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Diss Factsheets
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EC number: 203-470-7 | CAS number: 107-18-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
- acute tox (oral, rat) LD50 = 64 mg/kg bw
(Gardner 's Commercially Important Chemicals, 2005)
- acute tox (oral, rat) LD50 = 99 - 105 mg/kg bw (Dunlap, 1958)
- acute tox (oral, rabbit) LD50 = 72 mg/kg bw (Dunlap, 1958)
- acute tox (inhalation, 4h, rat) LC50 = 300 -330 mg/m³ (Dunlap, 1958)
- acute tox (dermal, rabbit) LD50 = 89 mg/kg bw (Dunlap, 1958)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed handbook
- Qualifier:
- according to guideline
- Guideline:
- other: no data
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- other: no data
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- other: no data
- Vehicle:
- not specified
- Control animals:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 64 mg/kg bw
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- LD5O (rat) = 64 mg/kg bw
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 64 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not applicable
- GLP compliance:
- no
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- male
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- >= 1 - <= 8 h
- Concentrations:
- 95-5450 mg/m3 (nominal).
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 1 900 - 2 130 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 300 - 330 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 140 - 150 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- Toxicity in the lung (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) was observed.
The LC50 for 1, 4 and 8 hours were 1900 -2130, 300-330 and 140-150 mg/m³, respectively. - Executive summary:
Rats (Long-Evans; 6 males/group) were exposed for 1, 4 or 8 hours to allyl alcohol at concentrations between 95-5450 mg/m³ (nominal). Coma and diarrhoea were observed. On histopathological examination, toxicity in the lung (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) was observed. The LC50 for 1, 4 and 8 hours were 1900 -2130, 300-330 and 140-150 mg/m³, respectively.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 300 mg/m³ air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not applicable
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 h
- Doses:
- 25 - 200 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- Toxicities in the lungs (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) were observed. The LD50 was 89 mg/kg bw.
- Executive summary:
Rabbits (3 males/group) were exposed for 24 hours to 25 - 200 mg/kg bw of 2-propen-1-ol (applied by injecting the 2-propen-1-ol though the occlusive dressing onto the surface of the skin and sealing the puncture site with rubber cement). Apathy, along with flushing of the skin, ataxia and diarrhoea were observed. On histopathological examination, toxicities in the lungs (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) were observed. The LD50 was 89 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 89 mg/kg bw
Additional information
Justification for classification or non-classification
Acute toxicity oral: according to CLP classification criteria, the substance meets the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) No. 1272/2008: Category 3; H 301: toxic if swallowed.
The CLP classification is in accordance with the one listed for allyl alcohol in Annex VI (EC No. 1272/2008).
Acute toxicity inhalation: according to CLP classification criteria, the substance meets the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) No. 1272/2008: Category 2; H330: fatal if inhaled.
The CLP classification is a more severe classification than given in Annex VI (EC No. 1272/2008):
Category 3 (with an asterisk that indicates the minimum classification).
Acute toxicity dermal: according to CLP classification criteria, the substance meets the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) No. 1272/2008: Category 2; H310: fatal in contact with skin.
The CLP classification is a more severe classification than given in Annex VI (EC No. 1272/2008):
Category 3 (with an asterisk that indicates the minimum classification).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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