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EC number: 265-151-9 | CAS number: 64742-49-0 A complex combination of hydrocarbons obtained by treating a petroleum fraction with hydrogen in the presence of a catalyst. It consists of hydrocarbons having carbon numbers predominantly in the range of C4 through C11 and boiling in the range of approximately minus 20°C to 190°C (-4°F to 374°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
The acute toxicity of members of the low boiling point naphtha category has been investigated in a large number of animal studies (44 oral/dermal and 38 inhalation). Around 20 individual CAS RNs from the category have been tested, and the acute toxicity can be summarised as follows:
Acute toxicity – Oral LD50 > 5000 mg/kg (OECD TG 401)
Acute toxicity – Dermal LD50 > 2000 mg/kg (OECD TG 402 under occlusive conditions)
Acute toxicity – Inhalation LC50 > 5610 mg/m3 (OECD TG 403)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- One of 43 acute toxicity studies carried out on members of the Low boiling point naphtha category
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 5 610 mg/m³ air
- Quality of whole database:
- one of 39 studies on the acute inhalation toxicity of low boiling point naphthas
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- one of 44 well conducted studies on lo boiling point naphthas
Additional information
The acute toxicity of members of the low boiling point naphtha category has been investigated in a large number of animal studies (44 oral/dermal and 38 inhalation). Around 20 individual CAS RNs from the category have been tested and show similar result, summarised as follows:
Acute toxicity – Oral LD50 > 5000 mg/kg (OECD TG 401)
Acute toxicity – Dermal LD50 > 2000 mg/kg (OECD TG 402 under occlusive conditions)
Acute toxicity – Inhalation LC50 > 5610 mg/m3 (OECD TG 403)
Human evidence also indicates that gasoline has very low acute oral, dermal or inhalation toxicity. However, it can produce severe injury if taken into the lung as a liquid, and there may be profound central nervous system depression following prolonged exposure to high levels of vapor. Laboratory animals respond similarly to humans. Neither gasoline itself, nor any of the naphtha blending stocks produces acute oral, dermal or inhalation toxicity under conditions defined by regulatory testing protocols.
Justification for selection of acute toxicity – oral endpoint
one of a large number of studies showing LD50 > 5000 mg/kg
Justification for selection of acute toxicity – inhalation endpoint
one of a large number of acute studies by the inhalation route
Justification for selection of acute toxicity – dermal endpoint
one of a number of studies showing acute dermal LD50 > 2000 mgkg
Justification for classification or non-classification
Although most of these studies were conducted many years ago, they were generally, conducted in accordance with regulatory guidelines good laboratory practice recommendations. The data are this considered adequate for regulatory purposes and no additional testing is warranted.
Acute inhalation toxicity:
It is acknowledged that the Key study was only tested up to a targeted nominal concentration of 5 mg/L (at the time the study was conducted, the recognised limit value). This study, along with the weight of evidence from supporting studies, show no mortality at this dose level. Additionally, there are two inhalation repeated tox studies of good reliability (reliability 1) where rats were exposed 6 hours per day for 13 weeks to vapor concentration of Naphtha up to levels of 20 mg/L, with no treatment related mortalities. Therefore, no classification for acute inhalation toxicity is warranted.
The data do not meet the criteria for hazard classification for acute, dermal or inhalation toxicity according to EU CLP Regulation (EC No. 1272/2008); however, warnings for aspiration hazard and potential narcotic effects at high concentrations should be considered.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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