Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
203-625-9
CAS no.:
108-88-3
Index number:
Molecular formula:
C7H8
SMILES:
CC1=CC=CC=C1
InChI:
InChI=1S/C7H8/c1-7-5-3-2-4-6-7/h2-6H,1H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
41
Of which contain:
18 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance may be fatal if swallowed and enters airways, is a highly flammable liquid and vapour, is suspected of damaging the unborn child, may cause damage to organs through prolonged or repeated exposure, causes skin irritation and may cause drowsiness or dizziness.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is suspected of damaging fertility or the unborn child, is harmful to aquatic life with long lasting effects and causes serious eye irritation.

Breakdown of all 7861 C&L notifications submitted to ECHA

Asp. Tox. 1 H304 Harmonised Classification
Flam. Liq. 2 H225 Harmonised Classification
Skin Irrit. 2 H315 Harmonised Classification
STOT RE 2 H373 Harmonised Classification
Repr. 2 H361d Harmonised Classification
STOT SE 3 H336 Harmonised Classification
Aquatic Chronic 3 H412
Eye Irrit. 2 H319
Aquatic Chronic 2 H411
Flam. Liq. 3 H226
STOT SE 3 H335
STOT SE 3 H371
Repr. 1A H360
STOT RE 1 H372
Acute Tox. 4 H302
https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://chesar.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • R
Suspected to be Toxic to Reproduction (Harmonised C&L).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 130 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):
Some uses of this substance are restricted under Annex XVII of REACH.

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 000 000 - 10 000 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: lubricants and greases, polishes and waxes, non-metal-surface treatment products, inks and toners, biocides (e.g. disinfectants, pest control products), textile treatment products and dyes, anti-freeze products, leather treatment products, adhesives and sealants and fuels.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles and treatment of articles by dipping and pouring.

Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance can be found in complex articles, with no release intended: vehicles, machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines) and Vehicles (e.g. personal vehicles, delivery vans, boats, trains, metro or planes)). This substance can be found in products with material based on: metal (e.g. cutlery, pots, toys, jewellery), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper) and plastic (e.g. food packaging and storage, toys, mobile phones).

This substance is used in the following products: coating products, adhesives and sealants, fuels, fillers, putties, plasters, modelling clay and washing & cleaning products.

This substance is used in the following areas: building & construction work. This substance is used for the manufacture of: machinery and vehicles and chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, roller or brushing applications, non-industrial spraying, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and treatment of articles by dipping and pouring.

Other release to the environment of this substance is likely to occur from: outdoor use, indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following products: coating products, polymers, adhesives and sealants, fuels and non-metal-surface treatment products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, laboratory work, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and in processing aids at industrial sites.

This substance is used in the following products: coating products, adhesives and sealants, polymers, non-metal-surface treatment products, inks and toners, lubricants and greases and fuels. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid and formulation of mixtures.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites and of substances in closed systems with minimal release.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; take actions to prevent static discharges; do not breathe the dust, fume, gas, mist, vapours or spray; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; avoid release to the environment; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. If exposed or concerned: get medical advice/attention. If skin irritation occurs: Get medical advice/attention. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. If eye irritation persists get medical advice/attention. Do not induce vomiting.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium
  • AKZO Nobel Car Refinishes B.V., Rijksstraatweg 31 2170 BA Sassenheim Netherlands
  • ALBEMARLE EUROPE SPRL, Parc Scientifique (Einstein) Rue du Bosquet 9 1348 LOUVAIN-LA-NEUVE Belgium
  • AlzChem Trostberg GmbH, Dr.-Albert-Frank-Straße 32 83308 Trostberg Bayern Germany
  • Arsol Aromatics GmbH & Co. KG, Uferstr. 105 45881 Gelsenkirchen Germany
  • AS Novotrade Invest, Keemia 2C-1 30328 Kohtla-Jarve Ida-Virumaa Estonia
  • Ashland Services BV (0311), Noordweg 9 3336 LH Zwijndrecht Netherlands
  • Avantor Performance Materials Poland S.A., Sowińskiego 11 44-100 Gliwice Poland
  • Avery Dennison Materials Europe BV, Willem Einthovenstraat 11 2342 BH Oegstgeest Zuid-Holland Netherlands
  • Baker Hughes Ltd, The Ark, 201 Talgarth Road Hammersmith W6 8BJ London United Kingdom
  • BASF Schwarzheide GmbH, Schipkauer Str. 1 01987 Schwarzheide Brandenburg Germany
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • Belgium Marketing Services N.V., Britselei 23 - box 201 2000 Antwerpen België Belgium
  • Boeing Distribution, Inc. (d/b/a Aviall), Schillingweg 40 2153PL Nieuw-Vennep Noord-Holland Netherlands
  • Braskem Netherlands B.V., Weena 00240, C 9th floor NL - 3012 NJ PO Box 30128 3001 DC Rotterdam Netherlands
  • Brenntag Holding GmbH , Messeallee 11 45131 Essen Germany
  • C.S.B. GmbH, Duesseldorfer Str.113 47809 Krefeld Germany
  • C.S.B. GmbH, Düsseldorfer Strasse 113 47809 Krefeld Germany
  • Chemical Standards SIA, Ritausma 31 LV-2127 Medemciems Olaine parish Latvia
  • Chemservice GmbH - (T6W5), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • Chevron Oronite SA M/I, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • Chevron Phillips Chemicals International NV, Airport Plaza, Stockholm Building, Da Vincilaan 19 B-1831 DIEGEM Belgium
  • COMPANÍA ESPAÑOLA DE PETRÓLEOS, S.A.U. (CEPSA), Torre Cepsa, Paseo de la Castellana 259A 28046 Madrid Spain
  • COVANCE CRS SA 075, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • Covestro Deutschland AG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • CRAY VALLEY SA OR8, 2 Place Jean Millier 92400 Courbevoie France
  • Cytec Industries B.V. OR, Burgemeester van Lierplein 75 3134 ZB Vlaardingen Netherlands
  • DEZA a.s., Masarykova 753 75701 Valasske Mezirici Czech Republic
  • DKSH GmbH, Baumwall 3 20459 Hamburg Germany
  • DKSH Great Britain Ltd., 3 London Bridge Street 3rd Floor, News Building SE1 9SG London United Kingdom
  • DOW BENELUX B.V. OR-10, Postbus 48 4530 AA Terneuzen Netherlands
  • Dow Silicones Belgium SPRL OR-1, PSRC - rue Jules Bordet Parc industriel C 7180 Seneffe Belgium
  • DuPont Solutions (France) SAS, Saint Quentin en Yvelines 78180 Paris France
  • ELGA EUROPE SRL, Via della Merlata, 8 20014 NERVIANO MILANO Italy
  • ELKEM SILICONES FRANCE S.A.S., Immeuble DANICA 21, Avenue Georges Pompidou 69003 Lyon France
  • Essar Oil (UK) Limited, Stanlow Manufacturing Complex PO Box 3 CH65 4HB Ellesmere Port Cheshire United Kingdom
  • Evonik Performance Materials GmbH, Rellinghauser Strasse 1-11 45128 Essen Germany
  • ExponentOR28, The Lenz Hornbeam Business Park HG28RE Harrogate Yorkshire United Kingdom
  • ExxonMobil Chemical Holland B.V., Botlekweg, 121, Haven nr 40-60 NL 3197 KA Botlek Rotterdam Netherlands
  • ExxonMobil Petroleum & Chemical, BVBA, Polderdijkweg 2030 Antwerpen Belgium
  • FLEXcon Europe Ltd., Whitworth Road Southfield Ind. Est. KY6 2TF Glenrothes United Kingdom
  • Glencore Energy UK Ltd, 50 Berkeley Street W1J 8HD London United Kingdom
  • GRACE Catalyst AB, Industrivägen 44432 Stenungsund Sweden
  • GRACE GmbH, In der Hollerhecke 1 67545 Worms Germany
  • GRACE GmbH (OR1), In der Hollerhecke 1 67547 Worms Germany
  • Hartree Partners (UK) Limited, 33 Grosvenor Place SW1X7HY London United Kingdom
  • Henkel AG & Co. KGaA - Only Representative HCorpUSA, Henkelstrasse 67 40191 Duesseldorf Germany
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • HH Compliance Ltd., The Rubicon Centre, CIT Campus, 0000 Bishopstown, Cork Ireland
  • ICC Industries B.V., Arena Boulevard 61, 4th floor 1101 DL Amsterdam Netherlands
  • INEOS Chemicals Lavera (O Imports), Rue de la Bienfaisance 13117 Lavera France
  • INEOS Manufacturing Deutschland GmbH, Alte Strasse 201 50769 Koeln Germany
  • INEOS Styrenics GmbH, Paul-Baumann-Strasse 1 D-45764 Marl Germany
  • INEOS Styrolution Belgium, Haven 725, Scheldelaan 600 Scheldelaan 600 2040 Antwerpen 4 Belgium
  • Innospec Limited (OR1), Innospec Manufacturing Park Oil Sites Road CH65 4EY Ellesmere Port Cheshire United Kingdom
  • Intertek Deutschland GmbH 6, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Semko Service, Box 1103 Torshamnsgatan 43 SE-16440 Kista Stockholm Sweden
  • ITW Performance Polymers, A Division of ITW Ireland, Bay 150 Shannon Industrial Estate V14 DF82 Shannon Co. Clare Ireland
  • knoell Germany – OR – A1, Konrad-Zuse-Ring 25 68163 Mannheim Germany
  • LAS Aerospace, Okehampton Point Exeter Road Industrial Estate EX20 1UA Okehampton Devon United Kingdom
  • Livchem Logistics GmbH, Fritz-Klatte-Strasse 8 D-65933 Frankfurt Germany
  • LORD Germany GMBH, Ottostrasse 28 41836 Hueckelhoven North Rhine - Westphalia Germany
  • Lubrizol Advanced Materials Europe B.V.B.A, Nijverheidsstraat 30 2260 Westerlo-Oevel Belgium
  • Lubrizol France SAS, 25 Quai de France 76100 ROUEN France
  • Lubrizol Limited, The Knowle, Nether Lane Hazelwwod DE56 4AN Derby Derbyshire United Kingdom
  • Marubeni Europe plc, 95 Gresham Street EC2V 7AB London United Kingdom
  • MOL Hungarian Oil and Gas Public Limited Company, Oktober huszonharmadika 18 1117 Budapest Hungary
  • Momentive Performance Materials GmbH, Chempark Building V7 51368 Leverkusen NRW Germany
  • Morgan Stanley & Co. international Plc, 25 Cabot square E14 4QA London United Kingdom
  • Nalco Limited, P.O. Box 11, Winnington Avenue, CW8 4DX Northwich, Cheshire United Kingdom
  • Nouryon Functional Chemicals B.V., Velperweg 76 6824 BM Arnhem Netherlands
  • NP Automotive Coating (Europe) Ltd, Britannia Park Radway Road SN3 4ND Swindon Wiltshire United Kingdom
  • OMV PETROM S.A., 22 Coralilor Street (“Petrom City”) Sector 1 013329 Bucharest Romania
  • OQEMA Contract GmbH, OR1, Nauheimer Strasse 37 70372 Stuttgart Germany
  • PCK RAFFINERIE GMBH, Passower Chaussee 111 16303 Schwedt/Oder Germany
  • Petrochemia-Blachownia S.A., Szkolna 15 47-225 Kędzierzyn - Koźle Poland
  • Petrochemical Commercial Company (UK) Ltd, 24, GROSVENOR GARDENS SW1W 0DH LONDON EUROPE United Kingdom
  • PETROCHINA INTERNATIONAL (LONDON) CO., LTD, 11th Floor, The Adelphi, 1-11 John Adam Street, WC2N 6HT LONDON United Kingdom
  • Petróleos de Portugal - Petrogal, S.A., Rua Tomás da Fonseca, Torres de Lisboa 1600-209 Lisboa Portugal
  • Polski Koncern Naftowy ORLEN SA, ul. Chemików 7 09-411 Płock Poland
  • PPG Europe B.V. - OR1, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. - OR3, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. in its legal capacity as Only Representative of PRC DeSoto International Inc. - OR5, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Industries Italia Srl Società soggetta a direzione e coordinamento da parte di PPG Industries Inc., Via Serra, 1 15028 Quattordio Italy
  • PPG Kansai Automotive Finishes France SAS, Les Dix Muids 59583 Marly France
  • Quaker Chemical B.V., Industrieweg 7 1422 AH Uithoorn Netherlands
  • Raffinerie Heide GmbH, Meldorfer Straße 43 25770 Hemmingstedt Germany
  • RAIN CARBON BVBA, Vredekaai 18 9060 Zelzate Belgium
  • REACHLaw Ltd, Vänrikinkuja 3 JK 21 FI-02600 Espoo Finland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 FI-02600 Espoo Finland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21, FI-02600 Espoo Finland Finland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • Repsol Petroleo, S.A., Calle Mendez Alvaro, 44 28045 Madrid Madrid Spain
  • Ricardo-AEA, Shoreham Technical Centre Old Shoreham Road BN43 8FG Shoreham by Sea West Sussex United Kingdom
  • Ruhr Oel GmbH, Pawiker Strasse 30 45896 Gelsenkirchen Germany
  • sanofi chimie, 82 avenue Raspail 94250 Gentilly France
  • Shell Chemicals Europe B.V., Weena 70 3012 CM Rotterdam Netherlands
  • Shell Deutschland Oil GmbH, Suhrenkamp 71-77, 22335 Hamburg Germany
  • Shell Trading International Ltd, Shell Centre SE1 7NA London United Kingdom
  • Shell Trading Rotterdam B. V., Weena 70 3012 CM Rotterdam Netherlands
  • Shepherd Europe SARL FO, 275, rue de Lorraine 88500 Juvaincourt France
  • Shin-Etsu Silicones Europe BV, Bolderweg 32 1332 AV Almere Netherlands
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • SLOVNAFT, a.s., Vlcie hrdlo 1 824 12 Bratislava Slovakia
  • Specialty Electronic Materials Netherlands B.V. OR-2, Herbert H. Dowweg 5 4542NM Hoek Netherlands
  • Specialty Products Poland sp. z o.o., ul. Postępu 17B 02-676 Warsaw Poland
  • StonCor Europe, Rue du Travail, 9 1400 Nivelles Belgium
  • Synthos Dwory 7 spółka z ograniczoną odpowiedzialnością spółka jawna, ul. Chemików 1 32-600 Oświęcim Poland
  • SYNTHOS Kralupy a.s., O.Wichterleho 810 27801 Kralupy nad Vltavou Czech Republic
  • TELENE SAS, 2 rue Marie Curie 59910 BONDUES Nord-Pas de Calais France
  • The Valspar Corporation (UK) Ltd, Avenue 1, Station Lane OX28 4XR Witney Oxon United Kingdom
  • THREE BOND EUROPE, 26 avenue des bethunes 95310 SAINT OUEN L'AUMONE France
  • TOKUYAMA EUROPE GMBH, Am Gierath 20A 40885 Ratingen Germany
  • Total Olefins Antwerp, Scheldelaan 10 2030 Antwerpen Belgium
  • Total Raffinage France, 2, place Jean Millier, La Défense 92400 Courbevoie France
  • Toyota Tsusho Europe S.A., Belgicastraat 13 1930 Zaventem Belgium
  • TramacoGmbH, Lise-Meitner-Allee 8 25411 Tornesch Germany
  • TÜV SÜD Iberia S.A.U. (054), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • TÜV SÜD Industrie Service GmbH, IS-USR-MUC Westendstraße 199 80686 Munich Germany
  • Valspar b.v., Zuiveringweg 89 8243 PE Lelystad Netherlands
  • versalis S.p.A., P.zza Boldrini 1 20097 San Donato Milanese MILANO Italy
  • Vertellus Specialties UK Ltd, Seal Sands Road Seal Sands TS2 1UB Middlesbrough Cleveland United Kingdom
  • Vitol Chemicals BV, K.P. van der Mandelelaan 130 3062 MB Rotterdam Netherlands
  • WISTEMA GmbH, Industriestraße 2a 69234 Dielheim Germany
  • Yordas GmbH, Äußere Nürnberger Str. 6 91301 Forchheim Germany
  • [Confidential], [Confidential]
  • Arcerion GmbH, Gabrielenstr. 15 80636 Muenchen Germany
  • HML Europe BV, De Haal 82 1511 AT Oostzaan Netherlands
  • Honeywell Specialty Chemicals Seelze GmbH, Wunstorfer Strasse 40 D-30926 Seelze Lower Saxony Germany
  • Interchem Logistics B.V., Javastraat 4 3016 CE Rotterdam Netherlands
  • OLTCHIM SA, Uzinei 1 240050 Ramnicu Valcea Valcea Romania
  • PETROBRAS EUROPE LIMITED., 9th Floor, 1 Angel Court EC2R 7HJ London United Kingdom
  • PETROBRAS GLOBAL TRADING BV - PGT BV, Weena 762 - 9th Floor, First Rotterdam 3014 DA Rotterdam Netherlands
  • The Acta Group EU, Ltd (21), Brook House Suite 2B M2 2BQ Manchester United Kingdom
  • Total Petrochemicals France SA, Immeuble Le Linéa 1, rue du Général Leclerc 92047 Paris La Défence Cedex France
  • VPR Energy BV, Neckarweg 5 Haven 5526 3198 Rotterdam Netherlands

Substance names and other identifiers

metylobenzen (pl)
C&L Inventory
tolueen (et)
C&L Inventory
Tolueeni (fi)
C&L Inventory
toluen (cs)
C&L Inventory
toluenas (lt)
C&L Inventory
toluene (it)
C&L Inventory
tolueno (es)
C&L Inventory
Toluol (de)
C&L Inventory
toluols (lv)
C&L Inventory
toluène (fr)
C&L Inventory
toluén (sk)
C&L Inventory
τολουόλιο (el)
C&L Inventory
толуен (bg)
C&L Inventory
Benzene, methyl-
Other
1-Methylbenzene
C&L Inventory
ARON S-1030C
C&L Inventory
Benzene, methyl
C&L Inventory
fenilmetano
C&L Inventory
METHYL BENZENE
C&L Inventory
Methylbenzen
C&L Inventory
METHYLBENZENE
C&L Inventory, Registration dossier
Methylbenzol
C&L Inventory
METILBENZENE
C&L Inventory
méthylbenzène
C&L Inventory
Not Applicable
Registration dossier
Phenylmethane
C&L Inventory
Reaction mass of butanone and n-hexane and Naphtha (petroleum), solvent-refined light
C&L Inventory
Toluene (TR0009B)
Registration dossier
Toulene
C&L Inventory
Touol technisch
Registration dossier
Antisal 1a
Registration dossier
Benzene, methyl- (9CI)
Registration dossier
CP 25
Registration dossier
CP 25 (solvent)
Registration dossier
Crosslinker 181 S
Registration dossier
Methacide
Registration dossier
POLYTONE AP 108
Registration dossier
POLYTONE AP 109
Registration dossier
POLYTONE AP 109 D
Registration dossier
POLYTONE AP 110
Registration dossier
POLYTONE AP 111
Registration dossier
POLYTONE AP 111 HM
Registration dossier
POLYTONE AP 112
Registration dossier
POLYTONE AP 112 SR
Registration dossier
POLYTONE AP 114
Registration dossier
POLYTONE AP 120
Registration dossier
POLYTONE AP 130
Registration dossier
Pure Toluene
Registration dossier
Reintoluol
Registration dossier
SS 8010
Registration dossier
Toluene (8CI)
Registration dossier
Toluol technisch
Registration dossier
TSC920
Registration dossier
1053657-77-4
Deleted CAS number
Other
108-88-3
CAS number
EC Inventory, C&L Inventory, Restriction list, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other
1202864-97-8
Deleted CAS number
Other
601-021-00-3
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 3 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 2 studies submitted
  • 1 study processed
R Melting / freezing point
-95 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-95.15 °C

Boiling point

Study results
  • 2 studies submitted
  • 1 study processed
R Boiling point
110.6 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
110.85 °C

Density

Study results
  • 2 studies submitted
  • 1 study processed
R Relative density
0.87 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
866

Vapour pressure

Study results
  • 2 studies submitted
  • 1 study processed
R Vapour pressure
30.889 - 41.3 hPa @ 21.111 - 26.667 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
30.89 hPa @ 21.1 °C

Partition coefficient

Study results
  • 2 studies submitted
  • 1 study processed
R Log Pow
2.73 @ 20 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
2.73 @ 20 °C

Water solubility

Study results
  • 2 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
573 - 587 mg/L @ 25 °C and pH 7 [4]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
587 mg/L @ 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 1 study processed
R Surface tension
27.73 mN/m @ 516 mg/L and 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Surface tension at 20 °C
27.73 mN/m

Flash point

Study results
  • 2 studies submitted
  • 1 study processed
R Flash point
4.4 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
4.45 °C

Auto flammability

Study results
  • 2 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
480 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
479.85 °C

Flammability

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
Highly flammable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 2 studies submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
0.56 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Dynamic viscosity at 20 °C
0.56 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 1 study processed
R Dissipation half life (DT50)
62.16 h [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
62.16 h

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 4 studies submitted
  • 3 studies processed
C Interpretation of results
Readily biodegradable (100%) [3]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
205

Henrys law constant (H)

Study results
  • 2 studies submitted
  • 1 study processed
R H - (pressure) m³/mol
485 Pa m³/mol [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
485 Pa.m³.mol-1 @ 20 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 680 µg/L (1)
Intermittent releases (freshwater) 680 µg/L (1)
Marine water 680 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 13.61 mg/L (1)
Sediment (freshwater) 16.39 mg/kg sediment dw (1)
Sediment (marine water) 16.39 mg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 2.89 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
LC50 (4 days) 5.5 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
5.5 mg/L

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (40 days) 1.39 mg/L [1]
LOEC (40 days) 2.77 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater fish
1.4 mg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
LC50 (48 h) 3.78 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
3.78 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (7 days) 740 µg/L [1]
LOEC (7 days) 2.76 mg/L [1]
EC50 (7 days) 3.23 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
740 µg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EC50 (3 h) 134 - 207 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
134 mg/L
EC10 or NOEC for freshwater algae
10 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (24 h) 84 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
84 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 192 mg/m³ neurotoxicity
Acute /short term: (DNEL) 384 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 192 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 384 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 384 mg/kg bw/day neurotoxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 56.5 mg/m³ neurotoxicity
Acute /short term: (DNEL) 226 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 56.5 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 226 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 226 mg/kg bw/day neurotoxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: Low hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 8.13 mg/kg bw/day neurotoxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 3.6 %
Inhalation: 50 %

Acute toxicity

Study results
oral
  • 2 studies submitted
  • 1 study processed
P/RResults
LD50 5 580 mg/kg bw (rat) [1]
M/CInterpretations of results
Not classified [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 2 studies submitted
  • 1 study processed
P/RResults
LC50 (4 h) 25.7 - 30 mg/L air (rat) [3]
M/CInterpretations of results
Not classified [1]

inhalation
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 1 study submitted
  • 1 study processed
P/RResults
LD50 5 000 mg/kg bw (rabbit) [1]
M/CInterpretations of results
Not classified [1]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 5 000 mg/kg bw
Inhalation route:
No adverse effect observed Discriminating conc. 192 mg/m³
Dermal route:
No adverse effect observed LD50 5 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 625 mg/kg bw/day [1]
NOAEL (mouse): 625 mg/kg bw/day [1]
LOAEL (rat): 1 250 mg/kg bw/day [1]
LOAEL (mouse): 1 250 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 6 studies submitted
  • 3 studies processed
P/RResults
NOAEC (rat): 1.131 - 2.355 mg/L air [2]
NOAEC (rat): 300 - 625 ppm [2]
LOAEC (rat): 2.261 - 4.71 mg/L air [2]
LOAEC (rat): 600 - 1 250 ppm [2]

Study data: inhalation
Studies with data
Key study 3 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 625 mg/kg bw/day (subchronic, rat)
Inhalation route - local effects:
Adverse effect observed LOAEC 2 261 mg/m³ (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: in vivo
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Inhalation route:
No adverse effect observed NOAEC 4 522 mg/m³ (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Study results
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 11
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant