Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-618-5 | CAS number: 85-60-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 May 2012 to 06 July 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed in accordance with OECD & EU test guidance in compliance with GLP.
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- other: soil-adsorption-reference data
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not specified - Radiolabelling:
- no
- Details on study design: HPLC method:
- Instrument: Alliance Separation Module 2695 (Waters, Milford, MA, USA)
Detector: Dual λ Absorbance Detector 2487 (Waters)
Column: Hypersil BDS-CN, 150 mm x 4.6 mm i.d., dp = 5 μm (Thermo Fisher Scientific, Waltham, MA, USA)
Column temperature: 35°C ± 1°C
Mobile phase: 55/45 (v/v) methanol/water
Flow: 1 ml/min
Injection volume: 10 μl
UV detection: 210 nm
Preparation of the solutions
Solution of the unretained compound: A 5.61 g/l stock solution of formamide (99.8%, [75-12-7], Acros Organics, Geel, Belgium) in methanol was used. The stock solution was diluted to obtain an end solution of 55/45 (v/v) methanol/water.
The formamide blank solution was 55/45 (v/v) methanol/water.
Reference substance solutions: Stock solutions of the reference substances at concentrations of approximately 1 g/l in methanol were used. The stock solutions were diluted to obtain an end solution of 55/45 (v/v) methanol/water.
The blank solution for the mixture of reference substances was 55/45 (v/v) methanol/water.
Test solution: A 1004 mg/l stock solution of the test substance was prepared in methanol. The stock solution was diluted to obtain an end solution of 55/45 (v/v) methanol/water. The final concentration of the test substance solution was 10.0 mg/l.
The test substance blank solution was 55/45 (v/v) methanol/water.
Injections: The reference substance and test substance solutions were injected in duplicate. Blank solutions were analysed by single injection. - Type:
- log Koc
- Value:
- 5.48
- Details on results (HPLC method):
- In the chromatogram of the test solution, one test substance peak was observed.
The results of the HPLC method show the calibration curve of the log k’ of the reference substances as function of log Koc. The equation of the regression line was:
log k’ = 0.281 x log Koc – 1.17 (r = 0.98, n = 16). - Validity criteria fulfilled:
- yes
- Conclusions:
- The Koc and log Koc value of the test substance and impurities at neutral pH was:
Koc : 3.0 x 105
log Koc: 5.48 - Executive summary:
Study performed in accordance with European Community (EC), EC no. 440/2008, Part C: Methods for the Determination of Ecotoxicity, Guideline C.19: “Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC)”, OECD Guideline for the Testing of Chemicals no. 121: "Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC)” and in compliance with the Principles of Good Laboratory Practice (GLP).
The HPLC method using soil-adsorption-reference data was applied for the determination of the adsorption coefficient (Koc) of 6,6’-di-tert-butyl-4,4’-butylidenedi-m-cresol.
The Kocand log Kocvalue of the test substance and impurities at neutral pH was:
Koc: 3.0 x 105
log Koc: 5.48
Reference
Kocof the test substance
Substance |
tr1 [min] |
tr2 [min] |
Mean tr(n=2) |
Log Koc |
Koc |
Formamide (t0) |
1.980 |
1.981 |
1.981 |
|
|
Acetanilide |
2.223 |
2.221 |
|
1.26 |
|
Atrazine |
2.400 |
2.397 |
|
1.81 |
|
Monuron |
2.446 |
2.448 |
|
1.99 |
|
2,5-Dichloroaniline |
2.702 |
2.704 |
|
2.55 |
|
Benzoic acid phenylester |
2.943 |
2.937 |
|
2.87 |
|
Fenthion |
3.662 |
3.669 |
|
3.31 |
|
Phenanthrene |
3.775 |
3.764 |
|
4.09 |
|
4,4’-DDT |
6.208 |
6.220 |
|
5.63 |
|
Test substance |
6.6351 |
6.6151 |
6.625 |
5.48 |
3.0 x 105 |
1Obtained by extrapolation of the calibration curve.
Description of key information
Key value determined by HPLC estimation method in compliance with OECD & EU test guidance.
Koc : 3.0 E+5
log Koc: 5.48
Key value for chemical safety assessment
- Koc at 20 °C:
- 300 000
Additional information
[LogKoc: 5.48]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)