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Diss Factsheets
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EC number: 915-069-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-06-05 to 1991-06-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)
- Version / remarks:
- adopted May 12, 1981
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Directive A.7 "fat solubility"
- Version / remarks:
- EEC Directive 84/449 EEC, EEC Publication No. L251, September 1984
- Deviations:
- no
- GLP compliance:
- yes
- Medium:
- standard fat
- Solubility:
- < 6.8 other: mg/100 g standard fat
- Temp.:
- 37 °C
- Test substance stable:
- yes
- Details on results:
- The measured concentrations of Al in the samples were not very accurate due to a high background level in the samples to be analysed. Only the Ca values were considered for the calculation of the concentration of the test substance.
No significant differences were observed in the results from 3 and 24 hours stirring period as well as in the results from the under- and oversaturation group after both the 3 and 24 hours stirring period. Therefore, the test was considered valid. The fat solubility was calculated as the mean value of all measurements. Because the value for the blank is < 5.6 mg/100 g, no correction for the blank was made. Therefore, the fat solubility of the test substance is given as a maximum value.
The solubility of substance "reaction mass of calcium hydrogen phosphonate and dialuminium tricalcium hexaoxide" in standard fat HB 307 was determined to be < 68 +/- 4 x 10exp-3 g/kg, i.e. < 6.8 +/- 0.4 mg/100 g, at 37.0 + 0.5°C. - Conclusions:
- Solubility in standard fat HB 307 < 68 +/- 4 x 10exp-3 g/kg, i.e. < 6.8 +/- 0.4 mg/100 g, at 37.0 +/- 0.5°C.
- Executive summary:
The fat solubility of substance "reaction mass of calcium hydrogen phosphonate and dialuminium tricalcium hexaoxide" (a.i. 90 %) was measured in a study performed as flask method according to EU Method A.7 (Fat Solubility), 1984 and OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances), 1981.
An amount of approximately 0.38-0.50 g of the test substance was weighed into each of eight Erlenmeyer flasks. To each flask, 50 mL liquefied and mixed standard fat was added after which the flasks were securely closed. A commercially available standard fat (HB 307, NATEC, Institut für naturwissenschaftlich-technische Dienste GmbH, Hamburg, FRG) was used. This fat simulant is a synthetic mixture of saturated triglycerides with a fatty acid and triglyceride distribution similar to that of a coconut fat. One half of the flasks was placed in a thermostatically controlled water bath at 30°C and the other half was placed in a thermostatically controlled water bath at 50°C. The content of each flask was shaken for 1 hour. Thereafter, two flasks in both groups were shaken for 3 hours whereas the third and fourth flasks in both groups were shaken for 24 hours in thermostatically controlled water bath at 37 +/- 0.5°C. After the stirring periods at 37°C, the concentration of the test substance in the fat phases was determined. Samples of approximately 40 mL were taken and centrifuged for 10 minutes at 3500 g and 37°C. The supernatant was pipetted off and centrifuged a second time (same conditions). This was repeated once. The fat samples were decomposed by a high pressure nitrous acid digestion (Carius digestion). Al and Ca were determined by atomic absorption spectrometry (AAS). Al was determined by electrothermal atomization (ETA-AAS) in the graphite furnace and Ca was determined by flame atomization in a nitrous oxide/acetylene flame.
The measured concentrations of Al in the samples were not very accurate due to a high background level in the samples to be analysed. Only the Ca values were considered for the calculation of the concentration of the test substance.
No significant differences were observed in the results from 3 and 24 hours stirring period as well as in the results from the under- and oversaturation group after both the 3 and 24 hours stirring period. Therefore, the test was considered valid. The fat solubility was calculated as the mean value of all measurements. Because the value for the blank is < 5.6 mg/100 g, no correction for the blank was made. Therefore, the fat solubility of the test substance is given as a maximum value.
The solubility of substance "reaction mass of calcium hydrogen phosphonate and dialuminium tricalcium hexaoxide" in standard fat HB 307 was determined to be < 68 +/- 4 x 10exp-3 g/kg, i.e. < 6.8 +/- 0.4 mg/100 g, at 37.0 +/- 0.5°C.
Reference
Description of key information
Solubility in standard fat HB 307 was determined to be < 68 +/- 4 x 10exp-3 g/kg, i.e. < 6.8 +/- 0.4 mg/100 g, at 37.0 +/- 0.5°C.
EU Method A.7 (Fat Solubility), 1984 and OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances), 1981
Key value for chemical safety assessment
Additional information
Value used for CSA: < 6.8 +/- 0.4 mg/100 g standard fat at 37.0 +/- 0.5 °C
The fat solubility of substance "reaction mass of calcium hydrogen phosphonate and dialuminium tricalcium hexaoxide" (a.i. 90 %) was measured in a study performed as flask method according to EU Method A.7 (Fat Solubility), 1984 and OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances), 1981.
An amount of approximately 0.38-0.50 g of the test substance was weighed into each of eight Erlenmeyer flasks. To each flask, 50 mL liquefied and mixed standard fat was added after which the flasks were securely closed. A commercially available standard fat (HB 307, NATEC, Institut für naturwissenschaftlich-technische Dienste GmbH, Hamburg, FRG) was used. This fat simulant is a synthetic mixture of saturated triglycerides with a fatty acid and triglyceride distribution similar to that of a coconut fat. One half of the flasks was placed in a thermostatically controlled water bath at 30°C and the other half was placed in a thermostatically controlled water bath at 50°C. The content of each flask was shaken for 1 hour. Thereafter, two flasks in both groups were shaken for 3 hours whereas the third and fourth flasks in both groups were shaken for 24 hours in thermostatically controlled water bath at 37 +/- 0.5°C. After the stirring periods at 37°C, the concentration of the test substance in the fat phases was determined. Samples of approximately 40 mL were taken and centrifuged for 10 minutes at 3500 g and 37°C. The supernatant was pipetted off and centrifuged a second time (same conditions). This was repeated once. The fat samples were decomposed by a high pressure nitrous acid digestion (Carius digestion). Al and Ca were determined by atomic absorption spectrometry (AAS). Al was determined by electrothermal atomization (ETA-AAS) in the graphite furnace and Ca was determined by flame atomization in a nitrous oxide/acetylene flame.
The measured concentrations of Al in the samples were not very accurate due to a high background level in the samples to be analysed. Only the Ca values were considered for the calculation of the concentration of the test substance.
No significant differences were observed in the results from 3 and 24 hours stirring period as well as in the results from the under- and oversaturation group after both the 3 and 24 hours stirring period. Therefore, the test was considered valid. The fat solubility was calculated as the mean value of all measurements. Because the value for the blank is < 5.6 mg/100 g, no correction for the blank was made. Therefore, the fat solubility of the test substance is given as a maximum value.
The solubility of substance "reaction mass of calcium hydrogen phosphonate and dialuminium tricalcium hexaoxide" in standard fat HB 307 was determined to be < 68 +/- 4 x 10exp-3 g/kg, i.e. < 6.8 +/- 0.4 mg/100 g, at 37.0 +/- 0.5°C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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