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Diss Factsheets
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EC number: 208-591-9 | CAS number: 534-17-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Cs2CO3 is not acutely toxic via the oral route as an LD50 was determined to be above 2000 mg/kg bw based on WoE assessment including the source substance CsCl. An LD50 of 2333 mg/kg bw with the target substance is used as key value.
Cs2CO3 is not acutely toxic via the dermal route as LD50 dermal > 2000 mg/kg bw based on WoE assessment of read-across and target substance data.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- HYPOTHESIS FOR THE ANALOGUE APPROACH
Cesium carbonate completely dissociates in water forming cesium cation and the corresponding carbonate anion. Thus, cesium salts with different anion moieties were found to be suitable candidates for read-across. (Eco)toxicological properties were extrapolated to different endpoints by using the lowest effect concentration.
For further information, please refer to the read-across justification in IUCLID section 13. - Reason / purpose for cross-reference:
- read-across source
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 974 mg/kg bw
- Based on:
- other: calculated for Cs
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 420 mg/kg bw
- Based on:
- other: calculated for Cs2CO3
- Remarks on result:
- other:
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- according to guideline
- Guideline:
- other: no data
- GLP compliance:
- not specified
- Test type:
- other: no data
- Species:
- mouse
- Strain:
- other: Swiss albino mice (Mus musculus)
- Sex:
- female
- Route of administration:
- other: oral
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 500 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 420 mg/kg bw
- Based on:
- other: calculated as cesium carbonate
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral LD50 value of cesium chloride in mice was determined to be 2600 mg/kg bw. Calculated as cesium carbonate the LD50 value is 2420 mg/kg bw.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- according to guideline
- Guideline:
- other: no data
- GLP compliance:
- not specified
- Test type:
- other: no data
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- other: oral
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 333 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- Toxicity Category V
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of cesium carbonate in rats was determined to be 2333 mg/kg bw.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 333 mg/kg bw
- Quality of whole database:
- Three literature values are used in a weight of evidence approach.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- HYPOTHESIS FOR THE ANALOGUE APPROACH
Cesium carbonate completely dissociates in water forming cesium cation and the corresponding carbonate anion. Thus, cesium salts with different anion moieties were found to be suitable candidates for read-across. (Eco)toxicological properties were extrapolated to different endpoints by using the lowest effect concentration.
For further information, please refer to the read-across justification in IUCLID section 13. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- other: Cs2CO3
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 2 000 mg/kg bw
Additional information
Acute oral toxicity
According to the review article (Bibra toxicology advice & consulting, 2000) on the toxicity profile of cesium compounds an LD50 value of 2333 mg/kg bw was determined for cesium carbonate when administered to rats orally. Similar LD50 values were determined for mice that were treated with cesium carbonate and cesium chloride. LD50 values were 2420 and 2170 mg/kg bw, respectively.
Acute dermal toxicity
An acute dermal toxicity study with cesium carbonate is not available. Consequently, data from the source substance CsNO3 was used. CsNO3 was tested up to the limit concentration of 2000 mg/kg bw. No test item related toxic effects or other changes were observed. It is assumed that Cs2CO3 has an LD50 above 2000 mg/kg bw.
The assumption of low acute dermal toxicity for the target substance is supported by the fact that bioavailability of the ions formed will be very low via the skin.
Carbonate has further been described in brief profiles published by Eurometaux on systemic toxicological effects of common counterions in metal substances. Carbonates are omnipresent in the environment including human diet and are involved in essential physiological functions. Carbonates pose no toxicological risk for humans and are therefore not contributing to the overall toxicity of the cesium salt.
The low acute oral toxicity of the target substance further concludes the above assumptions.
Further information can be found in the read across justification in IUCLID section 13.
Justification for classification or non-classification
Based on the data for the acute oral toxicity endpoint, the LD50 for the test item was found to be >2000 mg/kg bw. Therefore, the test item is not classified according to Regulation (EC) No 1272/2008 (CLP/GHS) for acute oral toxicity.
Baed on the results of an acute dermal toxicity study with the source substance and the intrinsic properties of the test item, it is not classified according to Regulation (EC) No 1272/2008 (CLP/GHS) for acute dermal toxicity.
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