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EC number: 249-079-5 | CAS number: 28553-12-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable, well documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- Principles of method if other than guideline:
- In principle, the methods described in OECD Guideline 401 were used.
Young adult laboratory rats were purchased from a breeder. 5 rats per sex were treated simultaneously by gavage without a vehicle.
Documentation of clinical signs was performed over a 14 day period. Body weight was determined before the start of the study only, as it was needed for determination of dose.
The clinical signs and findings were reported. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Di-''isononyl'' phthalate
- EC Number:
- 249-079-5
- EC Name:
- Di-''isononyl'' phthalate
- Cas Number:
- 28553-12-0
- Molecular formula:
- C26H42O4
- IUPAC Name:
- 1,2-bis(7-methyloctyl) benzene-1,2-dicarboxylate
- Reference substance name:
- DINP
- IUPAC Name:
- DINP
- Details on test material:
- purity >99%
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 10000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Mortality:
- no animal died within the observation period
- Clinical signs:
- other: other:
Any other information on results incl. tables
Mortality after |
5 males |
5 females |
1 h |
0 |
0 |
1 d |
0 |
0 |
2 d |
0 |
0 |
7 d |
0 |
0 |
14 d |
0 |
0 |
Symptoms in all animals at 10000 mg/kg:
DYSPNEA, APATHY, SPASTIC MOTION, SCRUBBY FUR, ALOPECIA, BAD GENERAL CONDITION
Applicant's summary and conclusion
- Executive summary:
No death and no abnormalities observed upon terminal necropsy at a dose level of 10,000 mg/kg Palatinol CE 5250 (CAS 28553-12-0, DINP2) administered undiluted by gavage to ten Sprague- Dawley rats (5 males and 5 females). The observation period was 14 days. Dyspnea, apathy, spastic gait, piloerection, alopecia and poor general state were observed.
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