Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 266-719-9 | CAS number: 67564-91-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The bioaccumulation potential of the test substance fenpropimorph in Oncorhynchus mykiss and Lepomis macrochirus was assessed in three experimental studies. For fenpropimorph and its metabolites a BCF value in the tested species between 968 and 1145 was determined.
Additional information
In the key study (2003/1009213) The uptake of fenpropimorph in rainbow trout showed to have reached steady-state conditions within 19 days. The bioconcentration factor BCFss based on measured radioactivity in tank water and fish resulted in 1145 for whole fish of the phenyl label and correspondingly in 968 for the morpholine label at steady-state. The depuration of 95% of the residues at the plateau level lasted up to about 56 days. The calculated depuration half-life resulted in 1.4 days for phenyl labelled fenpropimorph and 1.3 days for the morpholine labelled, respectively. The time of 90% elimination was calculated to 4.7 days and 4.2 days, respectively. The kinetic bioconcentration factors BCFk as the ratio of the uptake rate and the depuration rate constants resulted in 1169 (phenyl labelled fenpropimorph) and 1220 (morpholine labelled fenpropimorph) for whole fish. These data are very similar to the BCFss values from direct calculation of the radioactivity measurements of water and fish samples at steady-state.
Metabolisation of fenpropimorph was detected in edible and inedible fish tissue accordingly. Predominant metabolite was the glucuronic acid conjugate BF 421-1-Gluc.A. with up to more than 50% of the radioactive residue.
Two supplementary studies with the bluegill sunfish (Lepomis macrochirus) are available. With phenyl labelled fenpropimorph the observed bioaccumulation factors were 616, 1842 and 1096 for edibles, non-edibles and whole fish, respectively (RCC, 88/10146). The parent compound accounted for the major part of residual radioactivity in the edible parts of fish after 21 end 28 days of exposure. Next to the parent molecule, almost exclusively BF 421-7 and 4-[3-(4-tert-butylphenyl)-2-methyl-1-oxopropyl]-2,6-dimethylmorpholine (BF 421-13) were detected in about 4 to 5 times lower amounts.
Depuration was observed with half-lives of 4.3, 5.3 and 4.8 days for edibles, non-edibles and whole fish, respectively.
Furthermore with morpholine labelled fenpropimorph the observed bioaccumulation factors were 598, 1471 and 942 for edibles, non-edibles and whole fish, respectivly. The parent compound accounted for the major part of residual radioactivity in the edible parts of fish after 21 and 28 days of exposure. Next to the parent molecule, almost exclusively BF 421-7 and 4-[3-(4-tert-butylphenyl)-2-methyl-1-oxopropyl]-2,6-dimethylmorpholine (BF 421-13) were detected in about 4 to 10 times lower amounts. Depuration was observed with half-lives of 8.0. 4.9 and 5.9 days for edibles, non-edibles and whoIe fish, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.