Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
203-180-0
CAS no.:
104-15-4
Index number:
016-030-00-2
Molecular formula:
C7H8O3S
SMILES:
CC1=CC=C(C=C1)S(O)(=O)=O
InChI:
InChI=1S/C7H8O3S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H,8,9,10)
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
24
Of which contain:
1 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance causes serious eye irritation, causes skin irritation and may cause respiratory irritation.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance causes severe skin burns and eye damage and causes serious eye damage.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is harmful if swallowed.

Breakdown of all 1862 C&L notifications submitted to ECHA

STOT SE 3 H335 Harmonised Classification
Eye Irrit. 2 H319 Harmonised Classification
Skin Irrit. 2 H315 Harmonised Classification
Eye Dam. 1 H318
Skin Corr. 1C H314
Skin Corr. 1B H314
Acute Tox. 4 H302
STOT SE 3 H370
Met. Corr. 1 H290
Repr. 1B H360F
Skin Corr. 1A H314
Water-react. 1 H260
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 23 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.

This substance is used by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: pH regulators and water treatment products and laboratory chemicals.

This substance is used in the following areas: health services and scientific research and development.

This substance is used in the following activities or processes at workplace: transfer of chemicals, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, laboratory work, transfer of substance into small containers, roller or brushing applications, calendering operations, non-industrial spraying, blowing agents in manufacture of foam, treatment of articles by dipping and pouring, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and lubrication at high energy conditions and in partly open process.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: metal surface treatment products and non-metal-surface treatment products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: coating products, polymers and lubricants and greases.

This substance is used for the manufacture of: chemicals, fabricated metal products, plastic products and machinery and vehicles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: as processing aid, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and as processing aid.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not breathe the dust, fume, gas, mist, vapours or spray; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. If swallowed: rinse mouth. Do not induce vomiting. Immediately call a poison center or doctor/physician. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • ALCOVER QUIMICA S.L., CARRETERA MONTBLANC Km 24 43460 ALCOVER Spain
  • Axcentive SARL, Chemin de Champouse 13320 Bouc Bel Air France
  • Bayer AG, Kaiser-Wilhelm-Allee 1 51373 Leverkusen Germany
  • Bidachem S.p.A., S.S. 11 Padana Superiore No. 8 24040 Fornovo San Giovanni BG Italy
  • CAVENAGHI SPA, via Varese 19 20020 lainate Italy
  • Charles River Laboratories Den Bosch B.V. OR63, Hambakenwetering 7 5231DD 's-Hertogenbosch Netherlands
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Dublin Ireland
  • CU Chemie Uetikon GmbH, Raiffeisenstrasse 4 77933 Lahr Baden-Württemberg Germany
  • Du Pont de Nemours (Deutschland) GmbH, Hugenottenallee 175 D-63263 Neu-Isenburg Hesse Germany
  • Experien Chemical Services (Ireland) Limited, Unit 3D North Point House North Point Business Park, New Mallow Road TS23 AT2P Cork Ireland
  • Gedeon Richter Plc., Gyomroi ut 19-21 1103 Budapest Hungary
  • Habrinol Decin, Tovarni 63 407 11 Decin XXXII Decin Czech Republic
  • Innospec Performance Chemicals France SAS, Zone Industrielle de Han Sur Meuse BP19 55300 Saint-Mihiel France
  • INNOSPEC PERFORMANCE CHEMICALS ITALIA S.r.l., Via Cavour 50 46043 Castiglione delle Stiviere (Mantova) Italy
  • King Industries International, Science Park 402 1098 XH Amsterdam Amsterdam Netherlands
  • Klaus F. Meyer GmbH, Leiblstraße 3 67136 Fussgoenheim Germany
  • Merck Schuchardt OHG, Eduard-Buchner-Str. 85662 Hohenbrunn Germany
  • MHM Holding GmbH, Sonnenallee 1 D-85551 Kirchheim Germany
  • PHARMEGIC HEALTHCARE LIMITED, 6th Floor, Konstitucijos av. 21A, 08130 Vilnius Lithuania Ireland
  • REACHLaw Ltd, Vänrikinkuja 3 JK 21 FI-02600 ESPOO helsinki Finland
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • STEPAN EUROPE SAS OR, chemin Jongkind CS 20127 38341 VOREPPE France
  • TÜV SÜD Industrie Service GmbH (30), Westendstrasse 199 80686 Munich Germany

Substance names and other identifiers

p-Toluenesulfonic acid
Other
p-toluenesulphonic acid (containing a maximum of 5 % H2SO4)
CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
p-toluenesulphonic acid (containing a maximum of 5 % H2SO4)
C&L Inventory
p-toluenesulphonic acid, (containing more than 5 % H2SO4)
CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
Toluene-4-sulphonic acid
EC Inventory
toluene-4-sulphonic acid
REACH pre-registration
acid p-toluensulfonic(continut maxim de 5% H2SO4) (ro)
C&L Inventory
p-toluensulfonrūgštis (sudėtyje turinti maksimaliai 5 % sieros rūgšties) (lt)
C&L Inventory
toluol-4-szulfonsav (kénsav tartalom max. 5%) (hu)
C&L Inventory
4-methyl benzenesulphonic acid
C&L Inventory
4-methylbenzene-1-sulfonic acid
C&L Inventory, Registration dossier, Other
4-methylbenzene-1-sulfonic acid hydrate
Registration dossier
4-Methylbenzenesulfonic acid
C&L Inventory, Registration dossier
4-methylbenzenesulfonic acid hydrate
C&L Inventory
4-methylbenzenesulfonic acid hydrate
Registration dossier
4-Methylbenzenesulfonic acid monohydrate
C&L Inventory
4-Methylbenzolsulfonsäure
C&L Inventory
4-Toluenesulfonic acid monohydrate
C&L Inventory
acide para toluene sulfonique
C&L Inventory
acido 4-metilbenzensulfonico
C&L Inventory
Benzenesulfonic acid, 4-methyl-
C&L Inventory
Benzenesulfonic acid, 4-methyl-, monohydrate
C&L Inventory
p-Toluenesulfonic acid
C&L Inventory
p-Toluenesulfonic acid
Registration dossier
p-Toluenesulfonic Acid Monohydrate
C&L Inventory
p-Toluenesulphonic acid
C&L Inventory
p-Toluenesulphonic acid
C&L Inventory, Registration dossier
p-toluenesulphonic acid (containing a maximum of 5 % H2SO4)
C&L Inventory
p-toluenesulphonic acid hydrate
Registration dossier
p-toluenesulphonic acid, containing a maximum of 5% H2SO4
C&L Inventory
p-Toluensulfonic acid
C&L Inventory
Para Toluene Sulfonic Acid (PTSA)
C&L Inventory
Reaction mass of sulphuric acid and 7732-18-5
C&L Inventory
toluen 4-sulfonová kyselina
Registration dossier
Toluene sulphonic acid
Registration dossier
toluene-4-silphonic acid
C&L Inventory
toluene-4-sulfonic acid
C&L Inventory
TOLUENE-4-SULPHONIC ACID
C&L Inventory, Registration dossier
Toluene-4-sulphonic acid
C&L Inventory, Registration dossier
TOLUENESULFONIC ACID
C&L Inventory
Toluenesulfonic acid, p-
C&L Inventory
Toluol-4-sulfonsäure
C&L Inventory
Toluol-4-sulfonsäure Monohydrat
C&L Inventory
TSA
Registration dossier
ácido 4-metilbenzenosulfónico
C&L Inventory
4-Methylbenzenesulfonic Acid
C&L Inventory
4-Methylbenzolsulfonsaeure, Monohydrat
C&L Inventory
4-Methylbenzolsulfonsäure
C&L Inventory
4-Toluenesulfonic acid
C&L Inventory
Acide benzènesulfonique, 4-méthyl-
C&L Inventory
Acide benzènesulfonique, 4-méthyl- (< 5 % acide sulfurique)
C&L Inventory
Acide toluene-4-sulfonique
C&L Inventory
acido tolueno-4-sulfonico
C&L Inventory
Benzenesulfonic acid, 4-methyl-
C&L Inventory
Benzenesulfonic acid, 4-methyl- (9CI)
C&L Inventory
Benzolsulfonsaeure, 4-methyl
C&L Inventory
Benzolsulfonsäure, 4-Methyl-
C&L Inventory
Cyzac 4040
C&L Inventory
Eltesol TA
C&L Inventory
Eltesol TA 65
C&L Inventory
Eltesol TA/E
C&L Inventory
Eltesol TA/F
C&L Inventory
Eltesol TA/H
C&L Inventory
Eltesol TA/K
C&L Inventory
Eltesol TA96
C&L Inventory
Eltesol TSX
C&L Inventory
Eltesol TSX/A
C&L Inventory
Eltesol TSX/SF
C&L Inventory
K-Cure 1040
C&L Inventory
LAS 4-methyl, p-
C&L Inventory
LAS 4-methyl, p- (max 5 % sulfuric acid); <5% Schwefelsaeure
C&L Inventory
Manro PTSA/95
C&L Inventory
Manro PTSA/C
C&L Inventory
MANRO PTSA/C; 60-100% Active Matter; active substance
C&L Inventory
Manro PTSA/E
C&L Inventory
Manro PTSA/LG
C&L Inventory
Manro PTSA/LS
C&L Inventory
Methylbenzolsulfonsäure, 4-
C&L Inventory
Nacure 1040
C&L Inventory
p-Methylbenzenesulfonic acid
C&L Inventory
p-Methylphenylsulfonic acid
C&L Inventory
p-Toluene sulfonate
C&L Inventory
p-TOLUENE SULFONIC ACID
C&L Inventory
p-Toluene Sulfonic Acid Monohydrat
C&L Inventory
p-Toluenesulfonic acid
C&L Inventory
p-Toluenesulphonic acid
C&L Inventory
p-Toluolsulfonsaeure
C&L Inventory
p-Toluolsulfonsäure
C&L Inventory
p-Toluolsulfonsäure in ca.65%iger wässriger Lsg.; 65% Active Matter; active substance
C&L Inventory
p-Tolylsulfonic acid
C&L Inventory
P.T.S.A
C&L Inventory
PARA-TOLUENESULFONIC ACID CC5U
C&L Inventory
PARATOLUOLSULFONSAEURE
C&L Inventory
PTSA 70
C&L Inventory
Reworyl T 65
C&L Inventory
Stepanate PTSA-C; 60-100% Active Matter; active substance
C&L Inventory
Sulframin TX
C&L Inventory
Toluene Sulfonic Acid
C&L Inventory
Toluene sulfonic acid (INCI)
C&L Inventory
Toluene sulphonic acid (65% in water) TL65LS; 65% Active Matter; active substance
C&L Inventory
toluene-4-sulphonic acid
Registration dossier
Toluenesulfonic acid
C&L Inventory
TOLUENESULFONIC ACID, HI-PARA
C&L Inventory
Toluenesulfonic acid, p-
C&L Inventory
Toluenesulfonic acid, p- 65%; 65% Active Matter; active substance
C&L Inventory
Toluensulfonic acid; 95% Active Matter; active substance
C&L Inventory
Toluol-4-sulfonsaeure
C&L Inventory
Toluol-4-sulfonsäure
C&L Inventory
Toluol-p-sulfonsäure
C&L Inventory
Toluolsulfo säure, p- 65 %; 65% Active Matter; active substance
C&L Inventory
Toluolsulfo säure, para
C&L Inventory
Toluolsulfonic acid, para
C&L Inventory
Tosic acid
C&L Inventory
TSA
Registration dossier
Wilconate TX Acid
C&L Inventory
Witco TX Acid
C&L Inventory
016-030-00-2
Index number
C&L Inventory
100901-72-2
CAS number
Other
1023356-14-0
CAS number
Other
104-15-4
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other
114213-96-6
CAS number
Other
119314-18-0
CAS number
Other
126033-27-0
CAS number
Other
128739-80-0
CAS number
Other
144647-92-7
CAS number
Other
156627-46-2
CAS number
Other
185568-48-3
CAS number
Other
210357-81-6
CAS number
Other
227313-49-7
CAS number
Other
369371-25-5
CAS number
Other
402-47-1
CAS number
Other
51506-29-7
CAS number
Other
613262-31-0
CAS number
Other
6192-52-5
CAS number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 5 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Form
Paste (100%) [1]
C Odour
Odourless (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 5 studies submitted
  • 1 study processed
R Melting / freezing point
30 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
4 °C

Boiling point

Study results
  • 5 studies submitted
  • 2 studies processed
R Boiling point
166.7 - 223.4 °C [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
167 °C

Density

Study results
  • 5 studies submitted
  • 1 study processed
R Relative density
1.345 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.51

Vapour pressure

Study results
  • 10 studies submitted
  • 1 study processed
R Vapour pressure
33 hPa @ 35 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 5 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
69.8 Pa @ 20 °C

Partition coefficient

Study results
  • 6 studies submitted
  • 1 study processed
R Log Pow
-0.96 @ 50 °C and pH 6 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
0.41 @ 25 °C

Water solubility

Study results
  • 5 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
1 154 g/L @ 20 °C and pH 0 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
50 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Surface tension at 20 °C
49 mN/m @ 1 000 mg/L

Flash point

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
104 °C

Auto flammability

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 12 studies submitted
  • 3 studies processed
C Interpretation of results
GHS criteria not met (100%) [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 8
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 5 studies submitted
  • 1 study processed
C Dissociating properties
Not determined (100%) [1]
R Dissociation constant
2.96 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
pKa at 20 °C
2.5

Viscosity

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Static viscosity at 20 °C
166.2 mm²/s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
19.207 days
Degradation rate constant with OH radicals
0 cm³ molecule-1 d-1

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 15 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 6
Weight of evidence 3 2
Other 1 3
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)
Type of water
Freshwater (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in soil
16 days @ 25 °C

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
3.162 L/kg ww

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Adsorption/desorption

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
12.18

Henrys law constant (H)

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 73 µg/L (1)
Intermittent releases (freshwater) 730 µg/L (1)
Marine water 7.3 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 65 mg/L (1)
Sediment (freshwater) 350 µg/kg sediment dw (1)
Sediment (marine water) 35 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 27.5 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 6 studies submitted
  • 1 study processed
P/RResults
LC50 (4 days) 500 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 11 studies submitted
  • 1 study processed
P/RResults
EC50 (24 h) 1 g/L [1]

Type of Study provided
Studies with data
Key study
Supporting study 1 9
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
EC50 (72 h) 252 - 310 mg/L [3]
NOEC (72 h) 40 mg/L [1]
EC10 (72 h) 85 mg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
73 mg/L
EC10 or NOEC for freshwater algae
44.8 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
EC50 (3 h) 1 g/L [1]
EC10 (3 h) 240 - 1 000 mg/L [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
650 mg/L
EC10 or NOEC for microorganisms
156 mg/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 24.7 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (Medium hazard (no threshold derived)) -
Acute /short term: (Medium hazard (no threshold derived)) -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 7 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (Medium hazard (no threshold derived)) -
Acute /short term: Medium hazard (no threshold derived)
EYE Exposure
High hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4.35 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (Medium hazard (no threshold derived)) -
Acute /short term: (Medium hazard (no threshold derived)) -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.5 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.5 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
High hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 10 studies submitted
  • 1 study processed
P/RResults
LD50 1 410 mg/kg bw (rat) [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 9
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 5 studies submitted
  • 4 studies processed
P/RResults
LD50 2 000 mg/kg bw (rabbit) [4]
M/CInterpretations of results
GHS criteria not met [4]

dermal
Studies with data
Key study
Supporting study
Weight of evidence 4
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 1 410 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (corrosive)
Eye
Adverse effect observed (irreversible damage)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 14 studies submitted
  • 3 studies processed
P/RResults
NOAEL (rat): 500 - 1 000 mg/kg bw/day [2]
LOAEL (rat): 250 mg/kg bw/day [1]
NOEL (rat): 100 - 500 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 1 1
Supporting study 11
Weight of evidence 1
Other
Data waiving
no waivers
Study data: inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: dermal
  • 5 studies submitted
  • 4 studies processed
P/RResults
NOAEL (rat): 500 - 1 030 mg/kg bw/day [4]
NOAEL (mouse): 1 600 - 2 000 mg/kg bw/day [2]
NOAEL (mouse): 440 mg/kg bw (total dose) [1]

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence 4
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 250 mg/kg bw/day (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2 1
Supporting study 14
Weight of evidence 1
Other
Data waiving
no waivers
Study data: in vivo
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Dermal route:
No adverse effect observed NOAEL 240 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 500 mg/kg bw/day (subchronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 500 mg/kg bw/day (subchronic, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant