Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
205-358-3
CAS no.:
139-33-3
Index number:
Molecular formula:
C10H16N2O8.2Na
SMILES:
InChI:
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
22
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the classification provided by companies to ECHA in REACH registrations this substance is harmful if inhaled and may cause damage to organs through prolonged or repeated exposure.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance causes serious eye irritation, is harmful if swallowed, causes skin irritation and may cause respiratory irritation.

Breakdown of all 2421 C&L notifications submitted to ECHA

Eye Irrit. 2 H319
Acute Tox. 4 H302
Skin Irrit. 2 H315
STOT SE 3 H335
Acute Tox. 4 H332
STOT RE 2 H373
Not Classified
Carc. 2 H351
Aquatic Chronic 3 H412
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://chesar.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 20 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: washing & cleaning products, coating products, adhesives and sealants, biocides (e.g. disinfectants, pest control products), polishes and waxes, fillers, putties, plasters, modelling clay and non-metal-surface treatment products.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids) and outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)).

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and industrial abrasion processing with high release rate (e.g. sanding operations or paint stripping by shot-blasting). Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)).

This substance can be found in products with material based on: stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material).

This substance is used in the following products: lubricants and greases.

This substance is used in the following areas: formulation of mixtures and/or re-packaging and health services. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, laboratory work, closed batch processing in synthesis or formulation and hand mixing with intimate contact only with personal protective equipment available.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, in the production of articles, as processing aid and of substances in closed systems with minimal release. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following products: cosmetics and personal care products, metal working fluids, perfumes and fragrances, laboratory chemicals, hydraulic fluids and lubricants and greases.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, transfer of substance into small containers, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, laboratory work, batch processing in synthesis or formulation with opportunity for exposure, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and hand mixing with intimate contact only with personal protective equipment available.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: lubricants and greases.

This substance is used in the following areas: formulation of mixtures and/or re-packaging and mining. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release, as processing aid and in the production of articles. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, laboratory work and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures and as an intermediate step in further manufacturing of another substance (use of intermediates).

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Abbott Diagnostics GmbH, Max Planck Ring 2 D-65205 Delkenheim Hessen Germany
  • Asahi Chemical Europe s.r.o., Lužná 716/2 16000 Praha 6 - Vokovice Praha Czech Republic
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • CONSEL INMOB, S.L., Av Diagonal 519 1º 1ª 08029 Barcelona Spain
  • DOW BENELUX B.V. - OR1, Postbus 48 4530 AA Terneuzen Netherlands
  • Globalquimia, S.L.U., Avenida Diagonal, 519, 1º 1ª 08029 Barcelona Spain Spain
  • Honeywell Specialty Chemicals Seelze GmbH, Wunstorfer Str. 40 30926 Seelze Deutschland Germany
  • knoell Germany – OR – A1, Konrad-Zuse-Ring 25 68163 Mannheim Germany
  • Koopman International B.V., Distelweg 88 1031 HH Amsterdam Netherlands
  • Merck KGaA, Frankfurter Strasse 250 64293 Darmstadt Germany
  • Merck S.L.U., Calle Maria de Molina 28006 Madrid Spain
  • Nouryon Functional Chemicals B.V., Velperweg 76 6824 BM Arnhem Netherlands
  • PANREAC QUIMICA, SLU, Garraf, 2 E-08211 Castellar del Vallés Barcelona Spain
  • PRODUCTOS CAPILARES L'OREAL S.A., Calle Lopez Bravo n°78 Poligono Industrial Villalonquéjar 09001 BURGOS Spain
  • PURITY CHEMICALS S.L., Av. Tren Expreso, Parcelas 82-84 34200 Venta de Baños Palencia Spain
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • SA DABEER, C/ Pasaje Arrahona 18 2º 08210 Barbera del Vallés Spain
  • SCL ITALIA S.P.A., Via Fabio Filzi 25/A 20124 Milan Italy
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • SIGMA-ALDRICH CHIMIE SARL, 80 Rue de Luzais BP 701 38297 Saint Quentin Fallavier France
  • Sigma-Aldrich Company Limited, The Old Brickyard, New Road SP8 4XT Gillingham United Kingdom

Substance names and other identifiers

Disodium dihydrogen ethylenediaminetetraacetate
EC Inventory
disodium dihydrogen ethylenediaminetetraacetate
REACH pre-registration
Edetate Sodium
Other
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:2)
Other
2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid
C&L Inventory
2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid; sodium
C&L Inventory
acetic acid, (ethylenedinitrilo)tetra-, disodium salt
C&L Inventory
Acido Etilendiaminotetraacético Sal Disódica 2-hidrato
C&L Inventory
Dinatriumhydogenethylendiaminacetat
C&L Inventory
disodium 2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate
C&L Inventory
Disodium 2-[carboxymethyl-[2-[carboxymethyl-(2-oxido-2-oxoethyl)amino]ethyl]amino]acetate
C&L Inventory, Registration dossier
disodium 2-[carboxymethyl-[2-[carboxymethyl-(2-oxido-2-oxoethyl)amino]ethyl]amino]acetate dihydrate
C&L Inventory
disodium dihydrogen 2,2',2'',2'''-(ethane-,1,2-diyldinitro)tetraacetate
C&L Inventory
Disodium dihydrogen 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate
C&L Inventory, Registration dossier
disodium dihydrogen ethylendiaminetetraacetate
C&L Inventory
Disodium dihydrogen ethylenediaminetetraacetate
C&L Inventory, Registration dossier
Disodium dihydrogen ethylenediaminetetraacetate
C&L Inventory, Registration dossier
DISODIUM EDTA
C&L Inventory
Disodium EDTA
Registration dossier
DISODIUM ETHYLENEDIAMINE TETRAACETATE
C&L Inventory
Disodium ethylenediaminetetraacetate, EDTA disodium salt, EDTA-Na2, Edathamil, Edetate disodium salt, Sequestrene Na2, Ethylenediaminetetraacetic acid disodium salt
Registration dossier
EDTA - 2Na
C&L Inventory
EDTA disodium salt
Registration dossier
EDTA, disodium salt
Registration dossier
EDTA-Disodium salt
Registration dossier
EDTA2Na
Registration dossier
Ethylenediamine-N,N,N',N'-tetraacetic acid disodium salt dihydrate
C&L Inventory
ETHYLENEDIAMINETETRAACETIC AC DI-SODIUM SALT
C&L Inventory
Ethylenediaminetetraacetic acid disodium salt
C&L Inventory
Ethylenediaminetetraacetic acid disodium salt dihydrate
Registration dossier
Ethylenediaminetetraacetic acid, disodium salt
C&L Inventory
Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, disodium salt
C&L Inventory
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl) -, disodium salt
C&L Inventory
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:2)
C&L Inventory
SEQUESTRENE NA2;SODIUM (DI) ETHYLENEDIAMINE TETRAACETATE DIHYDRATE;VERSENE NA, DIHYDRATE;VERSENE DISODIUM;WANKLYN'S EDTA;TITRAVER(R) HARDNESS REAGENT;TITRIPLEX III;TITRIPLEX(R) III;(ethylenedinitrilo)tetra-aceticacidisodiumsalt;cheladrate;chelaplexiii;chelatoniii;complexoniii;dinatriumethylendiamintetraacetat;disodium(ethylenedinitrilo)tetraacetate;disodium(ethylenedinitrilo)tetraaceticacid;disodiumdiacidethylenediaminetetraacetate;disodiumdihydrogen(ethylenedinitrilo)tetraacetate;disodiumedathamil;disodiumsaltofedta
C&L Inventory
tetraacetic acid disodium salt
C&L Inventory
Dabeersen Na2 FARMACIA
Registration dossier
DABEERSEN Na2 HQ
Registration dossier
Dabeersen Na2 TECNICO
Registration dossier
Dissolvine NA2
Registration dossier
Dissolvine NA2-P
Registration dossier
Dissolvine NA2-S
Registration dossier
EDTA-Disodium salt (EDTA-2NA)
Registration dossier
Trilon BD
Registration dossier
VERSENE* NA CHELATING AGENT
Registration dossier
VERSENE* NA2 CRYSTALS CHELATING AGENT
Registration dossier
104244-09-9
CAS number
Other
104244-09-9
Deleted CAS number
Other
1236140-51-4
CAS number
Other
1236140-51-4
Deleted CAS number
Other
139-33-3
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other
1892-64-4
CAS number
Other
1892-64-4
Deleted CAS number
Other
37341-71-2
CAS number
Other
37341-71-2
Deleted CAS number
Other
42615-28-1
CAS number
Other
42615-28-1
Deleted CAS number
Other
6381-92-6
CAS number
C&L Inventory
69772-70-9
CAS number
Other
69772-70-9
Deleted CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Crystalline (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 2 studies submitted
  • 1 study processed
R Melting / freezing point
252 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 1 study submitted
  • 1 study processed
R Density
1.77 g/cm³ @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.767

Vapour pressure

Study results
  • 3 studies submitted
  • 1 study processed
R Vapour pressure
0 Pa @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 25 °C

Partition coefficient

Study results
  • 2 studies submitted
  • 1 study processed
R Log Pow
-4.3 @ 25 °C and pH 4.5 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
-4.3 @ 25 °C

Water solubility

Study results
  • 3 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
108 g/L @ 20 °C and pH 5.3 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
108 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
400 °C

Flammability

Study results
  • 3 studies submitted
  • 1 study processed
C Interpretation of results
Non flammable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
-0.12 - 10.44 @ 20 °C [6]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 1 study processed
R Dissipation half life (DT50)
2.23 h [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
2.23 h
Degradation rate constant with OH radicals
14.861 cm³ molecule-1 d-1

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 30 studies submitted
  • 2 studies processed
C Interpretation of results
Inherently biodegradable, fulfilling specific criteria (100%) [2]

Type of Study provided
Studies with data
Key study 6
Supporting study 16 1
Weight of evidence 7
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Inherently biodegradable, fulfilling specific criteria (100%)
Type of water
Freshwater (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
1.8 L/kg ww

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 6 studies submitted
  • 3 studies processed
R Koc
0.004 - 312.7 dimensionless @ 22 - 25 °C [4]
R log Koc
-2.35 - 2.49 dimensionless @ 25 °C [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4 1 1
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
312.7

Henrys law constant (H)

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Study results
  • 2 studies submitted
  • 1 study processed
% Distribution in Media:
R Air 0 % [1]
R Water 100 % [1]
R Soil 0 % [1]
R Sediment 0 % [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 2.5 mg/L (1)
Intermittent releases (freshwater) -
Marine water 250 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 50 mg/L (1)
Sediment (freshwater) No exposure of sediment expected (1)
Sediment (marine water) No exposure of sediment expected (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 1.1 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 9 studies submitted
  • 9 studies processed
P/RResults
LC50 (4 days) 100 - 2 340 mg/L [9]
LC0 (4 days) 100 mg/L [1]
LC100 (4 days) 100 - 4 200 mg/L [6]
NOEC (4 days) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 7 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (35 days) 25.7 - 35.1 mg/L [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 3 studies processed
P/RResults
EC50 (48 h) 100 - 140 mg/L [3]
EC0 (48 h) 100 mg/L [1]
EC100 (48 h) 180 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (21 days) 25 mg/L [1]
LOEC (21 days) 50 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 4 studies submitted
  • 4 studies processed
P/RResults
EC50 (72 h) 60 - 1 000 mg/L [6]
NOEC (72 h) 48.4 - 100 mg/L [5]
LOEC (72 h) 100 mg/L [1]
EC10 (72 h) 100 - 307.63 mg/L [3]
EC90 (72 h) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 2 1
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for freshwater algae
48.4 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 5 studies submitted
  • 3 studies processed
P/RResults
EC50 (24 h) 2.4 mmol/L [1]
NOEC (3 h) 640 mg/L [1]
EC10 (30 min) 500 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for microorganisms
500 mg/L

Sediment toxicity

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 3 studies submitted
  • 3 studies processed
P/RResults
EC50 (14 days) 156.46 mg/kg soil dw [1]
LC50 (14 days) 129 - 156.46 mg/kg soil dw [3]

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 84 - 420 mg/kg soil dw [5]
NOEC (14 days) 58.4 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1 1
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.5 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 3 mg/m³ repeated dose toxicity
Local Effects
Long-term: (DNEL) 1.5 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 3 mg/m³ repeated dose toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: (DNEL) 600 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 1.2 mg/m³ repeated dose toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 25 mg/kg bw/day repeated dose toxicity
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence 8 1
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 2 studies submitted
  • 1 study processed
P/RResults
LD50 2 800 mg/kg bw (rat) [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 2 800 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 2 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 7 studies submitted
  • 3 studies processed
P/RResults
NOAEL (rat): 500 mg/kg bw/day [2]
NOAEL (mouse): 500 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1 1
Supporting study 2
Weight of evidence 2
Other 1
Data waiving
no waivers
Study data: inhalation
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOAEC (rat): 3 - 15 mg/m³ air [2]
LOAEC (rat): 15 - 30 mg/m³ air [2]

Study data: inhalation
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 500 mg/kg bw/day (chronic, rat)
Inhalation route - local effects:
Adverse effect observed NOAEC 3 mg/m³ (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 4 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 495 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study 3
Weight of evidence 1 1
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
Adverse effect observed NOAEL 250 mg/kg bw/day (chronic, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant