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Diss Factsheets
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EC number: 270-192-0 | CAS number: 68412-48-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 February 2018 to 24 February 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- Commission Regulation (EC) No 440/2008 of 30 May 2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), Part A, A.6 Water Solubility
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- Organisation for Economic Co-operation and Development (OECD), OECD Guidelines for Testing of Chemicals, Guideline No. 105, "Water Solubility", adopted July 27, 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- No further details specified in the study report.
- Key result
- Water solubility:
- < 5.75 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- > 5.37 - < 5.69
- Details on results:
- The pH of the samples varied in the range of 5.37 – 5.69, the pH of control water samples varied in the range of 5.36 – 5.59.
Samples were analysed with the above NPOC method. The control samples were used for correction of the measured values of samples.
Based on the validation, the limit of quantification of NPOC method is 5 mg carbon/L. Assuming that the components of the test item are equally soluble in water, a theoretical limit of quantification can be given as 5.76 mg/L for the test item, as it is 86.87% carbon - Conclusions:
- The carbon content of the soluble fraction of this UVCB substance was below the quantification limit (5 mg carbon/L) in each case. Considering, that the carbon content of test item is 86.87% based on the results of the elemental analysis, the water solubility of AMINOX® can be considered less as than 5.76 mg/L at 20°C.
- Executive summary:
The purpose of this study was to determine the water solubility of AMINOX®, which is specified by the saturation mass concentration of the test item in water preferably at 20 ± 0.5 °C.
Although, as the expected water solubility is below 10-2 g/L, the flask method was applied because the column method is not suited to the NPOC analytical method.
Study performed in accordance with the following guidelines:
-Commission Regulation (EC) No 440/2008 of 30 May 2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), Part A, A.6 Water Solubility
-Organisation for Economic Co-operation and Development (OECD), OECD Guidelines for Testing of Chemicals, Guideline No. 105, "Water Solubility", adopted July 27, 1995
Considering, that the test item is an UVCB, without no signal chemical marker, the quantification of water solubility was made by the carbon content of the soluble fraction of test item was measured using a NPOC method. The carbon content of the soluble fraction of this UVCB substance was below the quantification limit (5 mg carbon/L) in each case. Considering, that the carbon content of test item is 86.87% based on the results of the elemental analysis, the water solubility of AMINOX® can be considered less than 5.75 mg/L at 20 °C, based on a theoretical calculation.
Reference
Results of the determination of the test item concentrations
Measured carbon content after 1 day (mg/L) |
pH |
Measured carbon content after 2 day (mg/L) |
pH |
Measured carbon content after 3 day (mg/L) |
pH |
Solubility of the test item (mg/L) |
<LOQ |
5.41 |
<LOQ |
5.61 |
<LOQ |
5.37 |
<LOQ |
<LOQ |
5.46 |
<LOQ |
5.48 |
<LOQ |
5.41 |
|
<LOQ |
5.39 |
<LOQ |
5.69 |
<LOQ |
5.54 |
Description of key information
The water solubility of AMINOX® can be considered less than 5.75 mg/L at 20 °C, based on a theoretical calculation.
Key value for chemical safety assessment
- Water solubility:
- 5.75 mg/L
- at the temperature of:
- 20 °C
Additional information
The purpose of this study was to determine the water solubility of AMINOX®, which is specified by the saturation mass concentration of the test item in water preferably at 2 0± 0.5 °C.
Although, as the expected water solubility is below 10-2 g/L, the flask method was applied because the column method is not suited to the NPOC analytical method.
Considering, that the test item is an UVCB, without no signal chemical marker, the quantification of water solubility was made by the carbon content of the soluble fraction of test item was measured using a NPOC method. The carbon content of the soluble fraction of this UVCB substance was below the quantification limit (5 mg carbon/L) in each case. Considering, that the carbon content of test item is 86.87% based on the results of the elemental analysis, the water solubility of AMINOX® can be considered less than 5.75 mg/L at 20 °C, based on a theoretical calculation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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