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EC number: 221-904-3 | CAS number: 3275-24-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Titanium tetrakic(dimethylammonium) is an organometalic compound. It can only be handled in air-free environments. It is a flammable liquid and extremely unstable (see also chapter 1.2 or 13). Within seconds, it reacts violently in contact with moisture or water. The decomposition products are dimethylamine and titanium oxide. Dimethylamine is a highly flammable, water-soluble gas. Aqueous solutions of dimethylamine were tested in an in vitro gene mutation assay. Dimethylamine showed no mutagenic potential, both with and without metabolic activation in a study according to OECD TG 471.
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
- Specific details on test material used for the study:
- supplier: Eastman
purity: vendor purity no further information given - Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Details on mammalian cell type (if applicable):
- not applicable
- Additional strain / cell type characteristics:
- not applicable
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 fractions of Acrolor 1254-induced male Sprague-Dawley rat livers and male Syrian hamster livers were prepared. The S9 mixes were prepared immediately prior to use and contained 10% S9
- Test concentrations with justification for top dose:
- first test: 0; 33; 100; 333; 1000; 2000; 3333; 4500 µg/plate
second test: 0; 100; 333; 1000; 2000; 3333; 4000 µg/plate - Vehicle / solvent:
- distilled water
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- sodium azide
- other: 4-nitro-o-phenylenediamine: without metabolic activation, strain TA98; 2-aminoanthracene: with metabolic activation, all strains tested
- Details on test system and experimental conditions:
- prior to the main test a toxicity assay was carried out with strain TA 100 to determine the appropriate dose range
seven doses were tested in triplicate, experiment was repeated one week after the initial trial - Evaluation criteria:
- A chemical was judged to be mutagenic (+) or weakly mutagenic (+W) if it produce a reproducible, doese related increase in his+ over the corresponding solvent control in replicate trials. A chemical was considered questionable if a reproducible increase in his+revertants did not meet the criteria of either a "+" or"+W" or if only a single doses produced an increase in his+ revertants in repeat trials
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- True negative controls validity:
- not examined
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium TA 1537
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- True negative controls validity:
- not examined
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- True negative controls validity:
- not examined
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- True negative controls validity:
- not examined
- Positive controls validity:
- valid
- Remarks on result:
- other: not mutagenic
- Executive summary:
Dimethylamine did not show any mutagenic potential both with and without metabolic activation in an in vitro bacterial gene mutation study according to OECD TG 471.
- Endpoint:
- in vitro gene mutation study in bacteria
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Justification for type of information:
- Titanium tetrakic(dimethylammonium) is an organometalic compound. It can only be handled air-free. It is a flammable liquid and very unstable (see also chapter 1.2 or 13). Within seconds it reacts violently in contact with moisture or water. The decomposition products are dimethylamine and titanium oxide. Dimethylamine is a highly flammable gas but water soluble. Aqueous solutions of dimethylamine were tested for in vitro gene mutation.
Referenceopen allclose all
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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