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Diss Factsheets
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EC number: 203-919-7 | CAS number: 111-90-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
The mutagenicity of 2 -(2 -ethoxyethoxy)ethanol has been studied in Salmonella typhimurium strains TA98, TA100, TA102, TA1535, and TA1537. Three independent experiments were conducted at 52, 162, 512, 1600 and 5000ug/plate; 492, 878, 1568, 2800 and 5000ug/plate and 10, 33, 100, 333 and 1000ug/plate respectively, with and without S9 metabolic activation systems. No signs of cytotoxicity and no precipitate were observed up to the highest dose tested, and the test article did not induce any biological relevant or statistically significant increases in the number of revertants in any of the 5 test strains, either with or without metabolic activation. Therefore, the test substance is considered non-mutagenic under the conditions of this study.
Male mice were treated intraperitoneally with 2 -(2 -ethoxyethoxy)ethanol for two consecutive days at 2ml/kg/day. A positive control group was given 100mg/kg benzopyrene. Analysis of PCE in bone marrow of animals at 48 hours and 72 hours demonstrated that the substance did not induce micronuclei whereas the number of micronuclei observed in positive control animals was increased at both time points.
In a GLP guideline study in male rats, the potential of 2 -(2 -ethoxyethoxy)ethanol to induce unschedule DNA synthesis was examined. The test substance was administered once orally by gavage at 800 or 2000mg/kg. Approximately 12-14 hours (Experiment 1) or 2-4 hours after dosing (Experiment 2), animals were killed and their livers perfused with collagenase to provide a primary culture of hepatocytes. The test substance did not product a group mean net grain count value greater than -1.7 nor were any more than 0.7% cells found in repair at either dose or experiment. Negative (vehicle) control NNG value was consistent with both published and historical control data, and the system was shown to be sensitive to two positive controls. It is concluded that 2 -(2 -ethoxyethoxy)ethanol failed to induce UDS detectable under the experimental conditions employed.
Short description of key information:
Ames tests: negative
In vivo micronucleus test: negative
In vivo liver UDS assay: negative
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Data does not indicate and genotoxic effects that would warrant classification.
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