Erythema was absent on day 5, and scaling was seen at the treated sites.
A 20-hour occlusive exposure exceeds by far current test guideline exposure conditions and represents very severe conditions. Only very slight signs of irritation were seen under these conditions. Therefore, the type and severity of the effects suggest that formamide is not irritating when these results are extrapolated to a 4 -hour exposure period.
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