Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
203-806-2
CAS no.:
110-82-7
Index number:
601-017-00-1
Molecular formula:
C6H12
SMILES:
C1CCCCC1
InChI:
InChI=1S/C6H12/c1-2-4-6-5-3-1/h1-6H2
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
21
Of which contain:
10 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance may be fatal if swallowed and enters airways, is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects, is a highly flammable liquid and vapour, causes skin irritation and may cause drowsiness or dizziness.

Breakdown of all 4869 C&L notifications submitted to ECHA

Asp. Tox. 1 H304 Harmonised Classification
Flam. Liq. 2 H225 Harmonised Classification
Aquatic Acute 1 H400 Harmonised Classification
Skin Irrit. 2 H315 Harmonised Classification
STOT SE 3 H336 Harmonised Classification
Aquatic Chronic 1 H410 Harmonised Classification
Aquatic Chronic 3 H412
STOT SE 3 H335
Eye Irrit. 2 H319
Acute Tox. 4 H332
Aquatic Chronic 2 H411
Repr. 2 H361
STOT SE 2 H371
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • PBT
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Persistent, Bioaccumulative and Toxic (1.82% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 49 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):
Some uses of this substance are restricted under Annex XVII of REACH.

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 000 to < 10 000 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: lubricants and greases, fuels, coating products, non-metal-surface treatment products, adhesives and sealants and anti-freeze products.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following activities or processes at workplace: production of mixtures or articles by tabletting, compression, extrusion or pelletisation and the low energy manipulation of substances bound in materials or articles.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: pH regulators and water treatment products, laboratory chemicals and washing & cleaning products.

This substance is used in the following areas: health services and scientific research and development.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure and roller or brushing applications.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following products: polymers, laboratory chemicals and pharmaceuticals. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, transfer of substance into small containers and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials and manufacturing of the substance.

This substance is used in the following products: laboratory chemicals and pH regulators and water treatment products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release, as an intermediate step in further manufacturing of another substance (use of intermediates) and for thermoplastic manufacture.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites and formulation of mixtures.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: keep away from heat, sparks, open flames and/or hot surfaces – No smoking; avoid release to the environment; take actions to prevent static discharges; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. Do not induce vomiting. If skin irritation occurs: Get medical advice/attention. Collect spillage.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL (OR1), Hermeslaan 7 1831 Diegem Belgium
  • ALSACHIMIE, Route départementale 52 68490 Chalampé France
  • AVANTOR PERFORMANCE MATERIALS POLAND SPÓŁKA AKCYJNA, Sowińskiego 11 44-101 Gliwice Silesia Poland
  • BASF Antwerpen N.V., Haven 725, Scheldelaan 600 2040 Antwerpen 4 Antwerpen Belgium
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • BP Europa SE, Überseeallee 1 20457 Hamburg Germany
  • Braskem Netherlands B.V., Weena 00240, C 9th floor NL - 3012 NJ PO Box 30128 3001 DC Rotterdam Netherlands
  • Brenntag Holding GmbH , Messeallee 11 45131 Essen Germany
  • CEPSA Química, S.A., Edificio Torre Picasso Plaza Pablo Ruiz Picasso, 1 28020 Madrid Spain
  • Chemium Iberica, Calle Velazquez 64-66 28001 Madrid Spain
  • Chemservice GmbH - (T6W5), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • Chevron Phillips Chemicals International N.V. - OR CPC, Airport Plaza, Stockholm Building Da Vincilaan 19 1831 Diegem Belgium
  • Chevron Phillips Chemicals International N.V. - OR SCP, Airport Plaza, Stockholm Building Da Vincilaan 19 B - 1831 DIEGEM Belgium
  • COMPANÍA ESPAÑOLA DE PETRÓLEOS, S.A (CEPSA), Torre Cepsa, Paseo de la Castellana 259A 28046 Madrid Spain
  • Count Energy Trading B.V., Waalhaven Oostzijde 77 3087 BM Rotterdam Netherlands
  • Evonik Operations GmbH, Rellinghauser Straße 1-11 45128 Essen Germany
  • ExxonMobil Chemical Holland B.V., Botlekweg, 121, Haven nr 40-60 NL 3197 KA Botlek Rotterdam Netherlands
  • ExxonMobil Petroleum & Chemical BV, Polderdijkweg 2030 Antwerpen Belgium
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17, 22363 Lund Sweden
  • GRACE Catalyst AB, Industrivägen 44432 Stenungsund Sweden
  • GRACE GmbH, In der Hollerhecke 1 67545 Worms Germany
  • GRACE GmbH (OR1), In der Hollerhecke 1 67547 Worms Germany
  • Grupa Azoty S.A., ul. Kwiatkowskiego 8 33-101 Tarnow Poland
  • Grupa Azoty Zakłady Azotowe „Puławy” S.A., al. Tysiąclecia Państwa Polskiego 13 24-110 Puławy Poland
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • Holborn Europa Raffinerie GmbH, Moorburger Strasse 18 21079 Hamburg Germany
  • Honeywell Specialty Chemicals Seelze GmbH, Wunstorfer Str. 40 30926 Seelze Deutschland Germany
  • Intertek Deutschland GmbH 14, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • ITELYUM Purification S.P.A., Via S. Intini n. 2 27015 Landriano (PV) Italy
  • Kolmar NL BV, Claude Debussylaan 10 1082MD Amsterdam Netherlands
  • Koryfes S.A., 76-78 rue de Merl 2146 Luxembourg Luxembourg
  • Lanxess Deutschland GmbH, Kennedyplatz 1 50569 Köln Germany
  • LANXESS Performance Materials N.V., Scheldelaan 420 Haven 507 2040 Antwerpen Belgium
  • Marubeni International (Europe) GmbH, Benrather Str. 18-20 40213 Düsseldorf Germany
  • Penman Consulting bvba 08, Avenue des Arts 10 B-1210 Brussels Belgium
  • PPG Industries Italia Srl Società soggetta a direzione e coordinamento da parte di PPG Industries Inc., Via Serra, 1 15028 Quattordio Italy
  • PPG Kansai Automotive Finishes France SAS, Les Dix Muids 59583 Marly France
  • REACHLaw Ltd., Aleksanterinkatu 19 00100 Helsinki Finland
  • Regartis s.r.o., Rubeška 393/7 19000 Prague 9 Czech Republic
  • Ruhr Oel GmbH, Pawiker Strasse 30 45896 Gelsenkirchen Germany
  • SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium
  • Semperit Technische Produkte Ges. m. b. H. , Modecenterstrasse 22 1030 Wien Austria
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • SIGMA-ALDRICH CHIMIE SARL, 80 Rue de Luzais BP 701 38297 Saint Quentin Fallavier France
  • Sigma-Aldrich Ireland Ltd, Vale Road . Arklow Co. Wicklow Ireland
  • TotalEnergies Trading Europe, 2 Place Jean Millier La Défense 6 92400 Courbevoie France
  • TramacoGmbH, Lise-Meitner-Allee 8 25411 Tornesch Germany
  • UBE Corporation Europe, S.A.U., Poligono Industrial El Serrallo, s/n 12100 Castellón Spain
  • Adriaanse Import & Export, Adriaan Mulderweg 9-11 5657 EM Eindhoven Netherlands
  • ICC Industries B.V., Arena Boulevard 61, 4th floor 1101 DL Amsterdam Netherlands
  • SABIC UK Petrochemicals Limited, Wilton Centre TS10 4RF Redcar Cleveland United Kingdom
  • TotalEnergies Olefins Antwerp, Scheldelaan 10 2030 Antwerpen Belgium
  • Tricon Energy Iberica, S.L.U., Avenida Pau Casals, nº 14, 6º piso, 08021 Barcelona Spain
  • TÜV SÜD Industrie Service GmbH (32), Westendstrasse 199 80686 Munich Germany

Substance names and other identifiers

Benzene, hexahydro-
Other
Benzenehexahydride
Other
Cicloesano
Other
Ciclohexano
Other
Cyclohexaan
Other
Cyclohexan
Other
Cyclohexane
EC Inventory, C&L Inventory, Restriction list, REACH pre-registration, Other, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Occupational Exposure Limits - 2nd list - Indicative OELVs, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Food Contact Regenerated Cellulose Directive - Authorised Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
CYCLOHEXANE
C&L Inventory, Restriction list, REACH pre-registration, Other, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Occupational Exposure Limits - 2nd list - Indicative OELVs, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Food Contact Regenerated Cellulose Directive - Authorised Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
Cykloheksan
Other
Hexahydrobenzene
Other
Hexamethylene
Other
Hexanaphthene
Other
ciclo-hexano (pt)
C&L Inventory
cicloesano (it)
C&L Inventory
ciclohexan (mt)
C&L Inventory
Ciclohexan (ro)
C&L Inventory
ciclohexano (es)
C&L Inventory
cikloheksan (hr)
C&L Inventory
cikloheksan (sl)
C&L Inventory
cikloheksanas (lt)
C&L Inventory
cikloheksāns (lv)
C&L Inventory
ciklohexán (hu)
C&L Inventory
cyclohexaan (nl)
C&L Inventory
cyclohexan (da)
C&L Inventory
Cyclohexan (de)
C&L Inventory
cyclohexane (fr)
C&L Inventory
cykloheksan (no)
C&L Inventory
cykloheksan (pl)
C&L Inventory
cyklohexan (cs)
C&L Inventory
cyklohexan (sv)
C&L Inventory
cyklohexán (sk)
C&L Inventory
Sykloheksaani (fi)
C&L Inventory
Tsükloheksaan (et)
C&L Inventory
κυκλοεξάνιο (el)
C&L Inventory
циклохексан (bg)
C&L Inventory
cyclehexane
C&L Inventory
cyclohaxane
C&L Inventory
Cyclohexan
C&L Inventory
Cyclohexan
Registration dossier
CYCLOHEXANE
C&L Inventory, Registration dossier, Other
Cyclohexane
C&L Inventory, Registration dossier, Other
cyklohexan
C&L Inventory
not applicable
Registration dossier
Reaction mass of 100-41-4 and 1330-20-7 and 141-78-6 and 64-17-5 and 67-63-0 and 68609-36-9
C&L Inventory
Benzene, hexahydro-
Registration dossier
Cyclohexane
Registration dossier
Cyclohexane (8CI, 9CI)
Registration dossier
Cyclohexane HP 99,9
Registration dossier
Hexahydrobenzene
Registration dossier
Hexamethylene
Registration dossier
Hexanaphthene
Registration dossier
not applicable
Registration dossier
110-82-7
CAS number
EC Inventory, C&L Inventory, Restriction list, Registration dossier, REACH pre-registration, Other, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Occupational Exposure Limits - 2nd list - Indicative OELVs, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Food Contact Regenerated Cellulose Directive - Authorised Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
601-017-00-1
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 4 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Form
Liquid (100%) [1]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 3 studies submitted
  • 1 study processed
R Melting / freezing point
6.5 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
6.5 °C

Boiling point

Study results
  • 3 studies submitted
  • 1 study processed
R Boiling point
80.7 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
80.7 °C

Density

Study results
  • 4 studies submitted
  • 1 study processed
R Relative density
0.774 @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
773.9

Vapour pressure

Study results
  • 5 studies submitted
  • 1 study processed
R Vapour pressure
12.4 kPa @ 24 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
12.4 kPa @ 24 °C

Partition coefficient

Study results
  • 3 studies submitted
  • 1 study processed
R Log Pow
3.44 @ 25 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
3.44 @ 20 °C

Water solubility

Study results
  • 4 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
52 mg/L @ 23.5 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
52 mg/L @ 23.5 °C

Solubility in organic solvents / fat solubility

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 3 studies submitted
  • 1 study processed
R Flash point
-20 °C @ 101.35 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flash point at 101 325 Pa
-20 °C

Auto flammability

Study results
  • 2 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
260 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Autoflammability / self-ignition at 101 325 Pa
260 °C

Flammability

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
Extremely flammable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Highly flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 2 studies submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
0.894 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Dynamic viscosity at 20 °C
0.894 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 5 studies submitted
  • 2 studies processed
R Dissipation half life (DT50)
15.14 - 52 h [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Half life in air
52 h

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 7 studies submitted
  • 1 study processed
C Interpretation of results
Readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 5
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation Factor (BCF) - L/kg ww
167 L/kg ww

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 3 studies submitted
  • 1 study processed
R log Koc
2.99 dimensionless [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Koc at 20°C
770

Henrys law constant (H)

Study results
  • 2 studies submitted
  • 2 studies processed
R H - (pressure) m³/mol
14 900 - 15 198.75 Pa m³/mol @ 20 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Henry's law constant
14 900 Pa.m³.mol-1 @ 20 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 44.7 µg/L (2)
Intermittent releases (freshwater) 9 µg/L (2)
Marine water 4.47 µg/L (2)
Intermittent releases (marine water) 900 ng/L (2)
Sewage treatment plant (STP) 3.24 mg/L (2)
Sediment (freshwater) 3.6 mg/kg sediment dw (2)
Sediment (marine water) 360 µg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil 694 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 13 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 4.53 mg/L [1]
EL50 (72 h) 2.331 mg/L [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other 11
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EL10 (21 days) 447 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 9 studies submitted
  • 2 studies processed
P/RResults
EC50 (48 h) 900 - 2 400 µg/L [2]
EL50 (48 h) 4.36 mg/L [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other 1 5
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EL10 (21 days) 835 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 8 studies submitted
  • 2 studies processed
P/RResults
EC50 (72 h) 3.428 - 9.317 mg/L [3]
NOEC (72 h) 952 µg/L [2]
EL10 (72 h) 462 µg/L [1]
EL50 (72 h) 2.413 mg/L [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other 2 3
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
4.425 mg/L
EC10 or NOEC for freshwater algae
925 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 9 studies submitted
  • 2 studies processed
P/RResults
IC50 (15 h) 29 mg/L [1]
EC10 (72 h) 6.821 mg/L [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other 1 5
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for microorganisms
29 mg/L
EC10 or NOEC for microorganisms
6.821 mg/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EC10 (28 days) 11.695 mg/kg sediment dw [1]
EC50 (28 days) 61.049 mg/kg sediment dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 / LC50 for freshwater sediment
61.049 mg/kg sediment dw
EC10 / LC10 or NOEC for freshwater sediment
11.695 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Short-term EC50 / LC50
59.943 mg/kg soil dw
Long-term EC10 / LC10 / NOEC
11.483 mg/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EC10 (28 days) 6.458 mg/kg soil dw [1]
LC50 (28 days) 33.708 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EC10 (21 days) 19.057 - 29.517 mg/kg soil dw [2]
LC50 (14 days) 99.48 - 154.076 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 700 mg/m³ neurotoxicity
Acute /short term: (DNEL) 1 400 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 700 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 1 400 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2 016 mg/kg bw/day neurotoxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 206 mg/m³ neurotoxicity
Acute /short term: (DNEL) 412 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 206 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 412 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1 186 mg/kg bw/day neurotoxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: Low hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 59.4 mg/kg bw/day neurotoxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 5 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 2 studies submitted
  • 1 study processed
P/RResults
LD50 5 000 mg/kg bw (rat) [1]
M/CInterpretations of results
Practically nontoxic [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
inhalation
  • 4 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 h) 32.88 mg/L air (rat) [1]
LC50 (4 h) 5 540 ppm (rat) [1]
M/CInterpretations of results
Practically nontoxic [1]

inhalation
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
dermal
  • 1 study submitted
  • 1 study processed
P/RResults
LD50 2 000 mg/kg bw (rabbit) [1]
M/CInterpretations of results
Practically nontoxic [1]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed LD50 5 000 mg/kg bw
Inhalation route:
No adverse effect observed LC50 32.88 mg/L air
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Study data: eye
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
Adverse effect observed (irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: inhalation
  • 4 studies submitted
  • 2 studies processed
P/RResults
NOAEC (rat): 500 - 7 000 ppm [2]
NOAEC (mouse): 500 - 2 000 ppm [2]

Study data: inhalation
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Inhalation route - systemic effects:
Adverse effect observed NOAEC 6 880 mg/m³ (subchronic, mouse)

Genetic toxicity

Study results
Study data: in vitro
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: in vivo
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Toxicity - InVitro
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Effect on fertility
Inhalation route:
No adverse effect observed NOAEC 24 080 mg/m³ (subchronic, rat)
Effect on developmental toxicity
Inhalation route:
No adverse effect observed NOAEC 24 080 mg/m³ (subchronic, rat)

Neurotoxicity

Study results
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2 1
Supporting study 3
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant