Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 249-079-5 | CAS number: 28553-12-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report, GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
- Type of study / information:
- A study consisting of a single 24-hour application using an occluded patch was conducted to evaluate the potential to cause irritation. Two evaluations were made; one 30 minutes after patch removal and the second at 24 hours post-patch removal. Two control were also tested; a positive irritant control and a negative control.
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A single 24-hour exposure was used.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,2-Benzenedicarboxylic acid, di-C8-10-branched alkyl esters, C9-rich
- EC Number:
- 271-090-9
- EC Name:
- 1,2-Benzenedicarboxylic acid, di-C8-10-branched alkyl esters, C9-rich
- Cas Number:
- 68515-48-0
- Molecular formula:
- C26 H42 O4
- IUPAC Name:
- 1,2-Benzenedicarboxylic acid, di-C8-10-branched alkyl esters, C9-rich
- Reference substance name:
- DINP
- IUPAC Name:
- DINP
- Details on test material:
- - Name of test material (as cited in study report): MRD 95-140
- Substance type: liquid
- Analytical purity: assumed 100 %
Constituent 1
Constituent 2
Method
- Ethical approval:
- confirmed and informed consent free of coercion received
- Details on study design:
- Health male and female volunteers were entered into the study. Each test patch received 0.1 – 0.3 ml of the assigned test article. The final quantity dispensed is dependent upon the nature of the test material. Each subject will receive a single 24 +/- 1 hour contact application to specific skin sites of the paraspinal region of the back. All applications and patch removal will be conducted by a technician at the laboratory. Sites are scored at 30 minutes post-patch removal and 24 hours post-patch removal. Scoring of irritation was conducted by an experienced technical staff member using a 0-3 grade scoring scale for erythema and edema (3 being the most severe).
- Exposure assessment:
- not specified
- Details on exposure:
- TYPE OF EXPOSURE:
Occluded patch
EXPOSURE LEVELS:
0.3-0.5 ml
EXPOSURE PERIOD:
24 hours
POSTEXPOSURE PERIOD:
24 hours
Results and discussion
- Results:
- The group mean score for irritation was 0.00
Applicant's summary and conclusion
- Conclusions:
- Not irritating.
- Executive summary:
MRD 95-140 (CAS 68515-48-0) was applied undiluted (0.2 ml) for 24 hours to human volunteers (fourteen female and one male subject) using an occluded patch applied to specific skin sites of the paraspinal region of the back, and was followed by an observation period of 24 hours. Two controls were also tested: a positive irritant control of 0.5% sodium lauryl sulphate in distilled water and a negative control of 0.89% NaCl in distilled water. No responses were observed. Mild to moderate erythema was observed with the positive irritant control at the 30-minute or 24 hour evaluation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.