Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Ethylbenzene
  • IUPAC name: ethylbenzene
  • Other names
EC / List no.:
202-849-4
CAS no.:
100-41-4
Index number:
601-023-00-4
Molecular formula:
C8H10
SMILES:
CCC1=CC=CC=C1
InChI:
InChI=1S/C8H10/c1-2-8-6-4-3-5-7-8/h3-7H,2H2,1H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
11
Of which contain:
8 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP06) approved by the European Union, this substance may be fatal if swallowed and enters airways, is a highly flammable liquid and vapour, is harmful if inhaled and may cause damage to organs through prolonged or repeated exposure.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may cause genetic defects, may cause cancer, is harmful to aquatic life with long lasting effects and is harmful if swallowed.

Breakdown of all 7375 C&L notifications submitted to ECHA

Flam. Liq. 2 H225 Harmonised Classification
Acute Tox. 4 H332 Harmonised Classification
Asp. Tox. 1 H304 Harmonised Classification
STOT RE 2 H373 Harmonised Classification
Aquatic Chronic 3 H412
Eye Irrit. 2 H319
Skin Irrit. 2 H315
STOT SE 3 H335
STOT SE 3 H336
Carc. 2 H351
Acute Tox. 4 H312
Flam. Liq. 3 H226
Acute Tox. 4 H302
Not Classified
Asp. Tox. 2 H304
https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • C*
  • M*

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 24 active registrations under REACH, 1 Joint Submission(s) and 1 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 000 000 - 10 000 000 tonnes per year.

This substance is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates) and manufacturing of the substance.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: coating products.

This substance is used in the following areas: building & construction work. This substance is used for the manufacture of: plastic products, mineral products (e.g. plasters, cement) and furniture.

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, roller or brushing applications, non-industrial spraying, treatment of articles by dipping and pouring and hand mixing with intimate contact only with personal protective equipment available.

Other release to the environment of this substance is likely to occur from: indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

This substance is used in the following products: polymers, coating products, fuels and inks and toners.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers, laboratory work and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: coating products, polymers and inks and toners. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, laboratory work and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, laboratory work and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; ground and bond container and receiving equipment; take actions to prevent static discharges; do not breathe the dust, fume, gas, mist, vapours or spray; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use only outdoors or in a well-ventilated area; obtain special instructions before use; keep container tightly closed; use personal protective equipment as required.; use explosion-proof equipment (electrical/ventilating/lighting/etc.); avoid release to the environment; use non-sparking tools; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: Call a poison center or doctor/physician if you feel unwell. If swallowed: immediately call a poison center or doctor/physician. If exposed or concerned: get medical advice/attention. If exposed or concerned: follow instructions specified by manufacturer/supplier. Get medical advice/attention if you feel unwell. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. In case of fire: Use (measures specified by manufacturer/supplier) for extinction. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. If swallowed: follow instructions specified by manufacturer/supplier. Do not induce vomiting.

Storage statements

Store this substance in a well-ventilated place and Keeping it cool; locked up.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • ARKEMA Gmbh, Tersteegenstrasse 28 40401 Düsseldorf Germany
  • BASF Antwerpen N.V., Haven 725, Scheldelaan 600 2040 Antwerpen 4 Antwerpen Belgium
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • COVANCE CRS SA 013, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • Essar Oil (UK) Limited, Stanlow Manufacturing Complex PO Box 3 CH65 4HB Ellesmere Port Cheshire United Kingdom
  • Gazprom Marketing and Trading France16, 68 avenue des Champs-Elysées 75008 Paris France France
  • INEOS Styrenics GmbH, Paul-Baumann-Strasse 1 D-45764 Marl Germany
  • INEOS Styrolution Belgium, Haven 725, Scheldelaan 600 Scheldelaan 600 2040 Antwerpen 4 Belgium
  • Interchem Logistics B.V., Javastraat 4 3016 CE Rotterdam Netherlands
  • Lyondell Chemie Nederland B.V., Deltseplein 27E 3013 AA Rotterdam Netherlands
  • PPG Industries Italia Srl Società soggetta a direzione e coordinamento da parte di PPG Industries Inc., Via Serra, 1 15028 Quattordio Italy
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • REPSOL QUÍMICA, Calle Mendez Alvaro, 44 28045 Madrid Madrid Spain
  • Shell Chemicals Europe B.V., Weena 70 3012 CM Rotterdam Netherlands
  • Shell Nederland Chemie B.V., Vonderlingenweg 601, Att. G-J Dijkema WO 503200019 PO BOX 8610, 3009 AP Rotterdam Netherlands
  • SUEZ Water Technologies & Solutions Belgium BVBA, Toekomstlaan 54 2200 Herentals Belgium
  • SUEZ WTS France, Tour CB21 16 Place de l’Iris 92040 Paris La Défense France
  • Sustainability Support Services (Europe) AB, Markaskälsvägen 6 22647 Lund Sweden
  • SYNTHOS Kralupy a.s., O.Wichterleho 810 27801 Kralupy nad Vltavou Czech Republic
  • Total Petrochemicals France SA, Immeuble Le Linéa 1, rue du Général Leclerc 92047 Paris La Défence Cedex France
  • Total Raffinage France, 2, place Jean Millier, La Défense 92400 Courbevoie France
  • Trinseo Deutschland GmbH, Strasse E 17 06258 Schkopau Germany
  • Trinseo Netherlands B.V., Herbert H. Dowweg 5 4542 NM Hoek Netherlands
  • versalis S.p.A., P.zza Boldrini 1 20097 San Donato Milanese MILANO Italy
  • Ecotoxward Ltd, 381 -383 City Road EC1V 1NW London United Kingdom
  • SLOVNAFT, a.s., Vlcie hrdlo 1 824 12 Bratislava Slovakia

Other names

  • -
  • 20479_100-41-4
  • Benzene, ethyl-
  • Ethyl benzene
  • Ethyl-benzene
  • ethylbenze
  • Ethylbenzen
  • ETHYLBENZENE
  • Ethylbenzol
  • .alpha.-Methyltoluene
  • Benzene, ethyl- (7CI, 8CI, 9CI)
  • benzene,ethyl-
  • EB
  • Ethylbenzene
  • Ethylbenzene E
  • Ethylbenzene fraction
  • Ethylbenzol
  • Phenylethane

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 3 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [2]
C Form
Other (100%) [1]
C Odour
Characteristic of aromatic compounds (50%), Other (50%) [2]
C Substance type
Organic (100%) [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 6 studies submitted
  • 4 studies processed
R Melting / freezing point
-95 - -27.07 °C @ 101.3 kPa [6]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence 2 1
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
-95.15 - -94.9 °C

Boiling point

Study results
  • 6 studies submitted
  • 4 studies processed
R Boiling point
136 - 148.3 °C @ 101.33 kPa [4]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence 2 1
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Boiling point at 101 325 Pa
136.1 °C

Density

Study results
  • 5 studies submitted
  • 1 study processed
R Relative density
0.86 - 0.87 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
0.867 - 868

Vapour pressure

Study results
  • 7 studies submitted
  • 4 studies processed
R Vapour pressure
9 - 13.106 hPa @ 20 - 25 °C [11]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence 2 1
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
9.52 - 10.1 hPa @ 19.85 - 25 °C

Partition coefficient

Study results
  • 10 studies submitted
  • 4 studies processed
R Pow
4 170 @ 20 °C and pH 7.84 [1]
R Log Pow
3.03 - 3.6 @ 20 °C and pH 7.84 [4]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 4
Weight of evidence 2 1
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
3.03 - 3.6 @ 20 °C

Water solubility

Study results
  • 10 studies submitted
  • 4 studies processed
R Water solubility (mass/vol.)
157.63 - 228.6 mg/L @ 25 °C [4]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence 3 2
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Water solubility
200 mg/L @ 25 °C

Solubility in organic solvents / fat solubility

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Surface tension

Study results
  • 2 studies submitted
  • 1 study processed
R Surface tension
71.2 mN/m @ 58.2 mg/L and 23 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 6 studies submitted
  • 3 studies processed
R Flash point
12.8 - 23 °C @ 101.3 kPa [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence 2
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Flash point at 101 325 Pa
22.85 °C

Auto flammability

Study results
  • 5 studies submitted
  • 3 studies processed
R Autoflammability / self-ignition
430 - 432.222 °C @ 101.3 kPa [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 2
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Autoflammability / self-ignition at 101 325 Pa
429.85 - 432 °C

Flammability

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Highly flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 8 studies submitted
  • 3 studies processed
R Other:
0.64 [1]
R kinematic viscosity (in mm²/s)
0.6 - 0.773 [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 4
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Static viscosity at 20 °C
0.6 - 0.773 mm²/s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 2 4
Weight of evidence 1
Other 2
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Half life in air
43.2 - 55.2 h

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in soil

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water - screening tests

Study results
  • 37 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 2 24
Weight of evidence 1
Other 1 8
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1 3
Weight of evidence 1
Other 3
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
110 L/kg ww

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Adsorption/desorption

Study results
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2 2
Weight of evidence 1
Other 1 3
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Koc at 20°C
1 331

Henrys law constant (H)

Study results
  • 3 studies submitted
  • 2 studies processed
R H - (pressure) m³/mol
799.454 - 900 Pa m³/mol @ 25 °C [5]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Henry's law constant
854.17 Pa.m³.mol-1 @ 20 °C

Distribution modelling

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 1
Other 2
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 100 µg/L (2)
Intermittent releases (freshwater) 100 µg/L (1)
Marine water 10 - 100 µg/L (2)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 9.6 mg/L (1)
Sediment (freshwater) 13.7 mg/kg sediment dw (1)
Sediment (marine water) 1.37 mg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 2.68 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 20 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 20 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 4.2 - 5.1 mg/L [2]
LC50 (72 h) 5.8 mg/L [1]
LC50 (48 h) 6.4 mg/L [1]
LC50 (24 h) 7 mg/L [1]
NOEC (4 days) 3.3 mg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 2 2
Weight of evidence 1 1
Other 12
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
LC50 for freshwater fish
4.2 mg/L
LC50 for marine water fish
5.1 mg/L

Long–term toxicity to fish

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 20 studies submitted
  • 3 studies processed
P/RResults
EC50 (48 h) 1.8 - 2.4 mg/L [1]
EC50 (24 h) 2.4 - 2.8 mg/L [1]
IC50 (7 days) 3.3 mg/L [1]
LC50 (7 days) 3.6 mg/L [1]
LC50 (4 days) 2.6 mg/L [1]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 6
Weight of evidence 1
Other 10
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
1.8 mg/L
EC50 / LC50 for marine invertebrates
2.6 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (7 days) 960 µg/L [1]
LOEC (7 days) 1.7 mg/L [1]
LC50 (7 days) 3.6 mg/L [1]
LC50 (48 h) 3.2 mg/L [1]
IC50 (7 days) 3.3 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
1 mg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 15 studies submitted
  • 2 studies processed
P/RResults
EC50 (4 days) 3.6 - 7.7 mg/L [2]
EC50 (72 h) 4.9 - 5.4 mg/L [2]
EC50 (48 h) 7.2 - 7.5 mg/L [2]
EC50 (24 h) 8 - 13.4 mg/L [2]
NOEC (4 days) 3.4 - 4.5 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 3 2
Weight of evidence 1
Other 7
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
EC50 for freshwater algae
3.6 mg/L
EC50 for marine water algae
7.7 mg/L
EC10 or NOEC for freshwater algae
3.4 mg/L
EC10 or NOEC for marine water algae
4.5 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 20 studies submitted
  • 1 study processed
P/RResults
EC50 (24 h) 96 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 4
Weight of evidence 1
Other 13
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
EC50 for microorganisms
96 mg/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
LC50 (48 h) 4 700 g/ha [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other 1
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 77 mg/m³ repeated dose toxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: No hazard identified
Acute /short term: (DNEL) 293 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 180 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 15 mg/m³ repeated dose toxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.6 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 57 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 5 6
Supporting study 13 27
Weight of evidence 3
Other 3
Data waiving
no waivers
Study data: dermal absorption
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1 3
Supporting study 1 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 5 studies submitted
  • 4 studies processed
P/RResults
rat 48 h () [2]
LD50 3 500 mg/kg bw (rat) [1]
M/CInterpretations of results
Not classified [2]

Type of Study provided
oral
Studies with data
Key study 1 1
Supporting study
Weight of evidence 2
Other 1
Data waiving
no waivers
inhalation
  • 11 studies submitted
  • 4 studies processed
P/RResults
rat (3 500 mg/kg bw) () [1]
M/CInterpretations of results
Not classified [3]

inhalation
Studies with data
Key study 1 2
Supporting study 4
Weight of evidence 1
Other 3
Data waiving
no waivers
dermal
  • 3 studies submitted
  • 2 studies processed
P/RResults
rabbit 3 500 mg/kg bw (rat) [1]
LD50 17.8 mL/kg bw (rabbit) [1]
M/CInterpretations of results
Not classified [1]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other 1
Data waiving
no waivers
other routes
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 3 500 mg/kg bw
Inhalation route:
No adverse effect observed LC50 17 629 mg/m³
Dermal route:
No adverse effect observed LD50 15 400 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: eye
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Sensitisation

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 4 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 75 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: inhalation
  • 21 studies submitted
  • 11 studies processed
P/RResults
rat (rat): 75 mg/kg bw/day [2]
mouse (rat): 75 mg/kg bw/day [2]
NOAEC (rat): 250 - 1 000 ppm [3]
NOAEC (mouse): 75 - 1 000 ppm [3]
NOAEC (rabbit): 1 600 ppm [1]

Study data: inhalation
Studies with data
Key study 7
Supporting study 5
Weight of evidence 5
Other 4
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 75 mg/kg bw/day (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 23 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2
Supporting study 7 6
Weight of evidence 1 1
Other 3 3
Data waiving
no waivers
Study data: in vivo
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study 2
Weight of evidence 1
Other 2
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 15 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 4
Supporting study 6 2
Weight of evidence 2
Other 1
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: developmental
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study 3 1
Weight of evidence
Other 3 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: other studies
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study 3
Supporting study 7
Weight of evidence
Other 6
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Inhalation route:
No adverse effect observed NOAEC 4 342.13 mg/m³ (subacute, rat)

Neurotoxicity

Study results
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study 8 2
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant