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Diss Factsheets
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EC number: 225-218-5 | CAS number: 4724-48-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
The acute toxicity of octylphosphonic acid (OPA) has been studied by oral and dermal routes. For oral toxicity, the study by HOEC (1979) (Rel. 2) in rats has been chosen as key study. Based on the results of this study, OPA is classified into category 4, H302 according to EU Regulation criteria. The key study for dermal toxicity (Rel. 1) is Allen (1997). No study on acute inhalation toxicity is required since the substance is a waxy solid with very low vapour pressure, and is corrosive to the skin.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 890 mg/kg bw
- Quality of whole database:
- The study is a GLP compliant and has Klimisch score 2
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The study is a GLP compliant and has Klimisch score 1
Additional information
Oral Toxicity
In the key study Hoechst (1979) in female rats, the LD50 was 1890 mg/kg bw. Macroscopic examination of the decedents showed thickening of the stomach, stomach ruptured, substance in the abdominal cavity, suprarenal bodies discolored dark-red/brown, reddened gastric mucosa. No macroscopic effects or effects on bodyweight gain were seen in survivors. The LD 50 for female was 1890 mg/kg bw.
In the supporting study by Guest (1993) the LD50 for male and female rats was > 2000 mg/kg bw. There was no evidence of systemic toxicity. The only effects noted were white thickening of approximately one half of the area of the no glandular epithelium of the stomach, indicative of the corrosive effects of the test substance.
Dermal Toxicity
In the key study by Allen (1997), the dermal LD50 value in rats was > 2000 mg/kg bw. No systemic toxicity was reported but irritant effects persisted to the end of the observation period.
Inhalation Toxicity
No study on acute inhalation toxicity is required since the substance is a waxy solid with very low vapour pressure (1.6E-04 Pa at 25 °C), and is corrosive to the skin (Cat1B, H314).
Justification for selection of acute toxicity – oral endpoint
The reliability of the study in K2, in accordance with GLP and guideline. Based on the results of this study, OPA is classified into category 4, H302.
Justification for selection of acute toxicity – inhalation endpoint
Waiver
Justification for selection of acute toxicity – dermal endpoint
Only one study available
Justification for classification or non-classification
Oral:
As the LD50/rat females is 1890 mg/kg bw, OPA is classified for acute oral toxicity into category 4, H302 according to the regulation (EC) N°.1272/2008 and as Xn R22 according to the Directive 67/548/EEC criteria.
Dermal:
The limit value for classification of a substance as harmful on acute exposure by the dermal route according to the criteria of Annex VI Directive 67/748/EEC (R21) and the regulation (EC) N°.1272/2008criteria (Acute toxicity Cat. 4) is dermal LD50 2000 mg/kg. The available study on OPA gives LD50 > 2000 mg/kg. OPA is therefore not classified for acute dermal toxicity according to the regulation (EC) N°.1272/2008 and the Directive 67/548/EEC criteria.
Inhalation:
No study on acute inhalation toxicity is available or required. No classification is possible due to lack of data
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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