Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
203-466-5
CAS no.:
107-13-1
Index number:
Molecular formula:
C3H3N
SMILES:
C=CC#N
InChI:
InChI=1S/C3H3N/c1-2-3-4/h2H,1H2
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
30
Of which contain:
5 impurities relevant for classification
1 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is toxic if swallowed, is toxic in contact with skin, is toxic if inhaled, may cause cancer, is toxic to aquatic life with long lasting effects, is a highly flammable liquid and vapour, causes serious eye damage, causes skin irritation, may cause an allergic skin reaction and may cause respiratory irritation.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is suspected of causing cancer and is suspected of damaging fertility or the unborn child.

Breakdown of all 925 C&L notifications submitted to ECHA

STOT SE 3 H335 Harmonised Classification
Flam. Liq. 2 H225 Harmonised Classification
Eye Dam. 1 H318 Harmonised Classification
Skin Irrit. 2 H315 Harmonised Classification
Acute Tox. 3 H301 Harmonised Classification
Aquatic Chronic 2 H411 Harmonised Classification
Carc. 1B H350 Harmonised Classification
Acute Tox. 3 H311 Harmonised Classification
Acute Tox. 3 H331 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
Skin Sens. 1B H317
Repr. 2 H361
Acute Tox. 2 H310
Acute Tox. 2 H330
STOT SE 3 H336
https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Harmonised C&L).
  • C
There is broad agreement in that a majority of data submitters agree this substance is Carcinogenic (99.6% of REACH registrations).
  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 123 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 000 000 - 10 000 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: polymers.

Release to the environment of this substance can occur from industrial use: for thermoplastic manufacture. Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance is used in the following activities or processes at workplace: production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: for thermoplastic manufacture. Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance can be found in complex articles, with no release intended: vehicles, electrical batteries and accumulators and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines). This substance can be found in products with material based on: fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), plastic (e.g. food packaging and storage, toys, mobile phones) and rubber (e.g. tyres, shoes, toys).

This substance is used in the following products: laboratory chemicals, extraction agents, photo-chemicals and polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging, building & construction work, health services and scientific research and development. This substance is used for the manufacture of: chemicals, rubber products, plastic products and textile, leather or fur.

This substance is used in the following activities or processes at workplace: laboratory work, closed batch processing in synthesis or formulation, transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, mixing in open batch processes and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), of substances in closed systems with minimal release, formulation of mixtures and in processing aids at industrial sites. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

This substance is used in the following products: textile treatment products and dyes.

This substance is used in the following activities or processes at workplace: transfer of chemicals, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, transfer of substance into small containers, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used for the manufacture of: plastic products, rubber products, chemicals and textile, leather or fur.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, transfer of chemicals, closed batch processing in synthesis or formulation, transfer of substance into small containers and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: for thermoplastic manufacture, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, transfer of chemicals, closed processes with no likelihood of exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; take actions to prevent static discharges; do not breathe the dust, fume, gas, mist, vapours or spray; contaminated work clothing should not be allowed out of the workplace; handle and store under inert gas; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; keep cool; do not get in eyes, on skin, or on clothing; obtain special instructions before use; do not eat, drink or smoke when using this product; use personal protective equipment as required.; avoid release to the environment; use non-sparking tools; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; wear respiratory protection.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. If exposed or concerned: get medical advice/attention. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. In case of fire: Use (measures specified by manufacturer/supplier) for extinction. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. Do not induce vomiting. If on skin: wash with soap and water.

Storage statements

Store this substance locked up; in a well-ventilated place and keeping container tightly closed.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium
  • 3M France SAS, 1 Parvis de l'Innovation CS 20203 95006 Cergy-Pontoise Cedex France
  • 3M Svenska AB, Bollstanaesvaengen 3 19189 Sollentuna Sweden
  • AnQore B.V., Mauritslaan 49 6129 EL Urmond Netherlands
  • ARCHROMA IBÉRICA, S.L., ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain
  • Ascend Performance Materials srpl/bvba, Watson & Crick Hill Park 11, rue Granbonpré - Bâtiment H B-1348 Louvain-la-Neuve Walloon Brabant Belgium
  • Axalta Coating Systems Germany GmbH & Co. KG, Christbusch 25 42285 Wuppertal Germany
  • AZOINTERNATIONAL OU, RAUA 28 10152 TALLINN Estonia
  • B.I.G. - OR634, Technische Schoolstraat 43A 2440 Geel Belgium
  • Basell Service Company B.V. - OR1 - Polymers, Deltseplein 27E 3013 AA Rotterdam Netherlands
  • BASF Polyurethanes GmbH, Elastogranstr. 60 49448 Lemförde Niedersachsen Germany
  • BASF Schwarzheide GmbH, Schipkauer Str. 1 01987 Schwarzheide Brandenburg Germany
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • Becton Dickinson SA, Camino de Valdeoliva, s/n 28750 San Agustin de Guadalix, Madrid Spain
  • Becton Dickinson UK Ltd., 1030 Eskdale Road Winnersh Triangle RG41 5TS Wokingham Berkshire United Kingdom
  • Bluestar Fibres Company Limited, P.O. Box 24 Moody Lane DN31 2SS Grimsby North East Lincolnshire United Kingdom
  • Borchers GmbH-AF, Berghausener Str. 100 40764 Langenfeld Germany
  • BTC Europe GmbH, Rheinpromenade 1 40789 Monheim Germany
  • C.S.B. GmbH, Düsseldorfer Str. 113 47809 Krefeld Germany
  • C.S.B. GmbH 0239, Düsseldorfer Str. 113 47809 Krefeld Germany
  • Caplinq Europe B.V., De Trompet 1126 1967 DA Heemskerk Netherlands
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Cornerstone Chemical Company BV, Beursplein 37 (World Trade Center Office 759) 3001 AA Rotterdam Netherlands
  • COVANCE CLINICAL DEVELOPMENT SA 017, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain
  • Covance Clinical Development SA 129, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5-5 Planta 28050 Madrid Spain
  • Covance Clinical Development SA 155, Parque Empresarial Las Tablas, Edifico 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain
  • COVANCE CLINICAL DEVELOPMENT SA 156, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • Covestro Deutschland AG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro Procurement Services GmbH & Co. KG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Cytec Engineered Materials GmbH in its legal capacity as OR of Cytec Industries Inc., Industriestraße 3 76684 Östringen Germany
  • DOW BENELUX B.V., Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. - OR1, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-10, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW CHEMICAL COMPANY LTD, Diamond House, Lotus Park Kingsbury Crescent Middx UB7 0DQ Staines Middx United Kingdom
  • Dow Silicones Belgium SPRL OR-1, PSRC - rue Jules Bordet Parc industriel C 7180 Seneffe Belgium
  • Dr. Knoell Consult -OR- B3, Dynamostr. 19 68165 Mannheim Germany
  • Dralon GmbH, Chempark Dormagen 41522 Dormagen Germany
  • DSM Coating Resins B.V., Ceintuurbaan 5 8022 AW Zwolle Netherlands
  • DSM Coating Resins B.V.-OR, Ceintuurbaan 5 8022 AW Zwolle Netherlands
  • Du Pont (U.K.) Limited, London Road 4th Floor, Kings Court SG1 2NG Stevenage Hertfordshire United Kingdom
  • Elementis UK Ltd., Caroline House 55 - 57 High Holborn WC1V 6DX London United Kingdom
  • ELGA EUROPE SRL, Via della Merlata, 8 20014 NERVIANO MILANO Italy
  • European OGD Ltd (OR CPDC), Nortonthorpe Mill Scissett HD8 9HA Huddersfield United Kingdom
  • Evonik Operations GmbH - ME01, Rellinghauser Straße 1-11 45128 Essen Germany
  • Galata Chemicals GmbH, Chemiestrasse 22 68623 Lampertheim 06 Germany
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • Henkel Italia Operations S.r.L., Via Amoretti 78 20157 Mailand Italy
  • HUNTSMAN HOLLAND BV, Merseyweg 10 3197 KG Botlek-Rotterdam Netherlands
  • ICC Industries B.V., Arena Boulevard 61, 4th floor 1101 DL Amsterdam Netherlands
  • Ineos Feluy SPRL (OR ABS), Parc Industriel de Feluy Nord Zone C B-7181 Feluy Belgium
  • INEOS Manufacturing Deutschland GmbH, Alte Strasse 201 50769 Koeln Germany
  • INEOS Nitriles (UK) Ltd (M & I), PO Box 62 Seal Sands TS2 1TX Middlesbrough United Kingdom
  • INEOS Sales (UK) Ltd, Hawkslease Chapel lane SO437FG Lyndhurst Hampshire United Kingdom
  • INEOS Styrolution Belgium, Haven 725, Scheldelaan 600 Scheldelaan 600 2040 Antwerpen 4 Belgium
  • INEOS Styrolution Europe GmbH, Mainzer Landstrasse 50 60325 Frankfurt am Main Germany
  • Innospec Limited (OR1), Innospec Manufacturing Park Oil Sites Road CH65 4EY Ellesmere Port Cheshire United Kingdom
  • Intertek Deutschland GmbH 38, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • ITW Performance Polymers, A Division of ITW Ireland, Bay 150 Shannon Industrial Estate V14 DF82 Shannon Co. Clare Ireland
  • IVICT Europe GmbH, Kennedydamm 19 40476 Düsseldorf Germany
  • JACOBI CARBONS AB, Slojdaregatan 1 393 53 Kalmar Sweden
  • Jindal Films Europe Virton sprl, Zoning Industriel de Latour 6761 VIRTON Belgium
  • Kemira Oyj, Energiakatu 4 P.O.Box 330 FI-00101 HELSINKI Finland
  • KIST Europe Forschungsgesellschaft mbH, Campus E71 66123 Saarbruecken Germany
  • KIST Europe Forschungsgesellschaft mbH, Campus E 71 D-66123 Saarbruecken Germany
  • knoell Germany – OR – A1, Konrad-Zuse-Ring 25 68163 Mannheim Germany
  • Knoell NL_OR_071, Agro Business Park 75 6708PV Wageningen Netherlands
  • Kodak Graphic Communications GmbH, Hedelfinger Str. 60 70327 Stuttgart Germany
  • L'isolante K-Flex S.p.A., Via Leonardo da Vinci, 36 20877 Roncello Monza Brianza Italy
  • Lanxess Deutschland GmbH, Kennedyplatz 1 50569 Köln Germany
  • Lubrizol Advanced Materials Europe B.V.B.A, Nijverheidsstraat 30 2260 Westerlo-Oevel Belgium
  • Lubrizol Deutschland GmbH, Max-Planck-Strasse 6 27721 RITTERHUDE Germany
  • Lubrizol France SAS, 25 Quai de France 76100 ROUEN France
  • Lubrizol Limited, The Knowle, Nether Lane Hazelwwod DE56 4AN Derby Derbyshire United Kingdom
  • LUKOIL Neftohim Burgas AD (LNH Moscow Sar), Western Industrial Zone 8104 Burgas Bulgaria
  • Marubeni Europe plc, 95 Gresham Street EC2V 7AB London United Kingdom
  • MONTEFIBRE HISPANIA S.A., Carretera de Logroño s/n 09200 Miranda de Ebro - Burgos Castilla y Leon Spain
  • NAM & NAM Europe GmbH, Emil-Figge-Str. 80 44227 Dortmund(028) Germany
  • NAM&NAM Europe GmbH, Emil-Figge-Str.80 44227 Dortmund Germany
  • OIL LOGISTIC LTD., Bauskas iela 58A-7 LV-1004 Riga Latvia
  • OMNOVA Solutions SAS (OR of Eliokem India PVT Ltd), 14 avenue des Tropiques ZA de Courtaboeuf 2, Villejust 91955 Courtaboeuf Cedex France
  • Penman Consulting bvba 09, Avenue des Arts 10 B-1210 Brussels Belgium
  • PETROCHINA INTERNATIONAL (LONDON) CO., LTD, 11th Floor, The Adelphi, 1-11 John Adam Street, WC2N 6HT LONDON United Kingdom
  • POWER POLYMER PLAST SP Z.O.O.., OFFICE 38, HOUSE85, OLIWSKA ST, GDANSK CITY, 80-842 GDANSK CITY Poland
  • Purolite Ltd., Llantrisant Business Park CF72 8LF Llantrisant Wales United Kingdom
  • REACH GLOBAL SERVICES S.A., Rond Point Schuman, 6 B-1040 Brussels Belgium
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACHLaw Ltd, Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • Resindion S.r.l., Via Roma, 55 20082 Binasco Milano Italy
  • SABIC Innovative Plastics BV, Plasticslaan 1 4612 PX Bergen op Zoom Netherlands Netherlands
  • SABIC Petrochemicals B.V., Europaboulevard 1 6135 LD Sittard Netherlands
  • SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium
  • SGL Carbon Fibers Ltd, Muir of Ord Industrial Estate, Great North Road IV6 7UA, Muir of Ord, Easter Rossshire, United Kingdom
  • SGL COMPOSITES S.A., Apartado 5 2836-908 Lavradio Setúbal Portugal
  • SHOWA DENKO EUROPE GmbH, KONRAD-ZUSE-PLATZ 3 81829 München Germany
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • Sinopec Europa GmbH, Messe Turm, Friedrich-Ebert-Anlage 49 60308 Frankfurt am Main Germany
  • SINOPEC Europa Handels Gmbh, Messe Turm, Friedrich-Ebert-Anlage 49 60308 Frankfurt am Main Germany
  • SNF SA, ZAC de Milieux 42163 Andrézieux France
  • Solenis Netherlands B.V., Fascinatio Boulevard 522 2909 VA CAPELLE A/D IJSSEL Netherlands
  • Stadex Nederland BV as OR for Shandong, Boxbergerweg 119 7431PM Diepenveen Netherlands
  • Stahl Europe B.V., Sluisweg 10 5145PE Waalwijk Noord Brabant Netherlands
  • Synthomer (UK) Limited, Central Road Templefields CM20 2BH Harlow Essex United Kingdom
  • T-NET International (EU) GmbH, Rurtal Str. 33 41849 Wassenberg NRW Germany
  • Total Polymer Solutions Ltd, Unit 5 Block 613 Jordanstown Road, Greenogue Business Park Co Rathcoole Dublin Ireland
  • Trinseo Netherlands B.V., Herbert H. Dowweg 5 4542 NM Hoek Netherlands
  • Trinseo Netherlands B.V. OR-4, H.H. Dowweg 5 4542 NM Hoek Netherlands
  • TSGE_9-17, Concordia House, St. James Business Park Grimbald Crag Court HG5 8QB Knaresborough United Kingdom
  • TÜV SÜD Iberia S.A.U. (052), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • Yordas Limited, Lancaster Environment Centre Lancaster University LA1 4YQ Lancaster United Kingdom
  • Zeon Europe GmbH, Hansaallee 249 40549 Düsseldorf NRW Germany
  • [Confidential], [Confidential]
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • ExxonMobil Chemical Films Europe Inc, Zoning Industriel de Latour 6761 Virton Belgium
  • Henkel AG & Co. KGaA, Henkelstrasse 67 40191 Duesseldorf North-Rhine Westfalia Germany
  • Henkel Nederland B.V., Brugwal 11 3432 NZ Nieuwegein Netherlands
  • REACH COMPLIANCE SERVICES LIMITED, 306 The Capel Building, Mary's Abbey, Dublin 7, Ireland Dublin 7 Dublin Ireland
  • REACHLaw Ltd, Vänrikinkuja 3 JK 21 FI-02600 Espoo Finland
  • SABIC Innovative Plastics Espana ScpA, Ctra. Cartagena-Alhama de Murcia km. 13. La Aljorra 30390 Cartagena Spain Spain

Substance names and other identifiers

ACRYLONITRILE, STABILIZED
EU. ADN Dangerous Goods Lists, Directive 2008/68/EC, EU. ADR Dangerous Goods Lists, Directive 2008/68/EC, EU. RID Dangerous Goods Lists, Directive 2008/68/EC
acrilonitril (ro)
C&L Inventory
acrilonitrile (it)
C&L Inventory
acrilonitrilo (es)
C&L Inventory
Acrylnitril (de)
C&L Inventory
acrylonitril (da)
C&L Inventory
acrylonitrile (fr)
C&L Inventory
akrilnitril (hu)
C&L Inventory
akrilnitrilas (lt)
C&L Inventory
akrilnitrils (lv)
C&L Inventory
akrilonitril (hr)
C&L Inventory
akrylnitril (no)
C&L Inventory
akrylonitril (cs)
C&L Inventory
akrylonitryl (pl)
C&L Inventory
Akryylinitriili (fi)
C&L Inventory
Akrülonitriil (et)
C&L Inventory
cyjanek winylu (pl)
C&L Inventory
nitryl kwasu akrylowego (pl)
C&L Inventory
ακρυλονιτρίλιο (el)
C&L Inventory
акрилонитрил (bg)
C&L Inventory
2-Propenenitrile
Other
Acrylonitrile (stabilized with MEHQ)
C&L Inventory
Acrylonitrile, 2-Propenenitrile
Registration dossier
cianuro de vinilo
C&L Inventory
prop-2-enenitrile
C&L Inventory, Registration dossier, Other
Vinyl cyanide
Registration dossier
2-Propenenitrile (9CI)
Registration dossier
ACN
Registration dossier
Acrylic acid nitrile
Registration dossier
Acrylic acid nitrile technical
Registration dossier
Acrylnitril stab. mit MHQ
Registration dossier
Acrylon
Registration dossier
Acrylonitrile (8CI)
Registration dossier
Acrylonitrile technical
Registration dossier
AN
Registration dossier
AN (Acrylonitrile)
Registration dossier
AS Resins
Registration dossier
Barex
Registration dossier
Carbacryl
Registration dossier
Carbacyl
Registration dossier
Cyanoethene
Registration dossier
Cyanoethylene
Registration dossier
Fumigrain
Registration dossier
HF-0660I
Registration dossier
HG-0760AT
Registration dossier
HG-0760GP
Registration dossier
HG-0760TV
Registration dossier
MP-0160 R
Registration dossier
Polymers derived from acrylonitrile
Registration dossier
Propenenitrile
Registration dossier
QU-0191 S
Registration dossier
SD-0150
Registration dossier
SD-0150 U
Registration dossier
SD-0150 W
Registration dossier
SD-0150GP
Registration dossier
VCN
Registration dossier
VE-0812
Registration dossier
VE-0856
Registration dossier
VE-0856 U
Registration dossier
VE-0858
Registration dossier
VE-0860
Registration dossier
VE-0860EX
Registration dossier
Ventox
Registration dossier
VH-0800
Registration dossier
VH-0800 E
Registration dossier
VH-0810
Registration dossier
VH-0815
Registration dossier
Vinylcyanide
Registration dossier
1006710-56-0
CAS number
Other
107-13-1
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, EU. Worker Protection-Hazardous (98/24), EU. Cosmetics Regulation, Annex II, Prohibited Substances, EU. Dangerous Substances - Eco-Labels, EU. ADN Dangerous Goods Lists, Directive 2008/68/EC, EU. ADR Dangerous Goods Lists, Directive 2008/68/EC, EU. RID Dangerous Goods Lists, Directive 2008/68/EC, EU. Com. Reg. No 10/2011 on plastic materials in contact with food, EU. Pregnant Women Protection (92/85), EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Carcinogens/Mutagens Directive (2004/37), EU. Young People at Work (94/33)
1197872-06-2
CAS number
Other
1221168-60-0
CAS number
Other
1309882-90-3
CAS number
Other
1538611-90-3
CAS number
Other
2015239-29-7
CAS number
Other
29754-21-0
CAS number
Other
608-003-00-4
Index number
C&L Inventory
63908-52-1
CAS number
Other
769126-92-3
CAS number
Other
769134-66-9
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [2]
C Form
Liquid (100%) [2]
C Odour
Pungent (100%) [2]
C Substance type
Organic (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 2 studies submitted
  • 2 studies processed
R Melting / freezing point
-83.5 °C @ 101.3 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
-83.5 °C

Boiling point

Study results
  • 2 studies submitted
  • 2 studies processed
R Boiling point
77.3 °C @ 101.3 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
77.3 °C

Density

Study results
  • 4 studies submitted
  • 4 studies processed
R Density
0.8 - 0.81 g/cm³ @ 20 - 25 °C [4]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
806

Vapour pressure

Study results
  • 4 studies submitted
  • 4 studies processed
R Vapour pressure
11.5 - 13.33 kPa @ 20 - 23.6 °C [4]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
11.5 kPa @ 19.85 °C

Partition coefficient

Study results
  • 6 studies submitted
  • 2 studies processed
R Pow
1.02 - 1.05 @ 21 °C and pH 7.6 - 8.5 [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
0.017 @ 21 °C

Water solubility

Study results
  • 2 studies submitted
  • 2 studies processed
R Water solubility (vol%)
7.3 vol% @ 20 °C and pH 7 [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
73 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 2 studies submitted
  • 2 studies processed
R Flash point
0 °C @ 101.3 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flash point at 101 325 Pa
0 °C

Auto flammability

Study results
  • 2 studies submitted
  • 2 studies processed
R Autoflammability / self-ignition
481 °C @ 101.3 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Autoflammability / self-ignition at 101 325 Pa
481 °C

Flammability

Study results
  • 8 studies submitted
  • 2 studies processed
C Interpretation of results
GHS criteria not met (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 6
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oxidising
Non oxidising (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 2 studies submitted
  • 2 studies processed
R dynamic viscosity (in mPa s)
0.34 [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Dynamic viscosity at 20 °C
0.34 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 2 studies submitted
  • 2 studies processed
R Dissipation half life (DT50)
4.1 - 115 days [6]
R Degradation rate constant (OH radicals)
0 - 0 cm³ molecule-1 d-1 [4]
R Degradation rate constant (Ozone)
0 - 0 cm³ molecule-1 d-1 [6]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Half life in air
5 days
Degradation rate constant with OH radicals
0 cm³ molecule-1 d-1

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 8 studies submitted
  • 4 studies processed
C Interpretation of results
Inherently biodegradable (50%), Not readily biodegradable (50%) [4]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 2
Other 4
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Inherently biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation Factor (BCF) - dimensionless
1

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Koc at 20°C
9

Henrys law constant (H)

Study results
  • 2 studies submitted
  • 2 studies processed
R H - (pressure) m³/mol
9.6 Pa m³/mol [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Henry's law constant
9.6 Pa.m³.mol-1

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 17 µg/L (2)
Intermittent releases (freshwater) -
Marine water 17 µg/L (2)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 5 mg/L (2)
Sediment (freshwater) 18.8 µg/kg sediment dw (2)
Sediment (marine water) No hazard identified (2)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil 2.68 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 8 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 5.1 mg/L [2]
LC50 (72 h) 6.2 mg/L [2]
LC50 (48 h) 8.9 mg/L [2]
LC50 (24 h) 12 mg/L [2]
LC0 (4 days) 3.7 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 4 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
LC50 for freshwater fish
5.1 mg/L
LC50 for marine water fish
8.6 mg/L

Long–term toxicity to fish

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
NOEC (30 days) 170 µg/L [2]
LOEC (30 days) 340 µg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 / LC10 or NOEC for freshwater fish
170 µg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 4 studies processed
P/RResults
EC50 (48 h) 2.5 - 22 mg/L [6]
EC50 (24 h) 8.8 mg/L [2]
EC100 (48 h) 100 µg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 / LC50 for freshwater invertebrates
2.5 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 500 - 2 000 µg/L [4]
LOEC (21 days) 1 - 4 mg/L [4]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 / LC10 or NOEC for freshwater invertebrates
500 µg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
EC50 (72 h) 10 mg/L [2]
NOEC (72 h) 950 µg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
10 mg/L
EC10 or NOEC for freshwater algae
950 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 or NOEC for microorganisms
50 mg/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 1
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 2
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (High hazard (no threshold derived)) -
Acute /short term: (Medium hazard (no threshold derived)) -
Local Effects
Long-term: (DNEL) 1.8 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 10 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.4 mg/kg bw/day neurotoxicity
Acute /short term: (Medium hazard (no threshold derived)) -
Local Effects
Long-term: (Medium hazard (no threshold derived)) -
Acute /short term: (Medium hazard (no threshold derived)) -
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 100 µg/m³ carcinogenicity
Acute /short term: (Medium hazard (no threshold derived)) -
Local Effects
Long-term: (DNEL) 60 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 1 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 9 µg/kg bw/day carcinogenicity
Acute /short term: (Medium hazard (no threshold derived)) -
Local Effects
Long-term: (Medium hazard (no threshold derived)) -
Acute /short term: (Medium hazard (no threshold derived)) -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 9 µg/kg bw/day carcinogenicity
Acute /short term: Medium hazard (no threshold derived)
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 22 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence 12 10
Other
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 100 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 8 studies submitted
  • 2 studies processed
P/RResults
LD50 95.1 mg/kg bw (rat) [2]
M/CInterpretations of results
Category 3 based on GHS criteria [2]

Type of Study provided
oral
Studies with data
Key study 2
Supporting study 2 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
inhalation
  • 12 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 h) 920 - 964 ppm (rat) [6]
M/CInterpretations of results
Category 3 based on GHS criteria [2]

inhalation
Studies with data
Key study 2
Supporting study 6 4
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 10 studies submitted
  • 2 studies processed
P/RResults
LD50 200 mg/kg bw (rat) [2]
M/CInterpretations of results
Category 4 based on GHS criteria [2]

dermal
Studies with data
Key study 2
Supporting study 2 6
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
Adverse effect observed LD50 81 mg/kg bw
Inhalation route:
Adverse effect observed LC50 2 050 mg/m³
Dermal route:
Adverse effect observed LD50 200 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 3
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: eye
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 2
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irreversible damage)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 12 studies submitted
  • 8 studies processed
P/RResults
NOAEL (rat): 0.25 - 4.4 mg/kg bw/day [8]
NOAEL (mouse): 5 - 12 mg/kg bw/day [4]
LOAEL (rat): 0.84 - 4.4 mg/kg bw/day [8]
LOAEL (mouse): 12 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study 2 2
Weight of evidence 8
Other
Data waiving
no waivers
Study data: inhalation
  • 10 studies submitted
  • 2 studies processed
P/RResults
NOAEC (rat): 5 ppm [2]
LOAEC (rat): 5 ppm [2]

Study data: inhalation
Studies with data
Key study 2
Supporting study 8
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 250 µg/kg bw/day (chronic, rat)
Inhalation route - systemic effects:
Adverse effect observed LOAEC 11 mg/m³ (subchronic, rat)
Inhalation route - local effects:
Adverse effect observed LOAEC 11 mg/m³ (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 27 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 6
Supporting study 4 17
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 27 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study 2 3
Weight of evidence 16 6
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Toxicity - InVitro
Adverse effect observed (positive)

Carcinogenicity

Study results
  • 22 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 12 2
Weight of evidence 6
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Inhalation route:
Adverse effect observed LOAEC 20 mg/m³ (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2
Supporting study 4 2
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 15 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 4
Supporting study 8 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: other studies
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study 2
Weight of evidence 2
Other 4
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 35 mg/kg bw/day (subchronic, rat)
Inhalation route:
No adverse effect observed NOAEC 211 mg/m³ (subchronic, rat)
Effect on developmental toxicity
Oral route:
Adverse effect observed NOAEL 25 mg/kg bw/day (subacute, rat)
Inhalation route:
No adverse effect observed NOAEC 40 mg/m³ (subacute, rat)

Neurotoxicity

Study results
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 8 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
Adverse effect observed NOAEL 25 mg/kg bw/day (subchronic, rat)
Inhalation route:
Adverse effect observed LOAEC 58.4 mg/m³ (chronic, rat)

Immunotoxicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant