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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 225-863-2 | CAS number: 5124-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Phototransformation in air
Administrative data
Link to relevant study record(s)
- Endpoint:
- phototransformation in air
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Principles of method if other than guideline:
- Calculated with AOP Program v1.92 of EPI-Suite Software. The Atmospheric Oxidation Program (AOPWIN) estimates the rate constant for the atmospheric, gas-phase reaction between photochemically produced hydroxyl radicals and organic chemicals. The rate constants are then used to calculate atmospheric half-lives for organic compounds based upon average atmospheric concentrations of hydroxyl radicals and ozone.
- GLP compliance:
- no
- Estimation method (if used):
- PHOTOCHEMICAL REACTION WITH OH RADICALS
- sensitiser for indirect photolysis: OH radicals
- Concentration of OH radicals: 0.5 E6 OH/cm³, 24 h/d
- DT50:
- 15 h
- Test condition:
- 25 °C
- Executive summary:
The photodegradation of 4,4-methylenedicyclohexyl diisocyanate was estimated with AOPWIN v. 1.92. Based on a
OH radical concentration of 0.5 E06 OH/cm³, the atmospheric oxidation rate constant of "substance" (CAS:5124 -30 -1) is 26 * 10-12cm3/(molecule *s) and its atmospheric half-life is 15 hrs (Currenta, 2009).
Reference
A 24-hour day and an OH radical concentration of 0.5 E06 OH/cm³ are assumed for the calculation. |
Description of key information
There are no experimental data on the stability of 4,4’-methylenedicyclohexyl diisocyanate in the atmosphere.
A half-life of about 15 hours is estimated due to reaction with photochemically produced hydroxyl radicals, considering a mean OH concentration of 0.5 x 106 OH radicals/cm³ as a 24 h-average (Currenta, 2009a). However, the AOPWIN program used for this estimate does not take into account that 4,4’-methylene- dicyclohexyl diisocyanate is sensitive to hydrolysis e.g. in aerosols with aquatic phases.
The photodegradation of the hydrolysis product of 4,4’-methylenedicyclohexyl diisocyanate was estimated with AOPWIN v. 1.92. The atmospheric oxidation rate constant of the hydrolysis product of 4,4’-methylenedicyclohexyl diisocyanate (CAS:1761 -71 -3) is 117 * 10-12cm3/(molecule *s) and its atmospheric half-life is about 3 hrs at a mean OH concentration of 0.5 x 106 OH radicals/cm³ (Currenta, 2009b).
Key value for chemical safety assessment
- Half-life in air:
- 15 h
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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