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EC number: 270-560-0 | CAS number: 68443-84-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with Regulation (EC) No. 1907/2006, Annex X, Column 2, 9.4 further studies on the effects on terrestrial organisms does not have to be conducted since the chemical safety assessment indicates that there is no need.
Key value for chemical safety assessment
Additional information
A chronic earthworm reproduction test according to OECD 222 is available for DiPE triisononanoate triethylhexanoate (CAS No. 68443-84-5). Mortality or a decrease in body weight of the adult earthworms was not observed. Thus a NOEC ≥ 1000 mg/kg soil based on the reproduction rate was determined. The result shows that adverse effects of the test substance to terrestrial organisms are highly unlikely. This assumption is further supported by information on the metabolism and aquatic ecotoxicity as given in more detail below.
Aquatic ecotoxicity data
Acute and chronic aquatic toxicity tests of the substance and its read across substances (CAS No. 647028-25-9, Dipentaerythritol ester of nC5/iC9 acids; CAS No. 84418-63-3, Isononanoic acid, mixed esters with dipentaerythritol, heptanoic acid and pentaerythritol) to fish, invertebrates, algae and microorganisms showed no adverse effects occurred in the range of the water solubility of the substance (< 0.05 mg/L measured in aqua dest). The absence of chronic or long-term toxicological effects in aquatic organisms up to the substance solubility limit, can, as ECHAs Guidance R.7c states, can be used as part of a Weight of Evidence argument to modify/waive the data requirements of Annex IX and X. There is a chronic test on aquatic invertebrates available for this substance resulting in a LC50 (21d) well above the limit of water solubility. This result is also supported by algal toxicity data where no toxicity was observed within the water solubility, either. Therefore, it is assumed that due to the lack of chronic aquatic toxicity, long term tests on terrestrial organisms will not result in a different outcome.
Metabolisms/Bioaccumulation
After uptake by organisms, biotransformation of the substance by carboxylesterases into 2-Ethylhexanoic acid, Isononanoic acid and the corresponding alcohol is expected. However, the molecular weight range of 1053 g/mol and the high octanol/water partition coefficient of > 10 in combination with the low water solubility, indicates a low absorption and correspondently slower hydrolysis rate for this substance. All three metabolites are not of concern for the environment. REACh registration dossiers of 2-Ethylhexanoic acid, Isononanoic acid and Dipentaerythritol are available and can be publicly viewed on the ECHA webpage (http://echa.europa.eu/web/guest/information-on-chemicals/registered-substances). QSAR estimations using BCFBAF v3.0 support the expected low bioconcentration with BCF/BAF values of <1 L/kg for this substance.
Conclusion
After uptake by soil species, biotransformation of the substance by carboxylesterases into Dipentaerythritol, 2-ethylhexanoic acid and Isononanoic acid is expected. The supporting BCF/BAF values estimated with the BCFBAF v3.01 program, Arnot-Gobas model including biotransformation, also indicate that this substance will not be bioaccumulative (all below 1 L/kg). Furthermore, aquatic toxicity data show that no effects occur up to the limit of water solubility, even in a chronic Daphnia reproduction test (OECD 211). In addition an OECD 222 reproduction test to earthworm, revealed that no effects occur up to the highest test substance concentration (NOEC >= 1000 mg/kg). Therefore, in accordance with Regulation (EC) No. 1907/2006, Annex X, Column 2, 9.4 further studies on the effects on terrestrial organisms does not have to be conducted since the chemical safety assessment indicates that there is no need.
A detailed reference list is provided in the technical dossier (see IUCLID, section 13) and within CSR.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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