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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-458-1 | CAS number: 107-06-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to terrestrial plants
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to terrestrial plants: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data available
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Publicly available, well documented literature study.
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- The germination rate of the pollen was determined by applying a modified test procedure originally developed by Kappler and Kirsten (Pollen test system. The toxicity of chemicals is determined by measuring inhibition of pollen tube growth)
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
no data available - Analytical monitoring:
- no
- Details on sampling:
- not applicable
- Vehicle:
- not specified
- Details on preparation and application of test substrate:
- An amount of 0.5 mg pollen and 1 mL germination medium was placed into 3.5 cm Petri dishes and held in a water saturated atmosphere.
- Species:
- other: Nicotiana tabacum
- Plant group:
- Dicotyledonae (dicots)
- Details on test organisms:
- Plants were raised under greenhouse conditions, such that enough pollen was available throughout the year. Immediately after anthesis, the pollen was directly dusted into Eppendorf-tubes and stored at -20 °C until use. Only pollen from plants showing viability of more than 70 % was used in the experiments.
- Test type:
- other: germination test
- Study type:
- laboratory study
- Substrate type:
- other: petri dish + germination medium
- Limit test:
- no
- Total exposure duration:
- 2 h
- Test temperature:
- 22 °C
- pH:
- no data available
- Moisture:
- water saturated air
- Details on test conditions:
- Petri dishes (including pollen and germination medium) are put into small glass troughs (8.5 x 5.7 x 6.7 cm) and sealed tightly. The test substance was injected by a GC-syringe into the trough where it evaported at once. As a control the same amount of water was injected into the control troughs.
- Nominal and measured concentrations:
- no data available
- Reference substance (positive control):
- no
- Species:
- other: Nicotiana tabacum
- Duration:
- 2 h
- Dose descriptor:
- other: ED50 (Effective Dose)
- Effect conc.:
- 17.1 other: mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- germination
- Species:
- other: Nicotiana tabacum
- Duration:
- 2 h
- Dose descriptor:
- other: ED25
- Effect conc.:
- 9.2 other: mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- germination
- Details on results:
- For each concentration of the test item three seperate tests are investigated. The mean values of these three tests are used to calculate a dose response curve. The inhibition rate is calculated by setting the germination rate of the control (70 - 85 % of total amount) at 100 %.
- Results with reference substance (positive control):
- no data available
- Reported statistics and error estimates:
- ED50 value was calculated by linear interpolation.
- Conclusions:
- In a 2 h germination test the ED50 of Nicotiana tabacum pollen was determined to be 17.1 mg 1,2-dichloroethane/cm2 (no 95 % Confidence Intervals are available).
- Executive summary:
The stimulation of pollen germination of 1,2 -dichloroethane to Nicotiana tabacum pollen, was determined in a 2 -hour germination test. Treatments consisted of a dilution water control and at test substance concentrations.
Reference
Description of key information
The ED50 of Nicotiana tabacum pollen was determined to be 17.1 mg 1,2-dichloroethane/cm2 (no 95 % Confidence Intervals are available).
Key value for chemical safety assessment
Additional information
The stimulation of pollen germination of 1,2-dichloroethane to Nicotiana tabacum pollen, was determined in a 2 -hour germination test. Treatments consisted of a dilution water control and at test substance concentrations.
The ED50 of Nicotiana tabacum pollen was determined to be 17.1 mg 1,2-dichloroethane/cm2 (no 95 % Confidence Intervals are available).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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